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Abstract

OBJECTIVE: To determine the effects of repeated pepsin/hydrochloric acid (HCl) exposure on the eustachian tube (ET).

STUDY DESIGN AND SETTING: ET function was studied in 22 rats. Group I (control) rats received transtympanic phosphate buffered saline solution; groups II (0.5 mg/ml) and III (2.0 mg/ml) received transtympanic pepsin/HCl. Test solutions were applied on day 0 with ET function evaluated on days 1, 2, 3, and 7 after exposure. Each 7-day period represents 1 cycle; all groups underwent 4 cycles. ET function was evaluated using passive opening and closing pressure, and active clearance of positive and negative pressure tests.

RESULTS: Rats exposed to pepsin/HCl had elevated passive opening pressures and a decreased ability to clear positive and negative pressure. A temporal relationship exists.

CONCLUSION: The results suggest middle ear exposure to pepsin/HCl leads to ET dysfunction in rats, and that this dysfunction is enhanced with repeated exposures.

SIGNIFICANCE: Gastroesophageal reflux may induce ET dysfunction.

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References

Bluestone

Pathogenesis of otitis media: Role of eustachian tube. Pediatri Infect Dis J 1996;15:281–91.

Paradise

Otitis media during early life: How hazardous to development?

Pediatrics 1981;68:869–73.

Gates

Acute otitis media and otitis media with effusion. In: Cummings

Fredrickson

Harker

, editors. Otolaryngology head and neck surgery, 3rd ed. St Louis: Mosby; 1998. p. 461–77.

Paradise

Haggard

Lous

Developmental implications of early-life otitis media. Int J Pediatr Otorhino-laryngol 1995;32:S37–S44.

Roberts

Burchinal

Koch

Otitis media in early childhood and its relationship to later phonological development. J Speech Hear Disord 1988;53:424–32.

Contencin

Maurage

Ployet

Gastroesophageal reflux and ENT disorders in childhood. Int J Pediatr Otorhinolaryngol 1995;32:S135–44.

Halstead

Role of gastroesophageal reflux in pediatric upper airway disorders. Otolaryngol Head Neck Surg 1999;120:208–14.

Butehorn

Downs

Prazma

Acute gastroesophageal reflux and eustachian tube function [Abstract]. ARO 22 Midwinter Research meeting, St Petersburg, FL: Feb 13–18, 1999.

Ohrui

Yamaya

Suzuki

Mechanisms of gastric juice-induced hyperpermeability of the cultured tracheal epithelium. Chest 1997;111:454–9.

10.

Flisberg

Ingelstedt

Ortegren

Controlled “ear aspiration” of air: A “physiological” test of tubal function. Acta Otolaryngol Suppl (Stockh) 1963;S182:35–8.

11.

Ohashi

Nakai

Current concepts of mucociliary dysfunction in otitis media with effusion. Acta Otolaryngol Suppl (Stockh) 1991;S486:149–61.

12.

Cassidy

Geisinger

Kraus

Continuous versus intermittent acid exposure in production of esophagitis in feline model. Dig Dis Sci 1992;37:1206–11.

13.

Contencin

Narcy

Nasopharyngeal pH monitoring in infants and children with chronic rhinopharyngitis. Int J Pediatr Otorhinolaryngol 1991;22:249–56.

14.

Cohen

Deflation opening pressure of the eustachian tube. Am J Otol 1989;10:138–41.

15.

Takahashi

Honjo

Hayashi

Middle ear pressures of children with otitis media with effusion. Ann Otol Rhinol Laryngol 1991;100:469–71.

16.

Miller

Eustachian tubal function in normal and diseased ears. Arch Otolaryngol 1965;81:41–8.

17.

Mulder

Kuijpers

The mucosal lining of the eustachian tube of the rat. Acta Otolaryngol (Stockh) 1991;111:342–8.

18.

Kumazawa

Iwano

Ushiro

Eustachian tube function tests and their diagnostic potential in normal and diseased ears. Acta Otolaryngol (Stockh) 1993;S500:10–3.

19.

Hellström

Salén

Stenfors

Anatomy of rat middle ear. Acta Anat 1982;112:346–52.

Function of the Eustachian Tube After Weekly Exposure to Pepsin/Hydrochloric Acid

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