Editorial Commentary: Dilemma in Trial Design: Do Current Study Designs Adequately Evaluate Effectiveness Antibiotic in ABRS?

1 SAHP. Antimicrobial treatment guidelines for the acute bacterial rhinosinusitis. Otolaryngol Head Neck Surg 2004;130:S1–45.

2 Williams JW Jr Aguilar C Cornell J , Antibiotics for acute maxillary sinusitis. Cochrane Database Syst Rev 2003;2:CD000243. Also available at: http://www.cochrane.org/cochrane/revabstr/AB000243.htm. Accessed March 12, 2005.

679 Agency for Health Care Policy and Research. Diagnosis and treatment of acute bacterial rhinosinusitis: summary, evidence report/ technology assessment. No. 9. Rockville, MD: Agency for Health Care Policy and Research; 1999. (AHCPR publication no. 99-E015.) Accessed July 30, 2004, at http://www.ahrq.gov/clinic/epcsums/sinussum.htm.

4 Benninger MS Holzer S Lau J. Diagnosis and management of acute bacterial rhinosinusitis: summary of the Agency for Health Care Policy and Research Evidence Based Report. Otolaryngol Head Neck Surg 200;122:1–7.

5 Axelsson A Chidekel N Grebelius N , Treatment of acute maxillary sinusitis: a comparison of four different methods. Acta Otolaryngol 1970;70:71–6.

6 US Food and Drug Administration. Guidance for industry: acute bacterial sinusitis—developing antimicrobial drugs for treatment. 1999. Available at: http://www.fda.gov/ohrms/dockets/98fr/2565dft.pdf.