We describe future steps in the direct characterization of habitable exoplanets subsequent to medium and large mission projects currently underway and investigate the benefits of spectroscopic and direct imaging approaches. We show that, after third- and fourth-generation missions have been conducted over the course of the next 100 years, a significant amount of time will lapse before we will have the capability to observe directly the morphology of extrasolar organisms. Key Words: Far future missions—Direct imaging—High-resolution spectroscopy—Habitable exoplanets—Exo-moons—Surface features. Astrobiology 10, 121–126.
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