Drug Repurposing Patent Applications January–March 2021

Patel D , Teckman JH : Alpha-1-antitrypsin deficiency liver disease. Clin Liver Dis, 2018; 22:643–655.

Faverio P , Stainer A , De Giacomi F , et al.: Molecular pathways and respiratory involvement in lysosomal storage diseases. Int J Mol Sci, 2019; 20:327.

Oladimeji PO , Chen T : PXR: more than just a master xenobiotic receptor. Mol Pharmacol, 2018; 93:119–127.

Bahrami A , Bianconi V , Pirro M , Orafai HM , Sahebkar A : The role of TFEB in tumor cell autophagy: diagnostic and therapeutic opportunities. Life Sci, 2020; 244:117341.

Smith RP , Eckalbar WL , Morrissey KM , et al.: Genome-wide discovery of drug-dependent human liver regulatory elements. PLoS Genet, 2014; 10:e1004648.

Banerjee D , Sanyal S : Protein folding activity of the ribosome (PFAR)—a target for antiprion compounds. Viruses, 2014; 6:3907–3924.

Voisset C , Blondel M , Jones GW , et al.: The double life of the ribosome: when its protein folding activity supports prion propagation. Prion, 2017; 11:89–97.

Tribouillard-Tanvier D , Béringue V , Desban N , et al.: Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions. PLoS One, 2008; 3:e1981.

Oumata N , Nguyen PH , Beringue V , et al.: The toll-like receptor agonist imiquimod is active against prions. PLoS One, 2013; 8:e72112.

Blondel M , Soubigou F , Evrard J , et al.: Protein folding activity of the ribosome is involved in yeast Prion propagation. Sci Rep, 2016; 6:32117.

Bamia A , Sinane M , Nait-Saidi R , et al.: Anti-prion drugs targeting the protein folding activity of the ribosome reduce PABPN1 aggregation. Neurotherapeutics 2021. [Epub ahead of print]; DOI: 10.1007/s13311-020-00992-6.

Takimoto Y , Ishida Y , Nakamura Y , et al.: 5-HT(3) receptor expression in the mouse vestibular ganglion. Brain Res, 2014; 1557:74–82.

Vega Lde L , Muñoz E , Calzado MA , et al.: The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway. Biochem Pharmacol, 2005; 70:369–380.

Venail F , Biboulet R , Mondain M , Uziel A : A protective effect of 5-HT3 antagonist against vestibular deficit? Metoclopramide versus ondansetron at the early stage of vestibular neuritis: a pilot study. Eur Ann Otorhinolaryngol Head Neck Dis, 2012; 129:65–68.

Petremann M , Romanet C , Broussy A , Tran Van Ba C , Poli S , Dyhrfjeld-Johnsen J : SENS-401 effectively reduces severe acoustic trauma-induced hearing loss in male rats with twice daily administration delayed up to 96hours. Otol Neurotol, 2019; 40:254–263.

Ekinci E , Rohondia S , Khan R , Dou QP : Repurposing disulfiram as an anti-cancer agent: updated review on literature and patents. Recent Pat Anticancer Drug Discov, 2019; 14:113–132.

Bernier M , Harney D , Koay YC , et al.: Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome. NPJ Aging Mech Dis, 2020; 6:8.

Chen D , Dou QP : New uses for old copper-binding drugs: converting the pro-angiogenic copper to a specific cancer cell death inducer. Expert Opin Ther Targets, 2008; 12:739–748.

Reinhardt S , Stoye N , Luderer M , et al.: Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer's disease hallmarks. Sci Rep, 2018; 8:1329.

Libeu CA , Descamps O , Zhang Q , John V , Bredesen DE : Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain. PLoS One, 2012; 7:e40027.

Puzynski S , Rode A , Zaluska M : Studies on biogenic amine metabolizing enzymes (DBH, COMT, MAO) and pathogenesis of affective illness. I. Plasma dopamine-beta-hydroxylase activity in endogenous depression. Acta Psychiatr Scand, 1983; 67:89–95.

Ponsford M , Castle D , Tahir T , et al.: Clozapine is associated with secondary antibody deficiency. Br J Psychiatry, 2018; 214:1–7.

Ponsford MJ , Steven R , Bramhall K , et al.: Clinical and laboratory characteristics of clozapine-treated patients with schizophrenia referred to a national immunodeficiency clinic reveals a B-cell signature resembling common variable immunodeficiency (CVID). J Clin Pathol, 2020; 73:587–592.

Cocco M , Stephenson S , Care MA , et al.: In vitro generation of long-lived human plasma cells. J Immunol, 2012; 189:5773–5785.

Lamore SD , Cabello CM , Wondrak GT : The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in human skin cells. Cell Stress Chaperones, 2010; 15:309–322.

Hoang BX , Han B , Shaw DG , Nimni M : Zinc as a possible preventive and therapeutic agent in pancreatic, prostate, and breast cancer. Eur J Cancer Prev, 2016; 25:457–461.

Schwartz JR : Zinc pyrithione: a topical antimicrobial with complex pharmaceutics. J Drugs Dermatol, 2016; 15:140–144.

Rudolf E , Cervinka M : Zinc pyrithione induces cellular stress signaling and apoptosis in Hep-2 cervical tumor cells: the role of mitochondria and lysosomes. Biometals, 2010; 23:339–354.

Carraway RE , Dobner PR : Zinc pyrithione induces ERK- and PKC-dependent necrosis distinct from TPEN-induced apoptosis in prostate cancer cells. Biochim Biophys Acta, 2012; 1823:544–557.

Sheynin Y , Rosa-Neto P , Hess RF , Vaucher E : Cholinergic modulation of binocular vision. J Neurosci, 2020; 40:5208–5213.

Tailor VK , Schwarzkopf DS , Dahlmann-Noor AH : Neuroplasticity and amblyopia: vision at the balance point. Curr Opin Neurol, 2017; 30:74–83.

Brascamp JW , Klink PC , Levelt WJ : The ‘laws’ of binocular rivalry: 50years of Levelt's propositions. Vision Res, 2015; 109(Pt A):20–37.

Sheynin Y , Chamoun M , Baldwin AS , Rosa-Neto P , Hess RF , Vaucher E : Cholinergic potentiation alters perceptual eye dominance plasticity induced by a few hours of monocular patching in adults. Front Neurosci, 2019; 13:22.

Kadri H , Lambourne OA , Mehellou Y : Niclosamide, a drug with many (re)purposes. ChemMedChem, 2018; 13:1088–1091.

Chen W , Mook RA Jr ., Premont RT , Wang J : Niclosamide: beyond an antihelminthic drug. Cell Signal, 2018; 41:89–96.

Mammucari C , Milan G , Romanello V , et al.: FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab, 2007; 6:458–471.

Zhao J , Brault JJ , Schild A , et al.: FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab, 2007; 6:472–483.

Wu CS , Li YR , Chen JJ , et al.: Antihelminthic niclosamide modulates dendritic cells activation and function. Cell Immunol, 2014; 288:15–23.

Jafarzadeh A , Nemati M , Khorramdelazad H , Hassan ZM : Immunomodulatory properties of cimetidine: its therapeutic potentials for treatment of immune-related diseases. Int Immunopharmacol, 2019; 70:156–166.

Kubecova M , Kolostova K , Pinterova D , Kacprzak G , Bobek V : Cimetidine: an anticancer drug?. Eur J Pharm Sci, 2011; 42:439–444.

Fritz I , Wagner P , Olsson H : Improved survival in several cancers with use of H1-antihistamines desloratadine and loratadine. Transl Oncol, 2021; 14:101029.

Zhang XO , Pratt H , Weng Z : Investigating the potential roles of SINEs in the human genome . Annu Rev Genomics Hum Genet 2021. [Epub ahead of print]; DOI: 10.1146/annurev-genom-111620-100736.

Soares JL , Oliveira EM , Pontillo A : Variants in NLRP3 and NLRC4 inflammasome associate with susceptibility and severity of multiple sclerosis. Mult Scler Relat Disord, 2019; 29:26–34.

Poh L , Kang SW , Baik SH , et al.: Evidence that NLRC4 inflammasome mediates apoptotic and pyroptotic microglial death following ischemic stroke. Brain Behav Immun, 2019; 75:34–47.

Ngo TD , Partin AC , Nam Y : RNA specificity and autoregulation of DDX17, a modulator of microRNA biogenesis. Cell Rep, 2019; 29:4024–4035.e5.

Ambati J , Magagnoli J , Leung H , et al.: Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development. Nat Commun, 2020; 11:4737.

Ten Broek RW , Eijkelenboom A , van der Vleuten CJM , et al.: Comprehensive molecular and clinicopathological analysis of vascular malformations: a study of 319 cases. Genes Chromosomes Cancer, 2019; 58:541–550.

Hammer J , Seront E , Duez S , et al.: Sirolimus is efficacious in treatment for extensive and/or complex slow-flow vascular malformations: a monocentric prospective phase II study. Orphanet J Rare Dis, 2018; 13:191.

Okada S , Hara M , Kobayakawa K , Matsumoto Y , Nakashima Y : Astrocyte reactivity and astrogliosis after spinal cord injury. Neurosci Res, 2018; 126:39–43.

Meletis K , Barnabé-Heider F , Carlén M , et al.: Spinal cord injury reveals multilineage differentiation of ependymal cells. PLoS Biol, 2008; 6:e182.

Zhu Y , Tchkonia T , Fuhrmann-Stroissnigg H , et al.: Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors. Aging Cell, 2016; 15:428–435.

Chang J , Wang Y , Shao L , et al.: Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat Med, 2016; 22:78–83.