The concept of novelty has acquired a large number of diverse referents over the past quarter-century as a result of new methods that permit measurement of a variety of biological and behavioral reactions to novel incentives in both humans and animals. As a result, the term has acquired varied meanings. This analysis of novelty makes four claims. First, the specific state of uncertainty that a novel event creates depends on its origin. Second, unexpected events that alter the immediate stimulus surround (called stimulus novelty) should be distinguished from those that are inconsistent with an agent's long term knowledge (called conceptual novelty). Third, the critical features that render an event novel can vary with the agent's intention to classify or to act on an object and the balance between these two frames changes with development. Finally, the state of uncertainty created when an agent must choose one response from two or more alternatives differs from the states provoked by stimulus and conceptual novelty.