Post—Tympanostomy Tube Otorrhea: A Meta-Analysis

Abstract

INTRODUCTION: Post—tympanostomy tube otorrhea is the most common complication of tympanostomy tube placement. The incidence of this problem varies from 3.4% to 74%. Trials that study post—tympanostomy tube otorrhea may involve valid randomization “by patient” or “by ear.” In an attempt to define “best practice,” we conduct a meta-analysis to quantify the benefit of using topical prophylactic antibiotic drops in the postoperative period. We then compare our findings with previous results found in the literature.

METHODS: We selected randomized studies for which antibiotic drops had been used for at least 48 hours after tympanostomy tube insertion. Nine studies, 3 “by ear” and 6 “by patient,” met our inclusion criteria. The odds ratio and 95% confidence intervals were calculated for each to conduct the meta-analysis.

RESULTS: Overall, prophylaxis appears to be effective at reducing the incidence of post—tympanostomy tube otorrhea. The odds ratios for all studies were less than 1.0. However, none of the 3 “by ear” studies and only 3 of the 6 “by patient” studies were statistically significant. The mean odds ratio was 52%, suggesting that prophylaxis may reduce the incidence of post—tympanostomy tube otorrhea by half.

CONCLUSION: This meta-analysis suggests that routine post—tympanostomy tube prophylaxis is beneficial, but this finding is dependent on selection criteria used.

EBM rating: A-1a