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Abstract

Objective

Respiratory scleroma (RS) is a progressive, chronic, granulomatous disease caused by Klebsiella rhinoscleromatis. There is only one report of RS association with HLA-DQ3. In this study, molecular association of HLA class II and RS was determined.

Study Design and Setting

Nine RS patients and 163 healthy controls were compared. DQA1, DQB1, and DRB1 loci were typed.

Results

Statistical analysis demonstrated association between DQB1^*0301 and susceptibility to RS (P_c = 0.004). Haplo-type analysis showed an association of DQA1^*03011-DQB1^*0301 (P = 1.21E-19) and DRB1^*0407-DQA1^*03011-DQB1^*0301 (P = 0.0002).

Conclusions

Results established that DQA1^*03011-DQB1^*0301 haplotype is a strong risk factor for development of RS.

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References

Ballenger

JJ.

Granulomas of the face, nose, oral cavity and neck. In: Ballenger

, editor. Diseases of the nose, throat, ear, head and neck. Philadelphia (PA): Lea & Febiger; 1991. p. 314–23. (Grade D).

Martín

Flores

Terán-Ortíz

LAJ

Estudio inmunogenético de una familia con escleroma. An Otorrinolaringol Mex 1993; 38:99–101. (Grade B).

Bignon

Fernández-Vinña

Arnaiz-Villena

Technical handbook of Twelfth International Histocompatibility Workshop. Paris: HLA et Medicine; 1996. (Grade D).

Kotb

Norrby-Teglund

McGeer

An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections. Nat Med 2002; 8:1398–404. (Grade B).

Dabil

Kaplan

Duffy

Association of the HLA-DR15/HLA-DQ6 haplotype with development of choroidal neovascular lesions in presumed ocular histoplasmosis syndrome. Hum Immunol 2003; 64:960–4. (Grade B).

Schubert

Hutcheson

Graff

HLA-DQB1∗03 in allergic fungal sinusitis and other chronic hypertrophic rhinosinusitis disorders. J Allergy Clin Immunol 2004; 114:1376–83. (Grade B).

Gilbert

Plebanski

Gupta

Association of malaria parasite population structure, HLA, and immunological antagonism. Science 1998; 279:1173–7. (Grade B).

Association of HLA-DQA1 ∗ 03011-DQB1 ∗ 0301 haplotype with the development of respiratory scleroma