To evaluate in vitro the effect of coenzyme Q10 (CoQ10) on ischemia-induced hair cell death.
Study Design
Organotypic cochlear cultures of newborn rats were subjected to ischemia with and without CoQ10.
Results
Addition of CoQ10 has not prevented HC loss.
Conclusion
CoQ10 seems to protect against only certain modes of cell death.
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References
1.
KhanMGrossJHauptHA pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium. Otolaryngol Head Neck Surg2007; 136:72–77.
2.
MazurekBWinterEFuchsJSusceptibility of the hair cells of the newborn rat cochlea to hypoxia and ischemia. Hear Res2003; 182:2–8.
3.
ShaSHTaylorRForgeADifferential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear Res2001; 155:1–8.
4.
SatoK.Pharmacokinetics of coenzyme Q10 in recovery of acute sensorineural hearing loss due to hypoxia. Acta Otolaryngol Suppl1988; 458:95–102.
5.
HenkeWJungK.Ischemia decreases the content of the adenine nucleotide translocator in mitochondria of rat kidney. Biochim Biophys Acta1991; 1056:71–75.
