Abstract
Agilent Automation Solutions (Formerly Velocity11)
Technical Note: Sub-Microliter Dispensing
How sub-microliter dispensing is achievable on the Bravo and VPrep automated liquid-handling platforms using high-performance disposable 10-μL pipette tips is described in this new technical note from Velocity11. Experiments demonstrate the precise, accurate, and consistent liquid-handling capabilities of the Bravo and VPrep liquid-handling platforms in conjunction with a 384-Channel ST Disposable Tip Head. The 384–channel head, combined with Velocity11's 10-μL disposable tips, are proven capable of precisely pipetting volumes as low as 0.30 μL.
Technical Note: Low-Volume Dispensing
A new technical note from Velocity11 describes the precise, accurate, and consistent liquid-handling capabilities of the Bravo and VPrep liquid-handling platforms in conjunction with a 384-Channel ST Disposable Tip Head. The 384-channel head, combined with Velocity11's 10-μL disposable tips, prove to be capable of precisely pipetting volumes as low as 0.30 μL.
Technical Note: Isolation of Total RNA
A new automated method for isolation of total RNA in a 96-well format is described in a new technical note. The Strategene Absolutely RNA Microprep Kit allows high-throughput isolation of total RNA from small samples of cultured cells. This simple method eliminates toxic phenol—chloroform extractions and time-consuming ethanol precipitations by selectively binding RNA from cell lysate on 96-well silica fiber matrix plates. The RNA isolation protocol, however, requires extensive manual processing including repetitive pipetting, washing, vacuum filtration, and centrifugation steps.
Using Agilent's VWorks Automation Control Software, a script was written for the Bravo Platform to aspirate, dispense, mix, and transfer sample from a source 96-well tissue culture plate to the binding and collection plates of the Absolutely RNA 96 kit; as well as to automate sample wash steps using a vacuum filtration unit accessory on the Bravo Platform.
More: www.chem.agilent.com/Library/technicaloverviews/Public/5990–3558EN.pdf
Direct Drive Robot
According to Velocity11, its new Direct Drive Robot uses configurable Z-travel technology to enable greater stacking of instruments and more functionality in a smaller footprint. It also offers high operational precision, reliability, and safety. One-person, one-touch teaching enables fast and easy configuration. In the teach mode and using the teaching jig, the robot can be freely moved to any location. Once in the desired position, press the button on the end effector and when the light blinks, the position is taught. There is no need to use a pendant to jog the arm into position.
More: www.velocity11.com
VWorks Automation Control Software
Featuring a host of new features, Velocity11's new generation VWorks Automation Control Software is a complete solution that integrates and controls scheduling for all levels of automation from stand-alone liquid handlers to large integrated systems. VWorks enables life science discovery enterprises to maximize throughput, create quality leads sooner, and lower support burden with a single robust and versatile automation platform.
More: www.velocity11.com
Air Science USA
Purair 20 Ductless Fume Hood
The Purair 20 Ductless Fume Hood is designed to provide operator protection when using hazardous substances. A face velocity at 100 fpm ensures containment of fumes and an alarm alerts users when airflow falls to unacceptable levels. All mechanisms in the head section of the Purair 20 are on the clean side of the filter to prevent contamination, and switches and electrical components are totally isolated from the dirty airflow. The work area has a removable spillage tray that can be easily cleaned, and optional integral lighting is available.
More: www.air-science.com
Astech
Syringe-Pro
According to Astech, its new Syringe-Pro is a fully automated solution for prefilled syringe sample preparation and testing, including, syringe content deposit, sample dissolution (including vortexing), dilution, dispensing, and sample storage, with a further option for injecting to analysis equipment. Developed as an extension to Astech's Tablet-Pro technology, the Syringe-Pro can significantly increase the throughput of in-line sample analysis. The efficient disposal of spent consumables and syringes minimizes operator hazards.
More: www.astechprojects.com
ARTEL
Liquid-Handling Talk (LHTalk)
This new interactive, information-rich Web site is dedicated to small-volume liquid handling, and features user-populated discussion forums on topics such as automated liquid handling, handheld pipetting, quality control, data management, and regulatory news. The site also hosts blogs by industry experts and a platform for peer-to-peer collaboration to foster best practices in laboratory liquid handling.
More: www.LHTalk.org
Asynt
DrySyn COOL Systems
Asynt's DrySyn COOL systems provide controlled cooling for chemistry at or below ambient without the need for jacketed reaction vessels or ice baths. The DrySyn Multi COOL takes up to three flasks from 25 to 100 mL and combined with a suitable chiller/circulator and a standard magnetic stirrer gives a low-cost, compact reaction station with accurate temperature control down to −30 °C.
More: www.asynt.com
ATS RheoSystems
Capillary Rheometer
ATS's new capillary rheometer system features a two-level software interface that offers standard test control functionality as well as scientific evaluation capabilities for a better understanding of data.
Also featured is extensional viscosity measurement by convergent flow, hyperbolic die, or precision melt strength system with optional extrudate profile measurement. In addition, high temperature uniformity is maintained across the entire sample.
More: www.atsrheosystems.com
Bibby Scientific
Jenway Performance pH Electrodes
With in-built Platinum Plus reference systems, these new electrodes reduce analysis time through rapid equilibration when compared with conventional pH electrodes with AgCl reference systems, and increase the reproducibility of results following exposure to extremes of pH and temperature. Two glass-bodied Performance pH electrodes join the Jenway combination electrode range: a 12-mm general purpose model and a 4.5-mm semimicro electrode with 90 mm reach for small-volume samples. Both performance electrodes are designed for laboratories demanding high levels of accuracy in their measurements of general solutions and biological samples containing Tris buffers.
More: www.bibby-scientific.com
Stuart SMP40 Automatic Melting Point Apparatus
Stuart's new SMP40 automatic melting point apparatus incorporates the latest digital video imaging technology to detect and accurately capture the melting point of up to three samples simultaneously.
The only unit to offer a color VGA screen to view the melt process in real time or retrospectively, the SMP40 also introduces a split-design concept for maximum footprint flexibility.
Around 200 results in the form of .avi video files of the melt process can be stored by the SMP40 for viewing on the unit's screen; USB ports enable transfer to a flash drive or PC via Microsoft ActivSync.
More: www.bibby-scientific.com
Biotage
ISOLUTE SLE+ and EVOLUTE
According to Biotage, its polymer-based cartridges and 96-well plates are designed for solid-phase extraction of acidic, basic, and neutral compounds, providing efficient removal of salts, proteins, and phospholipids with a methanol/water generic methodology.
EVOLUTE ABN can be applied to a wide range of compounds with a single method. The EVOLUTE CX is a mixed mode hydrophobic/ionexchanger, optimized to give increased selectivity of basic compounds. ISOLUTE SLE+ (supported liquid-extraction) plates and columns are designed for aqueous samples and mimic traditional liquid—liquid extraction. The ISOLUTE SLE+ and ISOLUTE HM-N use water-immiscible solvents such as MTBE, ethyl acetate, and DCM to achieve isolation of the desired analytes. Endogenous compounds that often interfere with mass spec detection are efficiently removed with this technique. The format is compatible with automated instruments for increased throughput and performance.
More: www.biotage.com
BioTek
Synergy Mx Monochromator—Based Multimode Microplate Reader
The top- and bottom-read fluorescence system of this new monochromator—based Synergy Mx Multimode Microplate Reader with ultra fine-tuned performance is fully monochromator based and equipped with a variable bandpass selection system for added flexibility. According to BioTek, the fluorescent system's premium quadruple grating architecture guarantees an exquisite level of spectral discrimination and smooth spectral scans. Automated Z-height adjustment of the top optical head accommodates different microplate heights with 100-μm resolution. Optimal sensitivity is also achieved especially for low-volume samples.
With Synergy Mx's modular format, the required detection modes can be selected for specific needs and upgraded at any time. Shaking and temperature control systems as well as Gen5 Data Analysis Software are standard on all Synergy Mx models. Options include a UV—visible cuvette port and dual-reagent dispenser.
More: www.biotek.com
EL406 1536-Well Microplate Washer Dispenser
According to BioTek, its new EL406 1536-well Microplate Washer Dispenser offers fast and efficient microplate washing and reagent dispensing in 1536-well microplates, along with 384-well and 96-well formats for increased versatility. By combining microplate washing and up to three reagent dispensers, separate instruments are not necessary for each assay wash and reagent dispense step. Additionally, accurate and precise reagent dispensing is available in both peristaltic and microprocessor-controlled syringe drive reagent—dispensing technologies.
More: www.biotek.com
BMG Labtech
PHERAstar FS Microplate Reader
The PHERAstar FS is based on the PHERAstar Plus HTS microplate reader, and incorporates Tandem Technology, which uses highly sensitive, filter-based detection in all modes, and an ultra-fast UV/Vis Spectrometer; on-board reagent injectors for precise kinetic measurements; advanced bottom reading for cell-based assays; and a dedicated UV laser for all TR-FRET based assays.
More: www.bmglabtech.com
Copley Controls
Servotube Module
Designed for linear drive actuation in pick and place gantry and general materials handling applications, the new Servotube direct drive tubular linear motor module is a cost-effective solution for high-speed, flexible applications, and it replaces the need for belt drive or ball screw systems. According to Copley, in typical configurations, the Servotube Module is 10 times faster than traditional ball screw systems, with higher reliability.
More: www.copleycontrols.com
Cresset BioMolecular Discovery
FieldStere
FieldStere is a new software product designed to enable medicinal chemists to enrich their shortlist of drug candidates with structurally diverse compounds that share the same desired biological activity (bioisosteres). FieldStere allows the fine-tuning of the resulting bioisosteres to enhance potency and specificity while removing undesirable ADME and physical properties.
The new FieldStere product builds on Cresset's Field technology, which describes chemical structures in terms of the surface properties of the whole molecule. According to Cresset, these determine, much more accurately than existing tools, how a compound will interact with other molecules.
More: www.cresset-bmd.com
CyBio
CyBi-Well Vario with Capillary Head
According to CyBio, the integration of a capillary-based pipetting system into the CyBi-Well vario platform expands its liquid-handling capabilities. The capillary head is an easily exchangeable pipetting head for working within the nanoliter range, and is fully compatible with the existing platform and can be refitted. The pipetting platform CyBi-Well vario thus offers nine pipetting heads for a wide volume range and different pipetting methods.
The capillary head allows the simultaneous and contact-free transfer of 96 or 384 components with volume ranges between 25 and 1000 nL into dry assay microplates. The direct use of substances from a compound library is made possible without additional dilution and without the danger of precipitation of samples. Even DMSO-sensitive cell-based assays can be performed. The capillary head handles microplates with 96, 384, and 1536 formats with high throughput (approx. 15,000 samples per hour).
More: www.cybio-ag.com
Eksigent
ExpressHT-Ultra HPLC System
The ExpressHT-Ultra HPLC system provides short cycle times and high throughput for LC/MS studies of pharmacokinetics and drug metabolism. This new system is the latest Eksigent's line of products for small molecule analysis. With cycle times as short as 60 s, the ExpressHT-Ultra can run six 96-well sample plates overnight.
Running at a maximum pressure of 10,000 psi, the system enables the use of small particle stationary phases to deliver narrow peaks to the mass spectrometer. Employing columns with diameters of 1 mm or smaller, the ExpressHT-Ultra uses up to 95% less solvent per analysis than traditional HPLC systems.
More: www.eksigent.com
FEI Company
Magellan XHR SEM
According to FEI, its new Magellan extreme high-resolution scanning electron microscope (XHR SEM) allows users to quickly see 3D surface images at many different angles and at resolutions below 1 nm (about the size of 10 hydrogen atoms, side by side). Plus, the Magellan XHR SEM images sample at very low beam energies, avoiding distortions otherwise caused by the beam penetrating into the material below.
More: www.fei.com
Fluidigm Europe
BioMark 96.96 Dynamic Array
The BioMark 96.96 Dynamic Array from Fluidigm Europe is a new integrated fluidic circuit (IFC) capable of performing 9216 simultaneous real-time PCR experiments running TaqMan assays in nanolitre quantities.
The 96.96 Dynamic Array, the heart of Fluidigm's BioMark Genetic Analysis System, provides the flexibility of a microwell plate and the density of a microarray in one easy-to-use consumable. IFCs meter, multiplex, and combine nanolitre volumes of fluids, with precise control and reproducibility, many thousands of times—in parallel—on a single chip. Using Fluidigm's 96.96 Dynamic Array, users can set up 9216 experiments with just 192 pipetting steps (as compared to more than 18,000 pipetting steps when conducting this magnitude of experiments on standard 384-microwell plates).
More: www.fluidigm.com
Fluidigm 12.765 Digital Array
According to Fluidigm, its new 12.765 Digital Array is a unique IFC that uses a network of integrated channels and valves to divide a mixture of sample and PCR reagents into 765 replicates. The chip is specially designed to quantify target sequences very accurately and to detect low-abundance targets that differ by only a base pair from the wild-type sequence. With conventional assays, these targets may be otherwise difficult to detect in the sample as a whole. Using a Fluidigm Digital Array, the sample is diluted, mixed with PCR reagents, and loaded into the chip for partitioning. This partitioning in effect lowers the background within any one partition by a factor equal to the total number of partitions. After amplification, the target sequences may be quantified by counting the number of positives in relation to the volume of sample loaded.
More: www.fluidigm.com
Fluidigm 48.48 Dynamic Array
The new Fluidigm 48.48 Dynamic Array provides a highly efficient solution for single cell gene expression quantification studies using off-the-shelf TaqMan PCR assays and reagents. According to Fluidigm, the key to this technological advance is the matrix of channels, chambers, and valves in Fluidigm's 48.48 Dynamic Array that do the work of assembling assays. Use of the product results in the same qPCR data quality and experiment flexibility that is currently received from a 384-well system, while increasing throughput 24X.
More: www.fluidigm.com
Fluxion Biosciences
IonFlux-HT and IonFlux-16 Automated Patch Clamp Systems
According to Fluxion, these new systems combine proprietary microfluidic technology with integrated electronics to automate the traditional patch clamp assay for ion channel research. Ideal applications include primary and secondary screening, lead optimization, and toxicology screening.
The IonFlux-HT system includes 64 amplifiers and delivers between 8000 and 10,000 assays per day at a cost of just 30 cents per data point using 384-well plates. The IonFlux-16 provides all the features of the HT system with 16 amplifiers, using a 96-well-plate format, and delivering 2000 data points per day.
Both the IonFlux-HT and IonFlux-16 systems use standard well-plate formats with integrated microfluidic channels for cell patching and compound addition. The systems use a familiar plate reader format for simplicity and integration with existing automated liquid handlers. The IonFlux technology automates cell manipulation, trapping, sealing, whole-cell formation, and precise voltage protocols. Voltage clamping occurs continuously during all fluidic operations. Automated compound addition during the voltage protocol provides delivery to the cells in 50 ms, making the system ideal for ligand-gated channels.
More: www.fluxionbio.com
Fortress Interlocks
eGard Ssafety Interlocks
The eGard range of industrial safety interlocks now includes two new modules. For programmable logic controller (PLC) units that operate sinking current, the new BD and BE modules interface with the sourcing PLC input cards and operate with all standard eGard core modules. The BD module has the capability to handle two I/O and the BE modules can handle eight I/O; both are TUV approved.
eGard is a fully modular system that can control access to hazardous machinery via gate switch and trapped key technology and can also include simple machine or access controls such as push buttons, e-stops, and lamps. eGard can connect to PLCs and mimic panels, or can be used on an AS-interface network.
G.E. Healthcare
illustra triplePrep
This new kit is for rapid, simultaneous isolation of genomic DNA, RNA, and total denatured protein from a single undivided sample in less than 1 h. It is a combination of two spin columns and six optimized buffers for use with mammalian cell culture or animal tissue. High quality and yield DNA, RNA, and protein can be successfully isolated from a range of tissue types such as liver, kidney, spleen, brain, lung, and intestine and the cell lines HeLa, NIH-3T3, CHO-K1, and HEK-293. Tissue amounts ranging from 1 to 20 mg and cells amounts ranging from 0.3 to 5 million cells can be used for each preparation.
2-D Protein Extraction Buer
According to G.E., this new series of six buffers is for efficient and reproducible extraction of high-quality protein lysates with high yield. Resulting protein lysates are suitable for applications such as 2-D gel analysis and 1-D electrophoresis, or for rehydrating IPG strips before 2-D electrophoresis. The six new buffers (2-D Protein Extraction Buffer-I to -VI) are modifications of well-studied protein solubilizers, and are available as a dry powder, which is rehydrated with the provided diluent. The dry powder formulation eliminates problems associated with carbamylation, which can occur in solutions containing urea and may alter protein charge, producing spot artifacts on 2-D spot maps.
A 2-D Protein Extraction Buffer Trial Kit is available for evaluation of each extraction buffer, enabling optimization of total protein extraction. Each package contains the reagents necessary to prepare 50-mL buffer, and the 2-D Protein Extraction Buffer Trial Kit includes reagents for preparing 10 mL of each of the six buffers.
Mammalian Protein Extraction Buffer and Yeast Protein Extraction Buffer Kit
For efficient high-quality extraction of soluble protein from mammalian cultured cells and yeast cell, respectively, G.E. Healthcare now offers Mammalian Protein Extraction Buffer and Yeast Protein Extraction Buffer Kit. According to the company, these are mild, nondenaturing buffer compositions that deliver high-quality protein lysate compatible with most downstream applications without the need for mechanical cell lysis. Both products give highly reproducible, consistent results with maintained biological activity and address the need for simple and versatile sample preparation methods for protein extraction.
Genevac
Genevac Rocket
New low temperature, low pressure steam heating technology enables the Genevac Rocket Evaporator to simultaneously dry or concentrate as many as six large volume flasks five times faster than conventional rotary evaporators, the Genevac Rocket Evaporator is a powerful new tool for accelerating the safe production of chiral separation samples.
More: www.genevac.com
SampleGuard Temperature Control for HT-Series Evaporator Systems
SampleGuard temperature control is now available as an option on Genevac HT-Series evaporator systems to protect samples from overheating when evaporation is complete. The technique eliminates the possibility of thermal degradation. Comprising two thermocouples and a unique sample temperature radio transmitter, SampleGuard provides real-time feedback for accurate control of actual sample temperatures. SampleGuard probes can measure temperature at any point in the sample holder. One or two probes can be used to determine end of run. Unlike some thermocouple-based systems, it is not necessary to place a probe into a sample to be able to end the run automatically. Software in the HT systems detects the flow of energy through the sample holders and can detect the onset of dryness, stopping the process automatically, and preventing overprocessing of samples.
More: www.genevac.com
EZ-2 Personal Evaporator with Inert Gas Purge Module
To meet the requirements of the ATEX directives relating to safe removal of highly inflammable solvent vapors, the EZ-2 now can safely remove most organic solvents without forming an explosive mixture of organic vapor and air. The Inert Gas Purge option purges the air from the evaporator using an inert gas before commencing the evaporation process. The inert gas purge unit includes a key switch to lock the system thereby forcing all users to use the facility.
The inert gas purge option also can be useful where an inert atmosphere is required to help protect dry samples from moisture and/or oxygen exposure at the end of the evaporation process. The inert gas purge module controls gases entering the evaporator; therefore, at the end of the evaporation process, instead of releasing the vacuum by letting air into the chamber, inert gas is introduced instead. The inert gas atmosphere is then maintained until the user opens the system to claim dry samples.
More: www.genevac.com
GVK Biosciences and CRELUX
Fragment-Based Drug Discovery Platform
According to GVK Biosciences (GVK BIO) and CRELUX, the two companies have set up a highly robust fragment-based drug discovery platform proven to deliver rapidly, viable lead molecules. CRELUX's high-performance structural biology technologies together with GVK BIO's mature computer-assisted drug design (CADD) tools and other components of its drug discovery and development engine, encompass all steps from challenging targets to novel drug candidates.
CRELUX and GVK BIO provide seamless integration of all aspects of structure-based drug design and furnish accelerated timelines for moving molecules from concept into the clinic at an optimal cost. According to the companies, fragment-based drug design helps in visualizing binding modes and hence rationalize an accelerated SAR, allowing efficient lead optimization through CADD. CRELUX leverages its capabilities of all aspects of multifaceted structural studies toward X-ray elucidation of fragment or lead target complexes, whereas GVK BIO performs all discovery chemistry and biology work including in silico, in vitro, and in vivo studies as well as activities necessary to ensure preclinical candidate nomination.
More: www.gvkbio.com or www.crelux.com
Hamilton Company
BioLevitator Integrated Benchtop Cell-Culture System
According to Hamilton, its new BioLevitator was developed in collaboration with Global Cell Solutions and is the first benchtop 3-D cell-culture system on the market, delivering significant productivity gains to researchers in drug discovery and development, therapeutics, and regenerative medicine. The BioLevitator brings the engineering and automation expertise of Hamilton together with Global Cell Solutions' unique approach to cell culture for a scalable and automated system that reduces costs while improving the consistency and relevance of cultured cells.
The BioLevitator eliminates traditional peripheral cell-culture instruments, such as incubators and centrifuges, and minimizes manual handling. Each of the BioLevitator's four hydrophobic, PTFE-filtered 50-mL cell-culture tubes can produce cell growth equivalent to up to 10 T75 flasks, depending on the cell line. The system features a user-friendly touch-screen interface with real-time monitoring and control of environmental temperature and CO2 levels.
The BioLevitator uses the Global Eukaryotic Microcarrier (GEM) technology from Global Cell Solutions. The GEM provides an optically clear and nonautofluorescent pipettable substrate for adherent cell lines. The GEMs contain silica-coated iron particles that facilitate suspension of the cells without impellers. The particles' magnetic properties also enable the pelleting of cells for media changes. Custom protein coatings, including basement membrane, are available to facilitate growth of difficult cell lines and the GEM's alginate core inhibits ice crystals during cryopreservation, ensuring high survivability and cell function.
More: www.hamiltoncompany.com
Visiferm DO
According to Hamilton, this unique optical dissolved oxygen sensor significantly reduces measurement time with improved ease of use over classical Clark Cell technology, and is now available in North America. Symmetrical, heat-resistant, dual-channel optics and measurement amplifier are all self-contained in a standard 12-mm format. Polarization time that takes up to 8 h with traditional sensors is completed in as little as 15 min with the Visiferm. The sensor provides instant measurement with three connection options, including 4–20 mA current, ModBus RTU interface, or to traditional electrochemical transmitters and analyzers.
More: www.hamiltoncompany.com
Heidolph Brinkann
Carousel 12 Plus Reaction Station
The new Carousel 12 Plus Reaction Station not only heats up faster, but also uses more than one-third less energy to reach the same temperatures as its popular predecessor. The Carousel 12 Plus is designed to provide busy chemistry laboratories with an easy-to-use chemistry productivity tool that simultaneously heat or cools, stirs and reflux's up to 12 samples (1–20 mL) under an inert atmosphere. A host of new and improved features make it more flexible, easier to use, easier to clean, more resistant to chemical corrosion, and it provides enhanced reaction tube visibility.
IDBS and PerkinElmer
HCS Data Analysis Collaboration
A collaboration to improve data analysis and interpretation of high-content screening (HCS) features the integration of PerkinElmer's Columbus image data management system for HCS with IDBS's ActivityBase XE screening data management software. The collaboration provides a unified interface to access both Columbus's image data storage capabilities and ActivityBase XE's screening data analysis and interpretation features.
More: www.idbs.com or www.perkinelmer.com
Innovatis
Cedex XS Cell Analyzer
The Cedex XS is a semiautomated, image-based cell analyzer capable of delivering cell concentration, viability using the Trypan blue exclusion method, cell morphology, cell aggregation, and growth data from sample volumes as small as 10 μL. Users can reliably obtain accurate measurement data assisted by the use of Cedex Smart Slides; 8-well slides that enable multiple measurements in a single analysis that can be compared and averaged with the included software. The system software enables users to compare, review, store, publish, and share cell data with colleagues for collaborative studies, and has the ability store up to 5000 measurements. Cedex XS software is based on Cedex 2 Software.
More: www.innovatis.com
INTEGRA Biosciences
Applications Reports: Automated Dispensing of a Wide Range of Liquids
A new application report shows how a microbiological quality control group within a major pharmaceutical company uses the DOSE IT peristaltic pump to establish standard operating procedures based on automated protocols that precisely dispense various solutions like growth media and buffers into tubes, bottles, and Erlenmayer flasks.
A second companion application report discusses how a leading Swiss center for infectious diseases is using a combination of MEDIAJET Petri dish filler and DOSE IT peristaltic pump to minimize processing time, reducing thermal and mechanical stress to erythrocytes, and enabling production of top quality blood agar.
More: www.dose-it.info
Jeio Tech
Lab Companion Magnetic Stirrers
This new line of Lab Companion Magnetic Stirrers comes in 4 colors and offers 3 sizes—120, 170, and 220 mm with stirring capacities of 2, 4, and 5 L, respectively. Stirring speed range is from 150 to 2500 rpm.
Tops are polypropylene and come complete with two nonslip silicon covers to prevent sliding of sample vessels.
More: www.jeiotech.com
LabVantage
SAPPHIRE LIMS
The SAPPHIRE Laboratory Information Management Suite now operates on the JBoss, BEA WebLogic, and IBM WebSphere Application Servers, in addition to the originally supported Sybase EA Server. According to LabVantage, SAPPHIRE now runs on most of the leading Java EE (formerly J2EE) compliant application server platforms available in the market.
More: www.labvantage.com
Malvern Instruments
Application Note: Viscotek Detector for GPC/SEC
According to Malvern, a new photodiode array detector for the TDAmax size exclusion chromatography (SEC) system from Viscotek provides a powerful and flexible tool for the rapid analysis of a wide range of proteins and biopolymers. These include identifying protein conjugates and complexes, aggregation and stability, and determining concentration ratios. SEC, also known as gel permeation chromatography (GPC), has further applications in examining loading efficiencies for drug delivery platforms, correlating these with molecular weight or size.
Zetasizer Auto Plate Sampler
According to Malvern, its new Zetasizer Auto Plate Sampler (APS) is designed for protein specialists, and delivers fully automated protein and nanoparticle size measurements using dynamic light scattering for improved productivity. Unlike other systems, the Zetasizer APS does not require microwell plates to be flat bottomed or have specific optical properties. A unique sample handling process makes it compatible with virtually all commercially available microwell plates. Automated measurement procedures using industry standard 96- or 384-well plates enable users to simply insert a sample plate and press start.
More: www.malvern.com
Mettler Toledo
LabX Balance v1.5
LabX balance software continues to improve efficiency and productivity in the laboratory and promotes a high level of regulatory compliance through full support of the good weighing practice guidelines. It offers full user guidance on a touch-screen display or PC, and now includes more than 25 built-in job templates. Creation of customized templates for standard operating procedures is now easier with functions available for weighing, data acquisition, and data storage.
LabX balance v1.5 is now fully compatible with Windows Vista and activation of the software via the Internet has been made easier. LabX connect balance v1.5 also offers improvements for integration of third-party tools with the updated System Integration Guide that provides programming examples of important functions in three programming languages.
More: www.mt.com/LabX
Ergonomic Pipette Calibration
An integrated 100-mL evaporation trap is now available for use with XP and XS balance ranges. Using the same trap design as Mettler Toledo's dedicated pipette calibration systems, this accessory allows rapid switching between analytical weighing and pipette calibration functions. According to Mettler Toledo, the new 100-mL evaporation trap exceeds ISO 8655 pipette calibration recommendations and its high capacity is unique to the market, offering unrivaled calibration performance for pipette volumes from 10 μL up to 10 mL. Both trap geometry and pipetting container design are optimized to achieve minimal evaporation and high reproducibility.
More: www.mt.com
Rainin E-Man Hybrid
The new ergonomic E-Man Hybrid pipette incorporates the operational simplicity of a manual pipette with real-time sensing technology, allowing real-time monitoring of the position of the piston and the amount of liquid dispensed. According to Mettler Toledo, with continuous volume tracking in place, this pipette offers great value for titration and partial dispensing, as well as for measuring aspirated fluids. Built-in GMP/GLP functions include saved calibration and service alerts. A visual alert indicates inadequately executed pipetting cycles. Of course, this also aids users in practicing a perfect pipetting technique.
Rainin Pos-D
According to Mettler Toledo, its Rainin Pos-D is the world's first positive displacement pipette with ergonomic features. Nonaqueous solutions—namely those that are viscous, dense, or high in vapor pressure—are difficult to aspirate correctly when using regular air-displacement pipettes. The Rainin Pos-D pipette overcomes this challenge by ensuring that the necessary pressure equalization to handle such solutions exists within the pipette tip.
IND226x Weighing Terminal
According to Mettler Toledo, its new IND226x weighing terminal is able to withstand the toughest operating and cleaning conditions in chemical and pharmaceutical facilities because of its IP66-protected stainless steel housing. Organization Internationale de Métrologie Légale, National Type Evaluation Program metrological approvals, and international Ex certifications each allow for global use of the terminal in the hazardous area of zone 1/21.
More: www.mt.com/filling
Micronic Europe
Deluxe Starter Pack
The Micronic Deluxe Starter Pack contains everything needed to start using 2D-coded sample storage tubes enabling laboratory workers to ensure a secure sample logistics system and eliminate the costly possibility of false sample identities. With a unique inside ring, Micronic storage tubes are designed for secure sealing and maximum sample volume storage. Used with the Electric Capper, supplied as part of the Deluxe Starter Pack, TPE caps are pushed into exactly the right depth of each Micronic tube to ensure a reliable, high integrity seal.
More: www.micronic.com
Oxford Expression Technologies
baculoXPRESS
baculoXPRESS is a new suite of comprehensive baculovirus expression services that can be tailored to individual requirements. Lead by Professors Linda King and Robert Possee, the new services provide customers with multiple recombinant viruses simultaneously, quickly, and cost-effectively. The routine use of flashBACGOLD/ULTRA in the services results in increased protein yield and quality.
baculoXPRESS services include gene synthesis; PCR cloning; subcloning; production of recombinant viruses using flashBAC, flashBACGOLD, or flashBACULTRA virus DNA; expression optimization; protein production and purification; and next-day virus titration using OET's baculoQUANT methodology—each providing defined deliverables with relevant documentation. Additional expression services are available on request.
More: www.oetltd.com
Oerlikon Leybold Vacuum
SOGEVAC BI Pump Series
According to Oerlikon, its new single-stage oil-sealed rotary vacuum pump is designed for demanding analytical applications that require low-noise operation and compact design, and is considered an ideal match for mass spectrometry equipment. The SOGEVAC SV16 BI can be easily integrated into a range of analytical instruments. External exhaust filtration and oil return is not needed, due to the SOGEVAC SV16 BI's internal exhaust filter and oil recovery system. In addition, it can operate at all pressures continuously without any add-on accessories.
Oxford Gene Technology
Genomic DNA Labeling Kit for Cytogenetics Arrays
According to Oxford Gene Technology (OGT), its new Genomic DNA Labeling Kit offers a fast and simple protocol, and is fully optimized for OGT's CytoSure family of high-resolution oligonucleotide arrays. The kit contains Cy3 and Cy5 dyes for dual-color hybridizations, and uses a unique buffer formulation to allow more efficient use of reagents without loss of signal intensity. The kit contains everything required for the protocol, including nucleotide mix, random primers, enzymes, and even the clean-up columns and collection tubes. OGT also offers analysis software for easier interpretation of results with data exchange for comprehensive, state-of-the-art cytogenetic profiling, and comprehensive training for customers of its CytoSure arrays.
More: www.ogt.co.uk
PANalytical
Omnian Standardless XRF Analysis Package
According to PANalytical, its new Omnian standardless XRF analysis package is designed for rapid quantification of unknown samples or for situations where certified standards that match specific sample characteristics are not available.
More: www.panalytical.com
Axios FAST Simultaneous XRF System
The new Axios FAST simultaneous XRF system comprises pioneering technology to ensure unrivaled speed and throughput for routine analysis and dedicated real-time process control. Axios FAST is equipped with PANalytical's SST-mAX X-ray tube, which uses ZETA technology to eliminate the effects of X-ray tube aging on intensity.
More: www.panalytical.com
PerkinElmer
Input Beam Accessory for Spectrometers
According to PerkinElmer, its new input beam accessory expands the applications of its Spectrum 400 and 100 Series spectrometers by allowing them to be used for analysis of external emitting samples such as flames, hot or warm samples, and gases from furnaces.
The accessory also can expand capability and increase practicality by being used as part of a custom apparatus, such as a telescope or external optical set-up.
More: www.perkinelmer.com/ftir
PerkinElmer and Agilent Technologies
EZChrom Elite for Clarus
PerkinElmer has developed interface software for Agilent's EZChrom Elite chromatography data system to control PerkinElmer's Clarus family of gas chromatographs (GCs). Once installed, the interface software enables existing EZChrom Elite users to control PerkinElmer's Clarus GCs, including the 600, 500, and 400 models, on existing networked installations.
More: www.perkinelmer.com
Phenomenex
SFC Columns for Analytical and Preparative Applications
According to Phenomenex, its new line of supercritical fluid chromatography (SFC)-certified columns bring new phases and selectivities to SFC separations, expanding the application of this technology to analytical and preparative applications.
Phenomenex's new SFC offerings represent three of the company's media brands including the Luna hydrophilic interaction liquid chromatography columns with unique, cross-linked diol chemistry for analysis of polar metabolites; Synergi Polar-RP (ether-linked phenyl phase) for polar and aromatic analysis; and the new Lux chiral phases.
More: www.phenomenex.com
Porvair Filtration Group
BioVyon Products
A new range of BioVyon products are now available with immobilized Protein A for use in IgG antibody purification. BioVyon Protein A microplates and columns offer a simple and rapid method for antibody purification. The new products provide a consistent recovery of IgG antibody that is independent of the flow rate during loading. Unlike existing bead-based technologies, there are no slurries to equilibrate and pour into columns, so the protein purification process is accelerated.
BioVyon Protein A mini and micro columns provide consistent recoveries of purified IgG. The high purity and recoveries are consistent in multiple extractions using the same column or from column to column. Each mini column has a capacity of approximately 2.5 mg IgG (micro—10-μg IgG) and can be reused several times with appropriate washing steps before the performance degrades. The unique BioVyon solid-state media means that performance is not diminished at flow rates as high as 3 mL/min, resulting in faster purifications. For small-scale preparations, such as screening for IgG expression across a series of cell lines, in which sample is limited and high recoveries are needed, the consistency of BioVyon Protein A mini and micro columns enables unmatched performance.
More: www.biovyon.com
BioVyon C18 Silica Columns and Microplates
A new range of BioVyon C18 silica columns and microplates from Porvair Filtration Group are for use in low-volume solid-phase extraction (SPE) assays. According to Porvair, traditional packed bed SPE columns and microplates perform relatively inefficiently when using the shallow sorbent beds necessary to get good recovery from smaller sample volumes. By immobilizing the C18 sorbent within the porous BioVyon polymer, a novel, high surface area matrix that provides unmatched control of flow rate is created, and the immobilized C18 sorbent cannot form liquid channels and does not require inert frits to support it.
BioVyon C18 is initially being offered in 96-well microplates as a 10 mg per well loading suitable for low-volume bioassay preparation and clean-ups. In the 1-mL cartridge format, BioVyon C18 is available in a choice of 12.5, 25, and 50-mg loadings.
More: www.biovyon.com
BioVyon Protein Purification and Solid-Phase Extraction Microplates and Columns
A new range of solid-state sample preparation products from Porvair enables accelerated purification of biological molecules and materials. Porvair has created a new highly purified porous polyethylene material. Using novel ActiVyon technologies, Porvair has chemically modified and activated the polymer to create a series of new materials used in the production of a new range of BioVyon protein purification and solid-phase extraction (SPE) microplates and columns.
BioVyon Protein A products offer a new, simple, and rapid method for antibody purification. Unlike existing protein purification technologies there are no time-consuming slurries to equilibrate and pour into columns. Just remove the BioVyon Protein A plate or column from its packaging, add buffer, and begin purification. Unlike traditional gel-based products, BioVyon Protein A 96-well plates are fully compatible with robotic systems.
The new BioVyon SPE products for SPE feature a novel solid-state SPE technology and superior resin-packed microplates and columns, which result in lower hold-up volumes, better well-to-well and column-to-column consistency, and thus better recoveries.
More: www.biovyon.com
Porvair Sciences
CoolTrough Reagent Reservoir Holders
According to Porvair Sciences, its new CoolTrough range of chilled reusable reagent reservoir holders is designed to preserve the integrity of reagents and extend working time at 0–5 °C. CoolTrough holders chill or freeze quickly, are reusable, and provide full and consistent reservoir cooling without the contamination risks or inconvenience of ice baths. CoolTrough holders come with disposable 100-mL polypropylene liners. Where sample cooling is not required, reusable reagent holders without coolant are available for use with the same disposable polypropylene liners.
More: www.porvair-sciences.com
Pattern Adhesive Films
This new range of high integrity seals for 96- and 384-well microplates have adhesive printed in a pattern to exactly match the shape of the microplate wells. Consequently, no adhesive comes into contact with samples or solvent, and piercing a pattern adhesive film with a single or multichannel pipettor or robotic probe does not risk contaminating your sample with residual adhesive.
More: www.porvair-sciences.com
MiniVAP Sample Concentrator
Porvair's new 24-well MiniVAP sample concentrator is designed for laboratories looking to remove the traditional drug discovery bottleneck of solvent evaporation in 24-well microplates before analysis or reconstitution in buffer. The 24-well MiniVap takes just minutes to dry down a plate. Compact in design, the MiniVap will fit into any standard fume cupboard and is considered ideal for labs tasked with smaller numbers of individual 24-well plates.
More: www.porvair-sciences.com
24-Position MiniVap
Compact in design, the new 24-position MiniVap is purpose designed for R&D laboratories tasked with handling smaller numbers of tubes and vials (up to 3 mL volume) as well as 24-well microplates. Simultaneously injecting heated nitrogen directly into each of the tubes, vials, or wells of a microplate enables the 24-position MiniVap to provide fast “dry down” times.
More: www.porvair-sciences.com
QIAGEN
PreAnalytiX PAXgene Tissue System
According to PreAnalytiX, its PAXgene Tissue System enables users to perform histology, immunohistochemistry and stabilized RNA, miRNA, and DNA extractions from one sample without worrying about a compromised workflow.
The PAXgene Tissue System combines tissue fixation with nucleic acid stabilization, enabling users to get the most information from samples. The stabilized nucleic acids make it possible for researchers to get optimal morphology and molecular results from one sample.
The system has two components—a tissue container and tissue kits. The dual-chambered container is prefilled with two reagents: PAXgene Tissue Fix for fast penetration and fixation, and PAXgene Tissue Stabilizer for storage and transport. The fixation process uses a standard histocasette with a fixative that is an alternative to formalin and is stopped by transferring the sample into the stabilizer. Fixation time is standardized at 2–4 h. The sample is stable in the PAXgene Tissue Stabilizer for transport and storage before processing. Tissue can then be paraffin embedded and processed in pathology workflows. After tissue has been stabilized in PAXgene tissue containers (and optionally paraffin embedded), RNA, miRNA, and DNA can be purified using the PAXgene tissue kits.
More: www.qiagen.com
Rotor-Gene Q Real-Time PCR Cycler
According to QIAGEN, its new Rotor-Gene Q Real-Time PCR Cycler and its centrifugal rotary design make it the most precise and versatile real-time cycler currently available. It offers unmatched thermal and optical performance; high-resolution melting and fast PCR on one instrument, suitable for many emerging applications; unbreakable tubes and flexible formats; minimal maintenance and calibration requirements for maximum ease of use; and versatile software that enables real-time analysis of leading-edge procedures.
More: www.qiagen.com
QIAgility
The new QIAgility offers reproducible results for real-time PCR assays; rapid and reliable PCR set-up that eliminates manual pipetting steps; can be operated via computer with easy-to-use software; and readies samples for immediate use in downstream applications.
More: www.qiagen.com
EZ1 Advanced XL
The EZ1 Advanced XL is a low-throughput alternative for nucleic acid purification. This new platform is an enhanced version of the EZ1 Advanced that now enables users to process up to 14 samples simultaneously and receive results quickly. Easy-to-use workstations feature error-free protocol selection and worktable set-up. The EZ1 Advanced XL uses EZ1 Kits with preprogrammed protocols on EZ1 cards.
More: www.qiagen.com
Radleys
Applications Bulletin: Acid Chloride Coupling Reaction Using Ph Controlled Addition
A new applications bulletin from Radleys (TDS05S) describes how a leading agrochemical research laboratory used the Lara Controlled Laboratory Reactor (CLR) to perform a difficult acid chloride coupling reaction using pH controlled addition.
In the described reaction, acid chloride is automatically fed over a 3-h period into the Lara CLR together with simultaneous sodium hydroxide addition to control the pH in the region of 6.5. The coupling of the acid chloride to the sodium salt of an oxy anion is a biphasic reaction in which the temperature has to be maintained at 10 °C to maximize yield of the final ester product. Efficient stirring of the coupling reaction is essential as the product forms as a thick slurry.
According to Radleys, the experimental data demonstrate that the Lara CLR is well suited for automating chemistry of this complex nature where pH control, reaction viscosity, and isothermal temperature control were all challenges to maximizing yield. With minimal training the users were quickly able to set up the system, get the unit running and reproducibly perform the acid coupling reaction to generate high yields of the ester product.
More: www.lara-clr.com
Breeze Temperature Control System
The Breeze low-cost temperature control system is designed to deliver rapid heating and cooling of reactions from −30 to +165 °C. When combined with a standard Heat-On block and suitable thermoregulator, the Breeze replaces the need for a separate cooling reservoir, oil bath or heating mantle, and delivers a new level of temperature control of reactions carried out in single round bottom flasks from 10 mL to 5 L.
More: www.radleys.com or www.lara-clr.co.uk
RheoSense
VROC-D Chip
This new D chip expands the measurement ranges offered by existing chips to high shear rate viscosity measurements. The new D chip allows viscosity measurement at shear rates as high as 1,000,000 1/s for low viscosity liquids. The chip is also suitable for high viscosity liquid.
More: www.RheoSense.com
RTS Life Science
Free Sample Management Automation Audit
RTS's new automation audit is a simple six-question form that users can complete free of charge to assess the impact of automating a sample library.
More: www.rtslifescience.com
Starna
Type 19FL Ultra-Micro Volume Fluorescence Lens Cell
A new ultra-micro volume fluorescence lens cell from Starna addresses requirements for conducting clinical/biochemical/pharmaceutical studies by performing UV/Visible spectrofluorometer analysis on smaller volume samples of typically 5 μL or less, providing a practical solution for when samples cannot be prepared in or diluted to larger volumes.
Starna's new Type 19FL ultra-micro cell, which avoids the need for dilution, is considered well suited for providing analysis in volumes typically handled in molecular biology and forensics applications, and for proteomics applications where the sensitivity of the cell is sufficiently high to measure native fluorescence of proteins prepared in microliter quantities. The cell design also allows the majority of the sample to be recovered.
The new ultra-micro cell is about 5% less sensitive when compared with a conventional 10 mm path length cell. According to Starna, however, the difference is much less than the loss in sensitivity encountered when diluting a sample to the required minimum volume (about 300 μL) for full centimeter-square cells, and the lens design offers greater efficiency than that of a standard micro cell of equivalent geometry.
More: www.starna.com
Symyx Technologies
Symyx Notebook 6.1
This second major release of Symyx Notebook is designed for capturing, querying, and reporting on numerous experimental methods and data across the spectrum of experimentation encountered by analytical chemists and biologists. The configurable Symyx Notebook 6.1 makes it easy to find information quickly, and enables users to share experimental notebook entries across project teams, departments, and contract research organizations. Data can be captured directly from laboratory instruments, and data from past experiments can be quickly and easily located and shared.
Chemists can draw and edit complex chemical structures using Symyx Draw 3.1 software, which is embedded in Symyx Notebook. Flexible notebook templates and text searching support the rapid creation and querying of experimental write-ups for any audience. Scientists can quickly generate materials tables by entering data manually into Symyx Notebook, capturing data directly from lab balances, or taking advantage of Symyx Notebook's auto-fill data population capability. Out-of-the-box integration with laboratory information management systems and data repositories such as Waters NuGenesis scientific data management system accelerate the transfer of analytical results into notebook documents while reducing data transcription and omission errors. By augmenting experimental write-ups with hyperlinks to many related experiments, Symyx Notebook 6.1 makes it possible to trace the reuse of materials from one experiment to another and quickly identify experiments that have been referenced in colleagues' work.
Workflow tools in Symyx Notebook 6.1 streamline document reviews by automatically highlighting invalid or overridden data, out-of-range values, and required fields that lack data entries. R&D organizations can easily control read-and-write security at the template, section, or document level. Enterprise-level security, comprehensive versioning, and 21CFR11-compliant electronic signatures and audit trails support good practices compliance in both regulated and nonregulated environments.
More: www.symyx.com/elnanalytical and www.symyx.com/elnbiology
Symyx Assay Explorer 3.2
According to Symyx, this new biological information management system enables users to capture experimental data and methodologies into a central repository where they are rapidly and easily accessible for improved querying, collaboration, and decision making. Assay Explorer 3.2 offers flexible reporting and display functionality, including chemical structures, bar charts, histograms, dose–response curves, and scattergrams.
More: www.symyx.com
Powdernium Storage Vial
Powdernium SV (Storage Vial) is a new shaker powder dispense technology that Symyx considers ideal for novel applications such as compound management, walk-up sample preparation, and reference standards preparation. Powdernium SV acts as a hybrid vial hopper and storage vessel that enables low-cost storage without the requirement to subdivide materials, helping to save and optimally manage precious resource materials.
More: www.symyx.com
Symyx Metabolite Database
According to Symyx, the latest release of its Metabolite Database is the largest and most comprehensive collection of drug metabolism data in the world, and is now available via the Symyx Isentris data access, analysis, and decision support system, as well as the Web-based DiscoveryGate content platform.
SPRESI Structure and Reaction Database
Also now available via the Symyx Isentris system is the SPRESI structure and reaction database from InfoChem. According to Symyx, in combination with existing Symyx reaction databases, which provide extensive coverage of reactions, detailed experimental methodology, and links to online citations and in-house reaction data, the SPRESI database offers synthesis chemists a high-quality and cost-effective synthesis planning solution.
More: www.symyx.com
Syrris
Reactor Master Basic and Pro
The new Reactor Master from Syrris is for automating jacketed reactor systems and data logging without PC software. Designed specifically for use with chemical synthesis equipment in chemical laboratories, this system can automate circulators or chillers, stirrers, thermocouples, and resistance temperature detectors from virtually any manufacturer via the easy-to-use control knob, and data can be viewed in real time and exported for off-line analysis.
The Reaction Master Basic is easily controlled using a multifunction knob that allows set points, ramps, or sophisticated profiles for temperature and stirring speed. A compact design enables it to fit conveniently by the reactor system and all parameters, such as stirrer speed and torque are displayed on the LCD screen in real time. These data are continually saved to one csv file, which is easily exported via a USB stick.
The Reaction Master Pro incorporates all the benefits of the basic model plus closed loop (PID) control of the circulator for a uniform reaction temperature to be accurately maintained, minimizing the chances of variability. An entry-level data analysis PC software upgrade enables graphs to be easily generated. The full PC software version allows complex recipe control, real-time data plotting, and control of third-party hardware.
More: www.syrris.com
Thermo Fisher Scientific
Application Note: Rapid Analysis of Impurities in Silver Using a Separate Sampling and Excitation Accessory and Thermo Scientific iCAP 6500 Duo
A unique solution for fast and efficient impurity analysis of solid metals, including steels, platinum group metals, gold and other conductive materials is described in a new application note from Thermo. Combining the Thermo Scientific iCAP 6500 Duo ICP emission spectrometer with a Separate Sampling and Excitation Accessory, the solution enables close monitoring of all stages of the silver refinery process. The iCAP 6000 Series enables the sensitive, multielement determination of impurities at ppb and sub-ppb levels in liquid-phase matrices and by adding the SSEA accessory, solid-phase metallic matrices can also be analyzed with only minimal sample preparation.
More: www.thermo.com/icap
Application Note: Accurate Analysis of Low Levels of Mercury in Fish By Hydride Generation AA
This new application note from Thermo demonstrates how its iCE 3000 Series AA spectrometers and VP100 vapor generation accessory can accurately detect trace levels of mercury in fish, and includes details about reagents, sample preparation, and instrument conditions.
More: www.thermo.com/ice
Application Note: Quantitative Analysis of Pseudoephedrine Tablets by UHPLC/MS
A new application note from Thermo demonstrates a fast and reliable UHPLC/MS method to effectively separate and identify pseudoephedrine, ephedrine, amphetamine, methamphetamine, and 3,4-MDMA. The note details UHPLC/MS methodology and instrumentation for high-throughput separation and identification of components in illicit drug samples using the Accela UHPLC system and MSQ Plus single quadrupole mass spectrometer.
More: www.thermo.com/appnotes
Identification of Dioxins in Pork Products
According to Thermo Fisher Scientific, its high-resolution gas chromatography mass spectrometry (GC/MS) solutions are suitable for dioxin analysis in foods. Even difficult sample types with heavy matrix effects can be successfully analyzed. In addition, the Thermo Scientific TSQ Quantum GC can be used to screen for dioxins. By identifying foods that do not contain dioxins, the number of samples that must be analyzed using HRGC/HRMS is reduced.
Extended X-ray Spectrometry Petrochemical Solutions
A new series of X-ray solutions and resources targeted toward the petrochemical industry include a portfolio of X-ray spectrometry equipment, a new demonstration laboratory in Sugar Land, TX, and a Web portal that presents analytical capabilities of Thermo Scientific X-ray spectrometry systems for the petrochemical industry.
More: www.thermo.com/xpetro
TITAN 4000 NSX Analyzer
According to Thermo, its new streamlined TITAN 4000 Total Nitrogen/Sulfur/Chlorine (NSX) analyzer is up to 60% smaller than competing analyzers, and offers refinery and petrochemical markets superior sample introduction and enhanced oxidative combustion performance. Its working range covers total NSX applications from low ppb to high ppm concentrations. The TITAN 4000 NSX analyzer can analyze TN/TS samples within 2 min and TX samples in under 4 min. A unique chromium-plated copper spray injection design can inject high boiling point component samples without blocking the injection system. The sample introduction and combustion technology, with pre-soot detection ensures optimum analysis and result precision, reducing lead time and minimizing matrix effects.
More: www.thermo.com/titan4000
MaxQ 8000 Stackable Shakers
According to Thermo, its new MaxQ 8000 stackable shakers offer several unique features, including run points and set points for temperature, speed, and time, displayed simultaneously for convenient run cycle monitoring. A built-in HEPA filter minimizes the chance of cross-contamination and ensuring that air inside the chamber remains clean. The fold-down door with ergonomically designed handle allows the shaker platform to slide out, enabling easy access for loading and unloading of samples. Safety is ensured by a flip-down handle/latch on the quick-release base, preventing the shaker from running if the platform is not secure. In addition, all stacking hardware is included.
More: www.thermofisher.com
ThermoFlex Series of Recirculating Chillers
According to Thermo, its ThermoFlex chiller platform is an easy-to-use, easy-to-maintain, high-performance chiller platform configurable to the most demanding applications. Each chiller includes air and water filters that can be changed while the unit is in operation and an intuitive user interface for ease of operation. Units are now available with cooling capacities up to 10,000 W.
MBP ART Barrier Tips
MBP brand ART barrier tips are now available from Thermo in two new packaging configurations. The ART Reload System combines individually packaged barrier tip reload inserts with space-saving hinged racks This sterile, barrier tip reload system features a “push down” blister tub that clips the inserts securely into the hinged rack without exposure to the environment for contamination-free transfer of the pipette tips into the tip racks.
More: www.mbpinc.com
Nalgene-Certified Clean PETG Containers
According to Thermo, these new containers are suitable for pharmaceutical and biotechnology applications requiring the processing and storage of bulk intermediates and critical reagents, such as vaccine and protein therapeutic preparations. The containers provide excellent gas barrier properties to minimize pH shifts, resins used to produce these containers are free of animal-derived components, and the bottle and closure system is guaranteed leakproof.
More: www.nalgenelabware.com
Molecular Bioproducts BioRobotix 384-Well Automated Pipette Tips
384-Well pipette tips are now available from Thermo for the Velocity11 VPrep and Bravo liquid-handling workstations. All pipette tips are certified RNA, DNA, RNase, DNase, Pyrogen, and ATP free are offered in sterile and nonsterile formats, and have low percent coefficient of variation specifications to ensure precise liquid-handling performance. In addition, antistatic trays reduce static charge so tips mount straight and eject with consistent precision. Tips are lot tested on a Velocity11 workstation and must pass an extensive 15-point quality control program.
More: www.mbpinc.com
Torrey Pines Scientific
EchoTherm Digital Hot Plates and Digital Stirring Hot Plates
The EchoTherm Models HP51 and HS51 Digital Hot Plates and Digital Stirring Hot Plates are rugged and designed for large samples. The units feature a membrane keyboards and full function liquid crystal displays where all parameters are continuously visible. These units can store two of the user's favorite settings in memory for instant recall and use at any time.
Both tops are 12 in. by 12 in. square. The ceramic top has a 1400-W heater. The aluminum top has a 1200-W heater. Temperatures can be set up to 450 °C on the ceramic topped units and to 400 °C on cast aluminum tops. The units are readable and settable to 1 °C. Accuracy is 1% over the entire temperature range. Temperature control is by PID software and is controlled to +1 °C or °F. Stirrer speeds can be set from 100 to 1500 rpm. The built-in timer can be set to 99 h and is readable to 1 s.
Uniqsis
Multiple Experiment Package for FlowSyn
A new optional Multiple Experiment Package integrates the FlowSyn continuous flow reactor with a Gilson FC203B or FC204 fraction collector to produce a very compact, cost-effective system capable of running up to 10 sequential experiments with different reaction times, temperatures, and reagent ratios. Everything, including the fraction collector, is controlled via the FlowSyn user interface, so no separate PC is needed.
Two operating protocols are available. In fractionation mode, reaction products are collected in programmed fractions. In the unique optimization mode, product is collected, during a programmable window, in a single vial. A small aliquot can also be taken during the experiment and delivered into an LC–MS vial where it can be mixed with a quench reagent so that reaction progress can be measured.
More: www.uniqsis.com
VirTis
Control Upgrades
Modern control upgrades for a wide variety of older freeze dryers are now available from VirTis. According to VirTis, the mechanical components of most freeze dryers can last in excess of 30 years, but controller platforms are typically updated on a regular basis to increase functionality. VirTis provides upgrades and refurbishments for all of its controllers including Sentry, Wizard, Encore, and Maestro. In facilities where multiple freeze dryers are in operation and a single control platform is advantageous, a VirTis controller upgrade program can be implemented on both the VirTis dryers and other brands of freeze dryers.
More: www.virtis.com
Viscotek
DSV Automation
According to Viscotek, it is unique in providing fully automated, temperature-controlled measurement of polymer dilute solution viscosity (DSV). The DSV system incorporates a dual capillary viscometer, and Viscotek's Vortex automated sample preparation and injection system. It operates with a pump-driven closed loop to minimize solvent exposure and reduce sample size.
More: www.viscotek.com
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Activotec expanded its Cambridge, UK headquarters with an investment in new sales and production staff.
Adept Technology moved its headquarters to a new location in Pleasanton, CA.
AdvanDx received FDA 510(k) clearance for its Escherichia coli/Pseudomonas aeruginosa PNA FISH test to identify E. coli and/or P. aeruginosa directly from positive blood cultures.
Applied Biosystems and scientists from the Baylor College of Medicine Human Genome Sequencing Center (HGSC), summarized their collective contribution to the first data release of the 1000 Genomes Project. As a commercial participant, and as part of Applied Biosystems' collaboration with the HGSC, more than 460 gigabases of unique mappable sequence data was generated by the SOLiD System, representing 65% more than the target for the two organizations when the collaborative project was conceived.
Magnus Ekerot joined Beijer Electronics as managing director. Previously, he was with Axis Communications as managing director responsible for Middle and Central/Eastern Europe.
BioFocus extended its drug discovery agreement with Eli Lilly through 2009. Under the terms of the agreement, BioFocus will identify active compounds by screening of Lilly's library compounds.
BioGenes was chosen as a new partner of cNEUPRO, an EU-funded research project to analyze neurodegenerative diseases and discover novel biomarkers to improve early and differential diagnosis of Alzheimer's dementia. BioGenes provides laboratory facilities and key personnel to develop specific monoclonal antibodies against novel neurochemical dementia biomarkers in blood and cerebrospinal fluid identified during the project.
BioTek Instruments is now in the United Kingdom, focusing on growing BioTek's brand and direct customer base in the UK while supporting the efforts of Thermo Fisher UK related to BioTek's microplate instruments and technologies.
deCODE genetics received a clinical laboratory license from the State of California.
Jörn Aldag resigned from his position as President and Chief Executive Officer of Evotec.
Using a digital array from Fluidigm, the Fred Hutchinson Cancer Research Center developed a method for the early detection of a common mechanism of resistance on drug treatment for chronic myeloid leukemia. Researchers were able to detect a specific point mutation, which is associated with acquired resistance to the drugs Gleevec (imatinib mesylate), Sprycel (dasatinib), and Tasigna (nilotinib), as much as 100 days earlier than standard tests.
Fluidigm Europe announced that LGC purchased a BioMark System for genetic analysis in its UK laboratories. The system, with its integrated fluidic circuit technology, adds digital PCR to LGC's existing range of capabilities, which includes quantitative PCR, genotyping, gene expression, copy number variation, and absolute quantification for sequencing.
Fluxion Biosciences signed an exclusive distribution agreement with IUL Instruments to handle sales and service in Germany and Austria of Fluxion's BioFlux research tools for live cell image analysis in drug discovery.
Franek Technologies received ISO 9001:2000 Certification.
Graffinity Pharmaceuticals entered into a research collaboration with Elan Pharmaceuticals, and under the terms of the agreement, Graffinity will receive technology access fees and success payments for the generation of novel small molecule hits against a number of drug targets. Elan will gain access to Graffinity's proprietary fragment-based drug discovery technology, which uses chemical microarrays and surface plasmon resonance to screen for small molecule fragments that bind to a variety of drug targets. The identification of novel modes of action and chemistry is a major focus of the collaboration.
IDBS announced that Cancer Therapeutics CRC selected both E-WorkBook and ActivityBase to manage its drug discovery and development on a global multisite basis; and that the Immunovirology Division of the French Atomic Energy Agency (Commissariat à l'Ènergie Atomique) selected E-WorkBook for Biology (BioBook) to capture, collate, analyze, and share data across its multiuser research projects.
Using 2 MEDIAJET 540 Automatic Media Preparation Systems from INTEGRA Biosciences, Italy's Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER) filled more than 1.3 million perfect petri dishes without stopping over the last year.
LabAnswer acquired Laboratory Automation Solutions.
Labcyte was issued U.S. Patent 7,405,072, which uses the unique advantages of moving liquids with sound to transfer fluids within a sealed container, free from any physical contact. This process can be applied to the testing of pathogens and other dangerous fluids.
Navitar appointed Patrick Buvé as regional sales manager for Europe, Middle East, and Africa. Buvé is based in Belgium and oversee Navitar staff in Germany and the U.K. Before joining Navitar, Buvé was the European sales manager for CCS Europe NV.
Navitar sold its coating division, Navitar Coating Labs, to its division president, Dan Coursen, who had been with the company for over 35 years. Its name was changed to Coursen Coating Labs.
Novozymes Biopolymer won the Gold Innovation Award at CPhI worldwide conference for its novel form of hyaluronic acid HyaCare. The award recognizes exceptional work in developing research and technology in the pharmaceutical manufacturing industry.
Novozymes Biopharma and Upperton Limited announced that the European Patent Office confirmed the official Decision to Grant a European patent for their targeted drug delivery joint patent application (European patent No 1605979). This new patent describes methods of conjugating antibodies and other targeting agents to protein carriers by means of a heterobifunctional linker for the delivery of large quantities of drugs and other agents to selected sites in the body.
Oxford Expression Technologies (OET) and Eden Biodesign signed a co-marketing agreement allowing OET to offer its customers access to Eden Biodesign's process development, clinical trial cGMP manufacturing, and analytical development services. In return, Eden Biodesign's customers will have access to OET's range of baculovirus capabilities to meet their individual protein expression requirements.
Oxford Gene Technology announced a collaboration with Optra Systems to develop visualization and analysis software for data generated from high-resolution scanners.
In a series of programs spotlighting innovative local companies, Dutch regional TV featured PANalytical in a program that challenged students to identify which Christmas chocolate had been contaminated with a sleep-inducing drug. The chocolate was successfully analyzed using PANalytical's X'Pert PRO Multi-Purpose Diffractometer.
PerkinElmer acquired Opto Technology, adding optical subsystems to PerkinElmer's portfolio of high brightness LED components.
Tom Clement joined QIAGEN as vice president of regulatory and clinical affairs. He joins the company from Roche Molecular Systems, where he was vice president of quality and regulatory. Stephane Perrey joined QIAGEN KK as president. He follows Kazuo Tokushige who retired. Dr. Perrey joined the company from Third Wave/Hologic Japan and previously held various positions in the Japanese in vitro diagnostic industry, especially in infectious diseases segments.
Roche Diagnostics received FDA approval for its HBsAg and Anti-HBs assays for use on the cobas 6000 analyzer series and the cobas e 411 analyzer.
RTS Life Science supplied its A3 SmaRTStore as part of the commercial scale Biorepository at the Broad Institute. The Broad Institute's Biological Samples Platform (BSP) is a sample management program with expertise in sample storage and processing technology, procedures for collection and use of human samples in biomedical research, histological analyses of human tissues, and the development of Laboratory Informatics Management Systems for detailed sample tracking. A poster detailing the BSP is available free of charge at www.broad.mit.edu.
Hilton Nicholson joined SIXNET as president and CEO, succeeding Steve Schoenberg who continues to serve on the company's board of directors. Mr. Nicholson came to SIXNET from ADC, where he was president of the Network Solutions Business Unit.
Symyx Technologies announced that Schering-Plough licensed Symyx Notebook to support the company's initiative to equip its scientists across global R&D operations with a single, enterprise-wide electronic lab notebook.
Thames Water, the UK's largest water and wastewater services company, chose the Thermo Scientific iCAP 6000 Series ICP emission spectrometer for the detection and quantification of trace elements in drinking water samples. Thames Water carries out over half a million water quality tests each year to ensure the quality of its drinking water and environmental compliance of treated wastewater.
David Newble was appointed CEO Designate of The Automation Partnership. He succeeds Dr. Andy Morffew.
TTP LabTech successfully completed a major laboratory automation project with AstraZeneca's research facility in Södertälje. The project, which took over 3 years to complete, involved the design and build of a fully automated system for salt and polymorph screening of novel compounds.
Pavel Uhlir joined UNIConnect as its director of customer service and engineering, a new position within the company. Most recently, Uhlir served as a software engineer at Aculis.
Call for Papers
LabAutomation2010
ALA is now accepting abstract proposals for LabAutomation2010 podium and poster presentations in five key education tracks: detection and separation, high-throughput technologies, informatics, micro- and nanotechnologies, and evolving applications of laboratory automation featuring agriculture and food. One podium presenter will win $10,000 as the 2010 ALA Innovation Award winner, and 10 finalists will travel to Beijing, China, to present their work at ACHEMAsia2010, June 1–5.
The ALA Lab Automation2010 conference and exhibition will be held January 23–27 in Palm Springs, CA. For complete program information and access to the online abstract submissions system, visit www.labautomation.org.
Journal of the Association for Laboratory Automation
JALA is the only peer-reviewed, scientific journal devoted exclusively to the research, development, and application of technologies in scientific laboratories. Manuscripts are accepted on an ongoing basis from ALA members and nonmembers.
JALA manuscript abstracts are indexed by Analytical Abstracts, Chemical Abstracts CAS+, CINAHL, Compendex, EMBASE/Excerpta Medica, Google Scholar, Inspec, ProQuest CSA Tech Research Database, Scifinder, Scirus, and Scopus. Abstracts and full text articles also are available at JALA Online and Elsevier ScienceDirect.
Lab automation professionals are invited to showcase their achievements by submitting method-focused scientific papers for publication consideration. Manuscript guidelines and submission information are available at www.labautomation.org/journal/submissions.cfm.