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Abstract

This study develops a sure joint feature screening method for the case–cohort design with ultrahigh-dimensional covariates. Our method is based on a sparsity-restricted Cox proportional hazards model. An iterative reweighted hard thresholding algorithm is proposed to approximate the sparsity-restricted, pseudo-partial likelihood estimator for joint screening. We rigorously show that our method possesses the sure screening property, with the probability of retaining all relevant covariates tending to 1 as the sample size goes to infinity. Our simulation results demonstrate that the proposed procedure has substantially improved screening performance over some existing feature screening methods for the case–cohort design, especially when some covariates are jointly correlated, but marginally uncorrelated, with the event time outcome. A real data illustration is provided using breast cancer data with high-dimensional genomic covariates. We have implemented the proposed method using MATLAB and made it available to readers through GitHub.

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Sure Joint Screening for High Dimensional Cox's Proportional Hazards Model Under the Case-Cohort Design

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