Infantile hydrocephalus (HCP) is a condition in which there is an abnormal buildup of cerebrospinal fluid in the ventricles within the first few months of life, which puts pressure on surrounding brain tissues. Compression of the developing brain increases the risk of secondary brain injury and cognitive disabilities.
Methods:
In this study, we used diffusion-weighted imaging and resting-state functional magnetic resonance imaging to investigate the effects of ventricle dilatation on structural and functional brain networks in children with shunted infantile HCP and examined how these brain changes may impact executive function.
Results:
We found that children with HCP have altered structural and functional connectivity between and within large-scale networks. Moreover, hyperconnectivity between the ventral attention and default mode network in children with HCP correlated with reduced executive function scores. Compared with typically developing age-matched control participants, our patient population also had lower fractional anisotropy in posterior white matter.
Discussion:
Overall, these findings suggest that infantile HCP has long-term effects on brain network connectivity, white matter development, and executive function in children at school age. Future work will examine the relationship between ventricular volumes before shunt placement in infancy and brain network development throughout childhood.
Impact statement
Infantile hydrocephalus (HCP) increases the risk of cognitive disability and secondary brain injury due to compression of the developing brain. In this study, we report that children with HCP show hyperconnectivity between the ventral attention and default mode network, which correlated with reduced executive function scores. HCP children also had lower fractional anisotropy in posterior white matter. This work highlights the long-term impact of infantile HCP on brain network connectivity and executive function in children at school age.
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