Beckwith-Hall, B.M., Holmes, E., Lindon, J.C., Gounarides, J., Vickers, A., Shapiro, M., and Nicholson, J.K. (2002). NMR-based metabonomic studies on the biochemical effects of commonly used drug carrier vehicles in the rat. Chem Res Toxicol15, 1136—41.
2.
Bollard, M.E., Holmes, E., Lindon, J.C., Mitchell, S.C., Branstetter, D., Zhang, W., and Nicholson, J.K. (2001). Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution 1H-NMR spectroscopy of urine and pattern recognition. Anal Biochem295, 194—202.
3.
Espina, J.R., Shockcor, J.P., Herron, W.J., Car, B.D., Contel, N.R., Ciaccio, P.J., Lindon, J.C., Holmes, E., and Nicholson, J.K. (2001). Detection of in vivo biomarkers of phospholipidosis using NMR-based metabonomic approaches. Magn Reson Chem36, 559—65.
4.
Holmes, E., Bonner, F., and Nicholson, J.K. (1995). Comparative studies on the nephrotoxicity of 2-bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis). Arch Toxicol70, 89—95.
5.
Holmes, E., Nicholls, A.W., Lindon, J.C., Connor, S.C., Connelly, J.C., Haselden, J.N., Damment, S.J.P., Spraul, M., Neidig, P., and Nicholson, J.K. (2000). Chemometric models for toxicity classification based on NMR spectra of biofluids. Chem Res Toxicol13, 471—78.
6.
Lenz, E.M., Bright, J., Wilson, I.D., Morgan, S.R., and Nash, A.F. (2003). A 1H NMR-based metabonomic study of urine and plasma samples obtained from healthy human subjects. J Pharm Biomed Anal33, 1103—15.
7.
Mortishire-Smith, R.J., Skiles, G.L., Lawrence, J.W., Spence, S., Nicholls, A.W., Johnson, B.A., and Nicholson, J.K. (2004). Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of drug-induced toxicity. Chem Res Toxicol17, 165—73.
8.
Nicholls, A.Q., Mortishire-Smith, R.J., and Nicholson, J.K. (2003). NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats. Chem Res Toxicol16, 1395—404.
9.
Nicholson, J.K., Connelly, J., Lindon, J.C., and Holmes, E. (2002). Metabonomics: A platform for studying drug toxicity and gene function. Nature Rev Drug Disc1, 153—61.
10.
Nicholson, J.K., Lindon, J.C., and Holmes, E. (1999). Metabonomics: Understanding the metabolic responses of liver systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica29, 1181—9.
11.
Robertson, D.G., Reily, M.D., Albassam, M., and Dethloff, L.A. (2001). Metabonomic assessment of vasculitis in rats. Cardiovasc Tox1, 7—19.
12.
Robertson, D.G., Reily, M.D., Sigler, R.E., Wells, D.F., Paterson, D.A., and Braden, T.K. (2000). Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants. Toxicol Sci57, 326—37.
13.
Slim, R.M., Robertson, D.G., Albassam, M., Reily, M.D., Robosky, L., and Dethloff, L.A. (2002). Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats . Toxicol Appl Pharmacol183, 108—16.
