This article explores manifestations of demoralization, addresses the issue of demoralization in relation to depression, and proposes a theoretical definition and model of demoralization as part of a continuum of depressogenic responses. The proposed model links selected person-environment factors, such as negative life events and perceived stress, with deficit coping and selected cognitive-attributional, affective, and social responses. In addition, pertinent psychotherapeutic nursing interventions to assist clients in combating demoralization and implications for research are discussed. With an understanding of the manifestations of demoralization, nurses can better recognize it in their clients and implement interventions to prevent the development of serious depression.