Nerve fibres containing noradrenaline, acetylcholinesterase, vasoactive intestinal polypeptide and substance P were demonstrated in the dura mater of guinea-pigs using histochemical and immunohistochemical methods. These fibres accompanied blood vessels of all size, indicating a vasomotor role. In addition, some nerve fibres were observed without any obvious relation to the blood vessels. The rich supply of nerve fibres to the various parts of the dura mater may possibly be of importance in the pathogenesis of some types of headache.
ClarkSL.Nerve endings in the choroid plexus of the fourth ventricle.J Comp Neurol1928;47:1–21.
2.
CooperERA.Nerves of the meninges and choroid plexuses. In: Ciba Foundation Symposium on the Cerebrospinal Fluid.1958:80–92.
3.
StöhrP.Ueber die Innervation des Plexus choroideus des Menschen.Z Gesamte Anat1922;63:562–607.
4.
TsukerM.Innervation of the choroid plexus.Arch Neurol Psychiat (Chicago)1947;58:474–83.
5.
EdvinssonLFahrenkrugJHankoJOwmanCSundlerFUddmanR.VIP (vasoactive intestinal polypeptide)-containing nerves of intracranial arteries in mammals.Cell Tissue Res1980;208:135–42.
6.
EdvinssonLMacKenzieET.Amine mechanisms in the cerebral circulation.Pharmacol Rev1977;28:275–348.
7.
UddmanR.EdvinssonLOwmanCSundlerFPerivascular substance P: occurrence and distribution in mammalian pial vessels.J Cerebral Blood Flow Metabol1981;1:227–32.
8.
BjörklundAFalckBOwmanC.Fluorescence microscopic and microspectrofluorometric techniques for the cellular localization and characterization of biogenic amines. InRallJEKopinIJ. edsMethods of investigative and diagnostic endocrinology, vol 1. The thyroid and biogenic amines.Amsterdam:North-Holland Publishing Co,1972:318–68.
9.
KoelleGE.Cytological distributions and physiological functions of cholinesterases. InKoelleGB. edCholinesterases and anticholinesterase agents. Handbuch der experimentellen Pharmacologie,Suppl. 15.Berlin-Göttingen-Heidelberg:Springer-Verlag,1963:187–298.
10.
StefaniniMDeMartinoCZamboniC.Fixation of ejaculated spermatozoa for electron microscopy.Nature1967;216:173–4.
11.
CostaMBuffaRFurnessJBSolciaE.Immunohistochemical localization of polypeptides in peripheral autonomic nerves using whole mount preparations.Histochemistry1980;65:157–65.
12.
CoonsAELeducEHConollyIM.Studies on antibody production. I. A method for the histochemical demonstration of specific antibody and its application to a study of the hyperimmune rabbit.J Exp Med1955;102:49–60.
13.
FahrenkrugJSchaffalitzky de MuckadellOBRadioimmunoassay of vasoactive intestinal polypeptide (VIP) in plasma.J Lab Clin Med1977;89:1379–88.
14.
FahrenkrugJSchaffalitzky de MuckadellOBDistribution of vasoactive intestinal polypeptide in the porcine central nervous system.J Neurochem1978;31:1445–51.
15.
SporrongBFalkmerSRobboySJAlumetsJHåkansonRLjungbergOSundlerF.Neurohormonal peptides in ovarian carcinoids. An immunohistochemical study of eighty-one primary carcinoids and of intra-ovarian metastases from six mid-gut carcinoids.Cancer1981;in press.
16.
AlumetsJAlmPFalkmerSHåkansonRLjungbergOMårtenssonHSundlerFTibblinS. Immunohistochemical evidence of peptide hormones in endocrine tumors of the rectum. Cancer 1981; in press.
17.
BrodinEAlumetsJHåkansonRLeanderSSundlerF.Immunoreactive substance P in chicken gut, distribution, ontogeny and possible functional significance.Cell Tissue Res1981;216:455–69.
18.
LazarusLHLinnoilaRIHernandezODiAugustineRP.A neuropeptide in mammalian tissue with physalaemin-like immunoreactivity.Nature1980;287:555–8.
19.
LehmannJFibigerHC.Acetylcholinesterase and the cholinergic neuron.Life Sci1979;25:1939–47.
20.
AmentaFSancesarioGFerranteFCavallottiC.Acetylcholinesterase-containing nerve fibres in the dura mater of guinea-pig, mouse, and rat.J Neural Transm1980;47:237–42.
21.
LundbergJÄnggårdAFahrenkrugJHökfeltTMuttV.Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: Functional significance of co-existing transmitters for vasodilatation and secretion.Proc Natl Acad Sci USA1979;77:1651–5.
22.
UddmanRSundlerF.Substance P containing nerve fibres in the nasal mucosa.1981;to be published.
23.
HökfeltTJ-OKellerthNilssonGPernowB.Substance P: localization in the central nervous system and in some primary sensory neurons.Science1975;190:889–90.
24.
OlgartLHökfeltTNilssonGPernowB.Localization of substance P-like immunoreactivity in nerves in the tooth pulp.Pain1977;4:153–9.
25.
CuelloACDelFiaccoMPaxinosG.The central and peripheral ends of the substance P-containing sensory neurones in the rat trigeminal system.Brain Res1978;152:499–509.
26.
GazeliusBOlgartL.Vasodilatation in the dental pulp produced by electrical stimulation of the inferior alveolar nerve in the cat.Acta Physiol Scand1980;108:181–6.
