Abstract
Problem
Nasal continuous positive airway pressure (CPAP) is standard treatment of obstructive sleep apnea disease. Previous studies demonstrated that CPAP could induce apneic response. We will investigate the role of temperature and humility in positive continuous pressure flow-induced apnea in this study.
Methods
Using functionally isolated laryngeal animal modal, 42 adult male Sprague-Dawley rats were used. Study 1, animals were challenged with long-time stimulation (1 min) to detect the possibility of adaptation. Study 2, Different condition airflow (25C dry-25C dry, 25C dry-25C wet, 25C dry-37C dry and 25C dry-37C wet) was delivered to find the role of temperature and humidification in the flow-induced apneic response of larynx. Apneic index was calculated by prolonged expiratory time/baseline expiratory time.
Results
Laryngeal dry room temperature air exposure could induce apneic response and this response is reproducible and could be eliminated by humidification. In contraction, this apneic response could not be inhibited by increasing temperature.
Conclusion
Laryngeal cold dry air stimulation triggered the apneic response which could be eliminated by humidification but not by heating of air. This result informed us using CPAP with humidified air could decrease the CPAP-induced apnea.
Significance
Using CPAP with humidified air could decrease the CPAP-induced apnea and increase the CPAP compliance.
Support
NTUH93S034 by Dr. Tan and NSC 93-2314-B-075-028 by Dr. Ho.
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