Polyunsaturated fatty acids (PUFA) were administered to 168 patients over a period of 6 months in an open-label uncontrolled study. In 129 patient available for study, 86% experienced reduction in severity, frequency and duration of migraine attacks, 22% became free of migraine and more than 90% had reduced nausea and vomiting. Self-medication changed to simple analgesics in the majority except in 14% of patients without improvement.
FerrariMDSaxenaPR.On serotonin and migraine: a clinical and pharmacological review.
Cephalalgia1993;
13:
151–65
2.
MoskowitzMANozalkiKKraigRP.Neocortical spreading depression provokes the expression of C-fos protein-like immunoreactivity within trigeminal nucleus caudalis via trigeminovascular mechanisms.
J Neurosci1993;
13:
1167–77
3.
CarrollJDHiltonBP.The effects of reserpine injection on methysergide treated control and migrainous subjects.
Headache1974;
14:
149–56
4.
ForthWHenschlerDRummelW.Allgemeine und spezielle Pharmakologie und Toxikologie,
Wien Zrich.
Bibliografisches Institut Mannheim,
1975:
159–63
5.
SoykaDDienerHCPfaffenrathVGerberWDZieglerA.
In:
Therapie und Prophylaxe der Migrne—Aktual sierte Empfehlungen der Deutschen Migrane-und Kopfschmerz-gesellschaft.
Mnchen,
Arcis-Verlag,
1994:
7–22
6.
AdamO.Linoleic acid intake and prostaglandin. Essential fatty acids and total parenteral nutrition.
Paris Eurotext,
GhisolfiJ,
John Libbey1990:
81–93
7.
AdamO.Ernährungsphysiologische Untersuchungen mit Formeldiäten—Der Stoffwechsel mehrfach ungesättigter Fettsäuren und die Prostaglandinbiosynthese beim Menschen.
Klin Wochenschr1985;
63:
731–9
8.
IversenLFoghKKragballeK.Effect of dihomogammalinolenic acid and its 15-lipoxygenase metabolite on eicosanoid metabolism by human mononuclear leukocytes in vitro: selective inhibition of the 5-lipoxygenase pathway.
Arch Dermatol Res1992;
284:
222–6
9.
Headache Classification Committee of the International Headache Society.Classification and diagnostic criteria for headache disorders, cranial neuralgias, and facial pain.
Cephalalgia8 Suppl1988:
1–93
10.
HammMMalzC.Schach dem Schmerz!München:
Humboldt Verlag,
1993