Hydroxyapatite–zirconia (HA–ZrO2) nanocomposite coatings were prepared on Ti–6Al–7Nb implant by electrophoretic deposition at constant voltage of 50 V. The influence of zirconia content on the phase transition, morphological evolution, wettability and in vitro cyto-compatibility, together with the bioactivity of the nanostructured coatings was examined. From the X-ray diffractometer patterns, a tangible increase and decrease in the peak intensity and width of the characteristic peaks were observed after subsequent sintering at 1000°C for 1 h under a constant flow of argon gas. The sintered HA and HA–ZrO2 composite coatings showed higher hydrophilicity than the bare substrate. From the in vitro bioassays, surface treatment of Ti67 implant by HA–ZrO2 nanocomposite coating increased the cell response as well as the apatite formability, in simulated body fluid within 5 days of incubation.
HuangY, YanY, PangX.Electrolytic deposition of fluorine-doped hydroxyapatite/ZrO2 films on titanium for biomedical applications. Ceram Int. 2013;39:245–253.
2.
BaradaranS, BasirunWJ, ZalnezhadE, Fabrication and deformation behaviour of multilayer Al2O3/Ti/TiO2 nanotube arrays. J Mech Behav Biomed Mater. 2013;20:272–282.
3.
LiuX, ChuPK, DingC.Surface modification of titanium, titanium alloys, and related materials for biomedical applications. Mater Sci Eng R. 2004;47:49–121.
4.
Fei YinZ, WuL, Gui YangH, Recent progress in biomedical applications of titanium dioxide. Phys Chem Chem Phys. 2013;15:4844–4858.
5.
MaedaH, KasugaT.Bioactive Ceramic Coatings, Advances in Metallic Biomaterials. Berlin: Springer-Verlag GmbH; 2015. p. 103–126
6.
SinghI, KayaC, ShafferMSP, Bioactive ceramic coatings containing carbon nanotubes on metallic substrates by electrophoretic deposition. J Mater Sci. 2006;41:8144–8151.
7.
ShiJZ, ChenCZ, YuHJ, Application of magnetron sputtering for producing bioactive ceramic coatings on implant materials. Bull Mater Sci. 2008;31:877–884.
8.
HsuH-C, WuS-C, YangC-H, ZrO2/hydroxyapatite coating on titanium by electrolytic deposition. J Mater Sci Mater Med. 2009;20:615–619.
9.
DorozhkinSV.Bioceramics of calcium orthophosphates. Biomaterials. 2010;31:1465–1485.
10.
HonarmandiP, HonarmandiP, ShokuhfarA, Milling media effects on synthesis, morphology and structural characteristics of single crystal hydroxyapatite nanoparticles. Adv Appl Ceram. 2010;109:117–122.
11.
MohseniE, ZalnezhadE, BushroaA.Comparative investigation on the adhesion of hydroxyapatite coating on Ti–6Al–4V implant: A review paper. Int J Adhes Adhes. 2014;48:238–257.
12.
BaradararanS, HamdiM, MetselaarIH.Biphasic calcium phosphate (BCP) macroporous scaffold with different ratios of HA/β-TCP by combination of gel casting and polymer sponge methods. Adv Appl Ceram. 2012;111:367–373.
13.
ManiconePF, IommettiPR, RaffaelliL.An overview of zirconia ceramics: Basic properties and clinical applications. J Dent. 2007;35:819–826.
14.
SalehiS, FathiM.Fabrication and characterization of sol–gel derived hydroxyapatite/zirconia composite nanopowders with various yttria contents. Ceram Int. 2010;36:1659–1667.
15.
Nasiri-TabriziB, FahamiA.Reaction mechanisms of synthesis and decomposition of fluorapatite–zirconia composite nanopowders. Ceram Int. 2013;39:5125–5136.
16.
WangJ, HuangC, WanQ, Characterization of fluoridated hydroxyapatite/zirconia nano-composite coating deposited by a modified electrocodeposition technique. Surf Coat Technol. 2010;204:2576–2582.
17.
YugeswaranS, YoganandC, KobayashiA, Mechanical properties, electrochemical corrosion and in-vitro bioactivity of yttria stabilized zirconia reinforced hydroxyapatite coatings prepared by gas tunnel type plasma spraying. J Mech Behav Biomed. 2012;9:22–33.
18.
BaradaranS, ZalnezhadE, BasirunWJ, Statistical optimization and fretting fatigue study of Zr/ZrO2 nanotubular array coating on Ti–6Al–4V. Surf Coat Technol. 2014;258:979–990.
19.
QiuD, WangA, YinY.Characterization and corrosion behavior of hydroxyapatite/zirconia composite coating on NiTi fabricated by electrochemical deposition. Appl Surf Sci. 2010;257:1774–1778.
20.
ChangE, ChangWJ, WangBC, Plasma spraying of zirconia-reinforced hydroxyapatite composite coatings on titanium: Part II Dissolution behaviour in simulated body fluid and bonding degradation. J Mater Sci Mater Med. 1997;8:201–211.
21.
XieYT, ZhengXB, HuangLP, In vitro cytocompatibility of plasma-sprayed dicalcium silicate/zirconia composite coatings. Ceram Int. 2013;39:4707–4711.
22.
Perez-PageM, GuzalowskiR, MucheDNF, Synthesis of porous yttria-stabilized zirconia microspheres by ultrasonic spray pyrolysis. Mater Lett. 2017;188:41–44.
23.
WangHW, LeiXL, WangL, Tribological properties of CVD diamond films against zirconia ceramic. Mater Sci Forum. 2013;770:130–135.
24.
KimHJ, JeongYH, ChoeHC, Hydroxyapatite formation on biomedical Ti–Ta–Zr alloys by magnetron sputtering and electrochemical deposition. Thin Solid Films. 2014;572:119–125.
25.
RafieeradAR, AshraMR, MahmoodianR, Surface characterization and corrosion behavior of calcium phosphate-base composite layer on titanium and its alloys via plasma electrolytic oxidation: a review paper. Mater Sci Eng C. 2015;57:397–413.
26.
IzquierdoJ, BolatG, CimpoesuN, Electrochemical characterization of pulsed layer deposited hydroxyapatite-zirconia layers on Ti-21Nb-15Ta-6Zr alloy for biomedical application. Appl Surf Sci. 2016;385:368–378.
27.
BesraL, LiuM.A review on fundamentals and applications of electrophoretic deposition (EPD). Prog Mater Sci. 2007;52:1–61.
28.
RadiceS, KernP, BürkiG, Electrophoretic deposition of zirconia-Bioglass®composite coatings for biomedical implants. J Biomed Mater Res A. 2007;82A:436–444.
29.
DrdlikD, SlamaM, HadrabaH, Hydroxyapatite/zirconia-microfibre composites with controlled microporosity and fracture properties prepared by electrophoretic deposition. Ceram Int. 2015;41:11202–11212.
30.
AnanthKP, SuganyaS, MangalarajD, Electrophoretic bilayer deposition of zirconia and reinforced bioglass system on Ti6Al4V for implant applications: An in vitro investigation. Mater Sci Eng C. 2013;33:4160–4166.
31.
KhaliliV, Khalil-AllafiJ, XiaW, Preparing hydroxyapatite-silicon composite suspensions with homogeneous distribution of multi-walled carbon nano-tubes for electrophoretic coating of NiTi bone implant and their effect on the surface morphology. Appl Surf Sci. 2016;366:158–165.
32.
Afshar-MohajerM, YaghoubiA, RameshS, Electrophoretic deposition of magnesium silicates on titanium implants: Ion migration and silicide interfaces. Appl Surf Sci. 2014;307:1–6.
33.
FarnoushH, Aghazadeh MohandesiJ, Haghshenas FatmehsariD.Effect of particle size on the electrophoretic deposition of hydroxyapatite coatings: a kinetic study based on a statistical analysis. Int J Appl Ceram Technol. 2013;10:87–96.
34.
SamanipourF, BayatiMR, Golestani-FardF, An innovative technique to simply fabricate ZrO2–HA–TiO2 nanostructured layers. Colloids Surf B. 2011;86:14–20.
35.
SandhyaraniM, RameshbabuN, VenkateswarluK, Fabrication, characterization and in-vitro evaluation of nanostructured zirconia/hydroxyapatite composite film on zirconium. Surf Coat Technol. 2014;238:58–67.
36.
Gonzalo-JuanI, FerrariB, ColomerMT, Colloidal processing and sintering of porous percolative Ni-YSZ layers. J Membr Sci. 2010;352:55–62.
37.
ZhitomirskyI, Gal-OrL.Electrophoretic deposition of hydroxyapatite. J Mater Sci Mater Med. 1997;8:213–219.
38.
Mondragón-CortezP, Vargas-GutiérrezG.Electrophoretic deposition of hydroxyapatite submicron particles at high voltages. Mater Lett. 2004;58:1336–1339.
39.
AlbayrakO, El-AtwaniO, AltintasS.Hydroxyapatite coating on titanium substrate by electrophoretic deposition method: effects of titanium dioxide inner layer on adhesion strength and hydroxyapatite decomposition. Surf Coat Technol. 2008;202:2482–2487.
40.
AlbayrakO, OncelC, TefekM, Effects of calcination on electrophoretic deposition of naturally derived and chemically synthesized hydroxyapatite. Rev Adv Mater Sci. 2007;15:10–15.
41.
KokuboT.Surface chemistry of bioactive glass-ceramics. J Non-Cryst Solids. 1990;120:138–151.
42.
UstundagCB, KayaF, KamitakaharaM, Production of tubular porous hydroxyapatite using electrophoretic deposition. J Ceram Soc JPN. 2012;120:569–573.
43.
ParenteP, Sanchez-HerenciaAJ, Mesa-GalanMJ, Functionalizing Ti-surfaces through the EPD of hydroxyapatite/NANOY2O3. J Phys Chem B. 2013;117:1600–1607.
44.
FahamiA, Nasiri-TabriziB, Ebrahimi-KahrizsangiR.Synthesis of calcium phosphate-based composite nanopowders by mechanochemical process and subsequent thermal treatment. Ceram Int. 2012;38:6729–6738.
DhalJ, BoseS, BandyopadhyayA.Influence of pentavalent dopant addition to polarization and bioactivity of hydroxyapatite. Mater Sci Eng C. 2013;33:3061–3068.
47.
ŁyczkowskaE, SzymczykP, DybałaB, Chemical polishing of scaffolds made of Ti–6Al–7Nb alloy by additive manufacturing. Arch Civ Mech Eng. 2014;14:586–594.
48.
KumarS, KumarS, TiwariS, Biofunctionalized nanostructured zirconia for biomedical application: a smart approach for oral cancer detection. Adv Sci. 2015;2:1–9.
49.
ShirdarMR, IzmanS, TaheriMM, Effect of post-treatment techniques on corrosion and wettability of hydroxyapatite-coated Co–Cr–Mo alloy. Arab J Sci Eng. 2015;40:1197–1203.
50.
JunkerR, DimakisA, ThoneickM, Effects of implant surface coatings and composition on bone integration: a systematic review. Clin Oral Implants Res. 2009;20:185–206.
51.
SchwarzF, FerrariD, HertenM, Effects of surface hydrophilicity and microtopography on early stages of soft and hard tissue integration at nonsubmerged titanium implants: an immunohistochemical study in dogs. J Periodontol. 2007;78:2171–2184.
52.
RuppF, GittensRA, ScheidelerL, A review on the wettability of dental implant surfaces I: theoretical and experimental aspects. Acta Biomater. 2014;10:2894–2906.
53.
LeeM-H, MinBK, SonJS, Influence of different post-plasma treatment storage conditions on the shear bond strength of veneering porcelain to zirconia. Materials. 2016;9:1–12.
54.
ErakovićS, JankovićA, VeljovićD, Corrosion stability and bioactivity in simulated body fluid of silver/hydroxyapatite and silver/hydroxyapatite/lignin coatings on titanium obtained by electrophoretic deposition. J Phys Chem B. 2013;117:1633–1643.
55.
BaradaranS, MoghaddamE, Nasiri-TabriziB, Characterization of nickel-doped biphasic calcium phosphate/graphene nanoplatelet composites for biomedical application. Mater Sci Eng C. 2015;49:656–668.
