OBJECTIVE: Determine onset and survival of head and neck squamous cell carcinoma (HNSCC) after lymphoma.
STUDY DESIGN: Case-control.
METHODS: Cases of HNSCC occurring as a second primary malignancy after prior diagnosis of lymphoma were extracted from the Surveillance, Epidemiology and End Results database. Survivals were compared with age- and stage-matched control cases of HNSCC.
RESULTS: A total of 333 cases of HNSCC after lymphoma (53 Hodgkin's and 280 non-Hodgkin's lymphomas) were identified as occurring on average 70.7 months after lymphoma. Post-lymphoma HNSCC cases exhibited poorer mean (median) Kaplan-Meier overall survival of 57.0 months (29.0 months) vs 84.2 months (42.0 months) for controls (P = 0.008). However, after exclusion of lymphoma-related deaths, post-lymphoma HNSCC survival improved to 63.9 (86.3) months (P = 0.191). HNSCC occurring after Hodgkin's disease exhibited better mean survival (92.5 months) than extranodal non-Hodgkin's (43.5 months) and nodal non-Hodgkin's (50.7 months) disease (P = 0.049).
CONCLUSIONS: Patients with HNSCC with prior lymphoma, especially non-Hodgkin's lymphoma, exhibit poorer survival than first primary HNSCC cases.
Get full access to this article
View all access options for this article.
References
1.
BhatiaSRobinsonLLOberlinOBreast cancer and other second neoplasms after childhood Hodgkin's disease. N Engl J Med1996; 334:745–51.
2.
HancockSLHoppeRT.Long-term complications of treatment and causes of mortality after Hodgkin's disease. Semin Radiat Oncol1996; 6:225–42.
3.
TravisLBCurtisREGlimeliusBSecond cancers among long-term survivors of non-Hodgkin's lymphoma. J Natl Cancer Inst1993; 85:1932–7.
4.
HaddyTBAddeMAMcCallaJLate effects in long-term survivors of high-grade non-Hodgkin's lymphomas. J Clin Oncol1998; 6:2070–9.
5.
BrennanPCoatesMArmstrongBSecond primary neoplasms following non-Hodgkin's lymphoma in New South Wales Australia. Br J Cancer2000; 82:1344–7.
6.
DongCHermminkiK.Second primary neoplasms among 53 159 haematolymphoproliferative malignancy patients in Sweden, 1958–1996: a search for common mechanisms. Br J Cancer2001; 85:997–1005.
7.
AndreMMournierNLeleuXSecond cancers and late toxicities after treatment of aggressive non-Hodgkin's lymphoma with the ACVBP regimen: a GELA cohort study on 2837 patients. Blood2004; 103:1222–8.
8.
MudieNYSwerdlowAJHigginsCDRisk of second malignancy after non-Hodgkin's lymphoma: a British cohort study. J Clin Oncol2006; 24:1–6.
9.
TravisLBHillDADoresGMBreast cancer following radiotherapy and chemotherapy among young women with Hodgkin's disease. JAMA2003; 290:465–75.
10.
GilbertESStovallMGospodarowiczLung cancer after treatment for Hodgkin's disease: focus on radiation effects. Radiat Res2003; 159:161–73.
11.
KohESTranTHHeydarianMA comparison of mantle versus involved-field radiotherapy for Hodgkin's lymphoma: reduction in normal tissue dose and second cancer risk. Radiat Oncol2007; 2:1–11.
12.
FranklinJPluetschowAPausMSecond malignancy risk associated with treatment of Hodgkin's lymphoma: meta-analysis of the randomized trials. Ann Oncol2006; 17:1749–60.
13.
MoserECNoordijkEMvan LeeuwenFERisk of second cancer after treatment of aggressive non-Hodgkin's lymphoma; an EORTC cohort study. Hematol J2006; 91:1481–8.
14.
NicholsACBhattacharyyaN.Racial differences in stage and survival in head and neck squamous cell carcinoma. Laryngoscope2007; 117:770–5.
15.
BhattacharyyaNNayakVK.Survival outcomes for second primary head and neck cancer: a matched analysis. Otolaryngol Head Neck Surg2005; 132:63–8.
16.
LeviFMoeckliRRandimbisonLSkin cancer in survivors of childhood and adolescent cancer. Eur J Cancer2006; 42:656–9.
17.
FranchiAMassiDGalloDRadiation-induced cutaneous carcinoma of the head and neck: is there an early role for p53 mutations?Clin Exp Dermatol2006; 31:793–8.
18.
KaragasMRMcDonaldJAGreenbergERRisk of basal cell and squamous cell skin cancers after ionizing radiation therapy. For The Skin Cancer Prevention Study Group. J Natl Cancer Inst1996; 88:1848–53.
19.
PatelSGSeeACWilliamsonPARadiation induced sarcoma of the head and neck. Head Neck1999; 21:346–54.
