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Abstract

OBJECTIVE: The mechanisms involved in the muco-sal alterations of laryngopharyngeal reflux (LPR) have not been well established. Reports indicate a decrease in the salivary epidermal growth factor (EGF) of patients with reflux esophagitis, but there are no reports of its behavior in LPR. Our objective was to determine the salivary concentration of EGF in adults with LPR.

STUDY DESIGN AND SETTING: Salivary EGF concentration of 26 patients with LPR and 20 healthy controls was determined using a commercially available ELISA kit. Patients with LPR were graded according to endoscopic and laryngoscopic criteria.

RESULTS: Salivary EGF concentration was significantly lower in the LPR group when compared with controls (P = 0.002). No correlation between the severity of laryngeal findings or esophagitis and salivary EGF concentration could be determined.

CONCLUSIONS: The decreased salivary concentration of EGF in adults with LPR suggests that a deficiency in this polypeptide could be associated to the disease.

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References

Johanson

Epidemiology of esophageal and supraesophageal injuries. Am J Med 2000;108:99S–103S.

Cherry

Margulies

Contact ulcer of the larynx. Laryngoscope 1968;78:1937–40.

Koufman

The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): A clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope 1991;101(Suppl):1–78.

Sarosiek

Scheurich

Marcinkiewicz

. Enhancement of salivary esophagoprotection: Rationale for a physiological approach to gastroesophageal reflux disease. Am J Gastroenterol 1996;110:675–81.

Sarosiek

McCallum

Do salivary organic components play a protective role in health and disease of the esophageal mucosa?

Digestion 1995;56(Suppl 1):32–7.

Rourk

Namiot

Sarosiek

. Impairment of salivary epidermal growth factor secretory response to esophageal mechanical and chemical stimulation in patients with reflux esophagitis. Am J Gastroenterol 1994;89:237–44.

Starkey

Orth

Radioimmunoassay of human epidermal growth factor (urogastrone). J Clin Endocrinol Metab 1977;45:1144–53.

Eckley

Costa

Estudo da concentrao salivar do fator de crescimento epidérmico em indivduos com laringite crnica por refluxo laringofarngeo. Rev Bras ORL 2003;69:590–7.

Helm

Dodds

Hogan

Salivary response to esophageal acid in normal subjects and patients with reflux esophagitis. Gastroenterology 1987;93:1393–7.

10.

Sonnenberg

Steinkamp

Weise

. Salivary secretion in reflux esophagitis. Gastroenterology 1982;83:889–95.

11.

Olsen

Poulsen

Kirkegaard

. Role of submandibular saliva and epidermal growth factor in gastric cytoprotection. Gastroenterology 1984;87:103–8.

12.

Itoh

Joh

Imai

. Experimental and clinical studies on epidermal growth factor for gastric mucosal protection and healing of gastric ulcers. J Clin Gastroenterol 1988;10(Suppl. 1):S7–S12.

13.

Konturek

Bielanski

Konturek

. Distribution and release of epidermal growth factor in man. Gut 1989;30:1194–200.

14.

Marcinkiewicz

Han

Zbroach

. The potential role of the esophageal pre-epithelial barrier components in the maintenance of integrity of the esophageal mucosa in patients with endoscopically negative gastroesophageal reflux disease. Am J Gastroenterol 2000;95:1652–60.

15.

Korsten

Rosman

Fishbein

. Chronic xerostomia increases esophageal acid exposure and is associated with esophageal injury. Am J Med 1991;90:701–6.

16.

Ino

Ushiro

Ino

. Kinetics of epidermal growth factor in saliva. Acta Otolaryngol (Stockh) 1993;(Suppl 500): 126–30.

17.

Dumbrigue

Sandow

Nguyen

. Salivary epidermal growth factor levels decrease in patients receiving radiation therapy to the head and neck. Oral Surg Oral Med Oral Pathol 2000;89:710–16.

18.

Moazzez

Anggiansah

Bartlett

. Tooth wear, saliva and symptoms of GERD: Is there a relationship? Abstr Dig Dis Week 2002;W1164:A–816.

19.

Gray

Donneley

Kingsnorth

Role of salivary epidermal growth factor in the pathogenesis of Barrett's columnar lined oesophagus. Br J Surg 1991;78:1461–6.

20.

Okita

Karita

Nakanishi

. Role of epidermal growth factor in protection and repair of gastric mucosal injury. J Clin Gastroenterol 1991;13(Suppl. 1):S103–S108.

21.

Ronkainen

Aro

Storskrubb

Prevalence of esophagitis and endoscopy-negative reflux disease in a population. A report from the Kalixandra Study. Abstr Dig Dis Week 2002;S1357:A-269.

Salivary Epidermal Growth Factor Concentration in Adults with Reflux Laryngitis

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