Abstract
Objective
Examine the hypothesis if genetic polymorphisms in FAS and FASL genes, alone or in combination, are associated with oral and oropharyngeal squamous-cell carcinoma.
Methods
Prospective study based on 225 pacients with oral and oropharyngeal squamous-cell carcinoma and 215 controls, analyzed with PCR-RFLP.
Results
We observed a statistically significantly increased risk of oral and oropharyngeal squamous-cell carcinoma associated with the FASL -844 CT genotype (p=0,031). An increased risk of oral and oropharyngeal squamous-cell carcinoma was also associated with the FASL −844 T allele (p=0,04). Gene-gene interactions of FAS and FASL polymorphisms increased the risk of oral and oropharyngeal squamous-cell carcinoma in a multiplicative manner (p=0,04).
Conclusions
The results suggest that the presence of the allele T of FASL and its combination with G allele potentially increase the risk of cancer development.
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