Chapters 6 and 7

Abraham R.T. , 2001. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15, 2177–2196.

Abraham R.T. , 2002. Checkpoint signalling: focusing on 53BP1. Nat. Cell Biol. 4, E277–E279.

Adams J.M. , 2003. Ways of dying: multiple pathways to apoptosis. Genes Dev. 17, 2481–2495.

Adams L.M. Ethier S.P. Ullrich R.L. , 1987. Enhanced in vitro proliferation and in vivo tumorigenic potential of mammary epithelium from BALB/c mice exposed in vivo to gamma-radiation and/or 7,12-dimethylbenz[a]anthracene. Cancer Res. 47, 4425–4431.

Akleyev A.V. Lyubchansky E.R. , 1994. Environmental and medical effects of nuclear weapon production in the Southern Urals. Sci. Total Environ. 142, 1–8.

Amundson S.A. Chen D.J. , 1995. Ionizing radiation-induced mutation of human-cells with different DNA repair capacities. Phys. Chem. Biochem. Biol. Tech. Process. 18, 119–126.

Amundson S.A. Chen D.J. , 1996. Inverse dose-rate effect for mutation induction by gamma-rays in human lymphoblasts. Int. J. Radiat. Biol. 69, 555–563.

Ashcroft M. Kubbutat M.H. Vousden K.H. , 1999. Regulation of p53 function and stability by phosphorylation. Mol. Cell Biol. 19, 1751–1758.

Ashkenazi A. , 2002. Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat. Rev. Cancer 2, 420–430.

Auckley D.H. Crowell R.E. Heaphy E.R. , 2001. Reduced DNA-dependent protein kinase activity is associated with lung cancer. Carcinogenesis 22, 723–727.

Azzam E.I. Raaphorst G.P. Mitchel R.E.J. , 1994. Radiation-induced adaptive response for protection against micronucleus formation and neoplastic transformation in C3H 10T1/2 mouse embryo cells. Radiat. Res. 138, S28–S31.

Azzam E.I. de Toledo S.M. Raaphorst G.P. Mitchel R.E. , 1996. Low-dose ionizing radiation decreases the frequency of neoplastic transformation to a level below the spontaneous rate in C3H 10T1/2 cells. Radiat. Res. 146, 369–373.

Azzam E.I. de Toledo S.M. Gooding T. Little J.B. , 1998. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat. Res. 150, 497–504.

Azzam E.I. de Toledo S.M. Little J.B. , 2001. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells. Proc. Natl. Acad. Sci. USA 98, 473–478.

Azzam E.I. de Toledo S.M. Spitz D.R. Little J.B. , 2002. Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from α -particle-irradiated normal human fibroblast cultures. Cancer Res. 62, 5436–5442.

Azzam E.I. de Toledo S.M. Little J.B. , 2003a. Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stresses. Cancer Res. 63, 7128–7135.

Azzam E.I. de Toledo S.M. Little J.B. , 2003b. Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect. Oncogene 22, 7050–7057.

Bailey S.M. Meyne J. Chen D.J. , 1999. DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes. Proc. Natl. Acad. Sci. USA 96, 14899–14904.

Bailey S.M. Cornforth M.N. Kurimasa A. Chen D.J. Goodwin E.H. , 2001. Strand-specific postreplicative processing of mammalian telomeres. Science 293, 2462–2465.

Bailey S.M. Cornforth M.N. Ullrich R.L. Goodwin E.H. , 2004. Dysfunctional mammalian telomeres join with DNA double-strand breaks. DNA Repair (Amst.) 3, 349–357.

Baker G.S. Hoel D.G. , 2003. Corrections in the atomic bomb data to examine low dose risk. Health Phys. 85, 709–720.

Banin S. Moyal L. Shieh S. , 1998. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281, 1674–1677.

Barcellos-Hoff M.H. , 1996. Latency and activation in the control of TGF-beta. J. Mamm. Gland Biol. Neoplasia 1, 353–362.

Barcellos-Hoff M.H. , 1998. How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissues. Radiat. Res. 150 (Suppl.), S109–S120.

Barcellos-Hoff M.H. , 2001. It takes a tissue to make a tumor: epigenetics, cancer and the microenvironment. J. Mamm. Gland Biol. Neoplasia 6, 213–221.

Barcellos-Hoff M.H. Brooks A.L. , 2001. Extracellular signaling through the microenvironment: a hypothesis relating carcinogenesis, bystander effects, and genomic instability. Radiat. Res. 156, 618–627.

Barcellos-Hoff M.H. Ewan K.B. , 2000. Transforming growth factor-beta and breast cancer: mammary gland development. Breast Cancer Res. 2, 92–99.

Barendsen G.W. , 1978. Fundamental aspects of cancer induction in relation to the effectiveness of small doses of radiation Late Biological Effects of Ionizing Radiation, Vol. II. IAEA, Vienna, pp. 263–276.

Baverstock K. , 2000. Radiation-induced genomic instability: a paradigm-breaking phenomenon and its relevance to environmentally induced cancer. Mutat. Res. 454, 89–109.

Beamish H. Lavin M.F. , 1994. Radio sensitivity in ataxia-telangiectasia: anomalies in radiation-induced cell cycle delay. Int. J. Radiat. Biol. 65, 175–184.

Belyakov O.V. Prise K.M. Trott K.R. Michael B.D. , 1999. Delayed lethality, apoptosis and micronucleus formation in human fibroblasts irradiated with x-rays or alpha particles. Int. J. Radiat. Biol. 75, 985–993.

Belyakov O.V. Malcolmson A.M. Folkard M. Prise K.M. Michael B.D. , 2001. Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts. Br. J. Cancer 84, 674–679.

Belyakov O.V. Folkard M. Mothersill C. Prise K.M. Michael B.D. , 2003. A proliferation-dependent bystander effect in primary porcine and human urothelial explants in response to targeted irradiation. Br. J. Cancer 88, 767–774.

Benson F.E. Baumann P. West S.C. , 1998. Synergistic actions of Rad51 and Rad52 in recombination and repair. Nature 391, 401–404.

Berrington A. Darby S.C. Weiss H.A. , 2001. 100 years of observation on British radiologists: mortality from cancer and other causes 1897–1997. Br J Radiol 74, 507–519.

Bhattacharjee D. , 1996. Role of radioadaptation on radiation-induced thymic lymphoma. Mutat. Res. 358, 223–230.

Bhattacharjee D. Ito A. , 2001. Deceleration of carcinogenic potential by adaptation with low dose gamma irradiation. In Vivo 15, 87–92.

Bishayee A. Rao D.V. Howell R.W. , 1999. Evidence for pronounced bystander effects caused by nonuniform distributions of radioactivity using a novel three-dimensional tissue culture model. Radiat. Res. 152, 88–97.

Bishayee A. Hill H.Z. Stein D. Rao D.V. Howell R.W. , 2001. Free-radical initiated and gap junction-mediated bystander effect due to nonuniform distribution of incorporated radioactivity in a three-dimensional tissue culture model. Radiat. Res. 155, 335–344.

Bissell M.J. Radisky D. , 2001. Putting tumors in context. Nat. Rev. Cancer 1, 46–54.

Bithell J.F. Stiller C.A. , 1988. A new calculation of the carcinogenic risk of obstetric x-raying. Stat. Med. 7, 857–864.

Boice J.D. Jr. Miller R.W. , 1999. Childhood and adult cancer after intrauterine exposure to ionizing radiation. Teratology 59, 227–233.

Boice J.D. Jr. Stone B.J. , 1978. Interaction between radiation and other breast cancer risk factors Late Biological Effects of Ionizing Radiation, Vol. I. International Atomic Energy Agency, Vienna, pp. 231–247.

Boice J.D. Jr. Rosenstein M. Trout E.D. , 1978. Estimation of breast doses and breast cancer risk associated with repeated fluoroscopic chest examinations of women with tuberculosis. Radiat. Res. 73, 373–390.

Boice J.D. Jr. Land C.E. Shore R.E. Norman J.E. Tokunaga M. , 1979. Risk of breast cancer following low-dose radiation exposure. Radiology 131, 589–597.

Boice J.D. Jr. Engholm G. Kleinerman R.A. , 1988. Radiation dose and second cancer risk in patients treated for cancer of the cervix. Radiat. Res. 116, 3–55.

Boice J.D. Jr. Preston D. Davis F.G. Monson R.R. , 1991. Frequent chest x-ray fluoroscopy and breast cancer incidence among tuberculosis patients in Massachusetts. Radiat. Res. 125, 214–222.

Boice J.D. Jr. Tawn E.J. Winther J.F. , 2003. Genetic effects of radiotherapy for childhood cancer. Health Phys 85, 65–80.

Bonner W.M. , 2003. Low-dose radiation: thresholds, bystander effects, and adaptive responses. Proc. Natl. Acad. Sci. USA 100, 4973–4975.

Boothman D.A. Meyers M. Odergaard E. Wang M. , 1996. Altered G₁ checkpoint control determines adaptive survival response to ionizing radiation. Mutat. Res. 358, 143–154.

Bosi A. Olivieri G. , 1989. Variability of the adaptive response to ionizing radiations in humans. Mutat. Res. 211, 13–17.

Bosma G.C. Custer R.P. Bosma M.J. , 1983. A severe combined immunodeficiency mutation in the mouse. Nature 301, 527–530.

Boudaiffa B. Cloutier P. Hunting D. Huels M.A. Sanche L. , 2000a. Resonant formation of DNA strand breaks by low-energy (3 to 20 eV) electrons. Science 287, 1658–1660.

Boudaiffa B. Hunting D. Cloutier P. Huels M.A. Sanche L. , 2000b. Induction of single- and double-strand breaks in plasmid DNA by 100–1500 eV electrons. Int. J. Radiat. Biol. 76, 1209–1221.

Bouffler S.D. Meijne E.I.M. Huiskamp R. Cox R. , 1996a. Chromosomal abnormalities in neutron-induced acute myeloid leukemias in CBA/H mice. Radiat. Res. 146, 349–352.

Bouffler S.D. Breckon G. Cox R. , 1996b. Chromosomal mechanisms in murine radiation acute myeloid leukaemogenesis. Carcinogenesis 17, 655–662.

Bouffler S.D. Meijne E.I.M. Morris D.J. Papworth D. , 1997. Chromosome 2 hypersensitivity and clonal development in murine radiation acute myeloid leukaemia. Int. J. Radiat. Biol. 72, 181–189.

Bouffler S.D. Haines J.W. Edwards A.A. Harrison J.D. Cox R. , 2001. Lack of detectable transmissible chromosomal instability after in vivo or in vitro exposure of mouse bone marrow cells to ²²⁴Ra alpha particles. Radiat. Res. 155, 345–352.

Bouffler S.D. Blasco M.A. Cox R. Smith P.J. , 2001a. Telomeric sequences, radiation sensitivity and genomic instability. Int. J. Radiat. Biol. 77, 995–1005.

Bouffler S.D. Haines J.W. Edwards A.A. Harrison J.D. Cox R. , 2001b. Lack of detectable transmissible chromosomal instability after in vivo or in vitro exposure of mouse bone marrow cells to ²²⁴Ra alpha particles. Radiat. Res. 155, 345–352.

Boulton S.J. Jackson S.P. , 1996. Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J. 15, 5093–5103.

Boulton E. Cleary H. Papworth D. Plumb M. , 2001. Susceptibility to radiation-induced leukaemia/lymphoma is genetically separable from sensitivity to radiation-induced genomic instability. Int. J. Radiat. Biol. 77, 21–29.

Bradbury J.M. Jackson S.P. , 2003. ATM and ATR. Curr. Biol. 13, R468.

Bravard A. Luccioni C. Moustacchi E. Rigaud O. , 1999. Contribution of antioxidant enzymes to the adaptive response to ionizing radiation of human lymphoblasts. Int. J. Radiat. Biol. 75, 639–645.

Brenner D.J. , 1999. Does fractionation decrease the risk of breast cancer induced by low-LET radiation?. Radiat. Res. 151, 225–229.

Brenner D.J. Elliston C.D. , 2001. The potential impact of bystander effects on radiation risks in a Mars mission. Radiat. Res. 156, 612–617.

Brenner D.J. Raabe O.A. , 2001. Is the linear-no-threshold hypothesis appropriate for use in radiation protection?. Radiat. Protect. Dosim. 97, 279–285.

Brenner D.J. Ward J.F. , 1992. Constraints on energy deposition and target size of multiple-damaged sites associated with DNA double-strand breaks. Int. J. Radiat. Biol. 61, 737–748.

Brenner D.J. Doll R. Goodhead D.T. , 2003. Cancer risks attributable to low doses of ionizing radiation — what do we really know?. PNAS 100, 13761–13766.

Brues A.M. , 1958. Critique of the linear theory of carcinogenesis. Science 128, 693–699.

Brues A.M. , 1960. Critique of mutational theories of carcinogenesis. Acta Unio. Int. Contra. Cancrum 16, 415–417.

Burns F.J. Vanderlaan M. , 1977. Split-dose recovery for radiation-induced tumors in rat skin. Int. J. Radiat. Biol. 32, 135–144.

Burns F. J. Albert R.E. Sinclair I.P. Vanderlaan M. , 1975. Effect of a 24-hour fractionation interval on induction of rat skin tumors by electron radiation. Radiat. Res. 62, 478–487.

Cairns J. , 1975. Mutation selection and the natural history of cancer. Nature 255, 197–200.

Cairns J. , 2002. Somatic stem cells and the kinetics of mutagenesis and carcinogenesis. Proc. Natl. Acad. Sci. USA 99, 10567–10570.

Caldecott K. , 2002. Polynucleotide kinase. A versatile molecule makes a clean break. Structure (Camb.) 10, 1151.

Camparoto M.L. Ramalho A.T. Natarajan A.T. Curado M.P. Sakamoto-Hojo E.T. , 2003. Translocation analysis by the FISH-painting method for retrospective dose reconstruction in individuals exposed to ionizing radiation 10 years after exposure. Mutat. Res. 530, 1–7.

Canman C.E. Lim D.S. Cimprich K.A. , 1998. Activation of the ATM kinase by IR and phosphorylation of p53. Science 281, 1677–1679.

Cardis E. Gilbert E.S. Carpenter L. , 1995. Effects of low doses and low dose rates of external ionizing radiation: cancer among nuclear industry workers in three countries. Radiat. Res. 142, 117–132.

Carnes B.A. Grahn D. Thomson J.F. , 1989. Dose-response modeling of life shortening in a retrospective analysis of the combined data from the JANUS program at Argonne National Laboratory. Radiat. Res. 119, 39–56.

Carnes B.A. Groer P.G. Kotek T.J. , 1997. Radium dial workers: issues concerning dose response and modeling. Radiat. Res. 147, 707–714.

Carnes B.A. Gavrilova N. Grahn D. , 2002. Pathology effects at radiation doses below those causing increased mortality. Radiat. Res. 158, 187–194.

Carnes B.A. Grahn D. Hoel D.G. , 2003. Mortality of atomic bomb survivors predicted from laboratory animals. Radiat. Res. 160, 159–167.

Carney J.P. Maser R.S. Olivares H. , 1998. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 93, 477–486.

Caron J. , 2004. Biology and ‘the bomb’. Eng. Sci. 47, 16–27.

Carr Z.A. Kleinerman R.A. Weinstock R. Stovall M. Greim M.L. Land C.E. , 2002. Malignant neoplasms after radiation therapy for peptic ulcer. Radiat. Res. 157, 668–677.

Cattanach B.M. Patrick G. Papworth D. , 1995. Investigation of lung tumour induction in BALB/cJ mice following paternal X-irradiation. Int. J. Radiat. Biol. 67, 607–615.

Celeste A. Petersen S. Romanienko P.J. , 2002. Genomic instability in mice lacking histone H2AX. Science 296, 922–927.

Celeste A. Fernandez-Capetillo O. Kruhlak M.J. , 2003. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat. Cell Biol. 5, 675–679.

Cerosaletti K.M. Concannon P. , 2003. Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation. J. Biol. Chem. 278, 21944–21951.

Chang W.P. Little J.B. , 1991. Delayed reproductive death in X-irradiated Chinese hamster ovary cells. Int. J. Radiat. Biol. 60, 483–496.

Chang W.P. Little J.B. , 1992. Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving x-irradiation: association with delayed reproductive death phenotype. Mutat. Res. 270, 191–199.

CIRRPC, 1988. Science Panel Report No. 6. Use of Probability of Causation by the Veterans Administration in the Adjudication of Claims of Injury due to Exposure to Ionizing Radiation. ORAU 88/F-4. Committee on Interagency Radiation Research and Policy Coordination, Office of Science and Technology Policy, Executive Office of the President, Washington, DC.

Clifton K.H. Tanner M.A. Gould M.N. , 1986. Assessment of radiogenic cancer initiation frequency per clonogenic rat mammary cell in vivo. Cancer Res. 46, 2390–2395.

COMARE, 2002. Seventh Report. Parents Occupationally Exposed to Radiation Prior to the Conception of their Children. A Review of the Evidence Concerning the Incidence of Cancer in their Children. Committee on Medical Aspects of Radiation in the Environment, National Radiological Protection Board. Available from: http://www.comare.org.uk/.

COMARE, 2004. Eighth Report. Review of Pregnancy Outcomes Following Preconceptual Exposure to Radiation. Committee on Medical Aspects of Radiation in the Environment, National Radiological Protection Board. Available from: http://www.comare.org.uk/.

Cornforth M.N. , 1990. Testing the notion of the one-hit exchange. Radiat. Res. 121, 21–27.

Cornforth M.N. Bailey S.M. Goodwin E.H. , 2002. Dose responses for chromosome aberrations produced in noncycling primary human fibroblasts by alpha particles, and by gamma rays delivered at sublimiting low dose rates. Radiat. Res. 158, 43–53.

Cortez D. Guntuku S. Qin J. Elledge S.J. , 2001. ATR and ATRIP: partners in checkpoint signaling. Science 294, 1713–1716.

Cory S. Adams J.M. , 2002. The Bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2, 647–656.

Court Brown W.M. Doll R. , 1958. Expectation of life and mortality from cancer among British radiologists. Br Med J 2 (34), 181–187.

Cox R. Edwards A.A. , 2002. Comments on the paper: Microsatellite instability in acute myelocytic leukaemia developed from A-bomb survivors — and related cytogenic data. Int. J. Radiat. Biol. 78, 443–445.

Critchlow S.E. Bowater R.P. Jackson S.P. , 1997. Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr. Biol. 7, 588–598.

Dai Y. Kysela B. Hanakahi L.A. , 2003. Non-homologous end joining and V(D)J recombination require an additional factor. Proc. Natl. Acad. Sci. USA 100, 2462–2467.

Darroudi F. Natarajan A.T. , 1989. Cytogenetical characterization of Chinese hamster ovary X-ray-sensitive mutant cells xrs 5 and xrs 6. VII. Complementation analysis of X-irradiated wild-type CHO-K1 and xrs mutant cells using the premature chromosome condensation technique. Mutat. Res. 213, 249–255.

David-Cordonnier M.H. Laval J. O'Neill P. , 2000. Clustered DNA damage, influence on damage excision by XRS5 nuclear extracts and Escherichia coli Nth and Fpg proteins. J. Biol. Chem. 275, 11865–11873.

David-Cordonnier M.H. Laval J. O'Neill P. , 2001. Recognition and kinetics for excision of a base lesion within clustered DNA damage by the Escherichia coli proteins Fpg and Nth. Biochemistry 40, 5738–5746.

Davis F.G. Jr. Boice J.D. Kelsey J.L. Monson R.R. , 1987. Cancer mortality after multiple fluoroscopic examinations of the chest. J. Natl. Cancer Inst. 78, 645–652.

Deb S.P. , 2003. Cell cycle regulatory functions of the human oncoprotein MDM2. Mol. Cancer Res. 1, 1009–1016.

Delongchamp R.R. Mabuchi K. Yoshimoto Y. Preston D.L. , 1997. Cancer mortality among atomic bomb survivors exposed in utero or as young children, October 1950 — May 1992. Radiat. Res. 147, 385–395.

Deshpande A. Goodwin E.H. Bailey S.M. Marrone B. Lehnert B. , 1996. Alpha-particle-induced sister chromatid exchanges in normal human lung fibroblasts: evidence for an extranuclear target. Radiat. Res. 152, 552–557.

Desmaze C. Alberti C. Martins L. , 1999. The influence of interstitial telomeric sequences on chromosome instability in human cells. Cytogenet. Cell Genet. 86, 288–295.

Desmaze C. Soria J.C. Freulet-Marriere M.A. Mathieu N. Sabatier L. , 2003. Telomere-driven genomic instability in cancer cells. Cancer Lett. 194, 173–182.

Difilippantonio M.J. Zhu J. Chen H.T. , 2000. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature 404, 510–514.

Di Leonardo A. Linke S.P. Clarkin K. Wahl G.M. , 1994. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8, 2450–2551.

Ding Q. Reddy Y.V. Wang W. , 2003. Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Mol. Cell Biol. 23, 5836–5848.

Doll R. , 1995. Hazards of ionizing radiation: 100 years of observation on man. Br. J. Cancer 72, 1339–1349.

Doll R. , 1999. The Seascale cluster: a probable explanation. Br. J. Cancer 81, 3–5.

Doll R. Wakeford R. , 1997. Risk of childhood cancer from fetal irradiation. Br. J. Radiol. 79, 130–139.

Doll R. Evans H.J. Darby S.C. , 1994. Paternal exposure not to blame. Nature 367, 678–680.

Dolling J.A. Boreham D.R. Bahen M.E. Mitchel R.E. , 2000. Role of RAD9-dependent cell-cycle checkpoints in the adaptive response to ionizing radiation in yeast, Saccharomyces cerevisiae . Int. J. Radiat. Biol. 76, 1273–1279.

Domann F.E. Freitas M.A. Gould M.N. Clifton K.H. , 1994. Quantifying the frequency of radiogenic thyroid-cancer per clonogenic cell in-vivo. Radiat. Res. 137, 330–337.

Donehower L.A. Harvey M. Slagle B.L. , 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215–221.

Doody M.M. Lonstein J.E. Stovall M. Hacker D.G. Luckyanov N. Land, C.E. for the US Scoliosis Cohort Study Collaborators , 2000. Breast cancer mortality following diagnostic x rays: findings from the US Scoliosis Cohort Study. Spine 25, 2052–2063.

Dubrova Y.E. Plumb M. , 2002. Ionising radiation and mutation induction at mouse minisatellite loci. The story of the two generations. Mutat. Res. 499, 143–150.

Dubrova Y.E. Plumb M. Brown J. Jeffreys A.J. , 1998. Radiation-induced germline instability at minisatellite loci. Int. J. Radiat. Biol. 74, 689–696.

Ducray C. Pommier J.P. Martins L. Boussin F.D. Sabatier L. , 1999. Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process. Oncogene 18, 4211–4223.

Dugan L.C. Bedford J.S. , 2003. Are chromosomal instabilities induced by exposure of cultured normal human cells to low- or high-LET radiation?. Radiat. Res. 159, 301–311.

Durocher D. Jackson S.P. , 2001. DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?. Curr. Opin. Cell Biol. 13, 225–231.

EPA, 1999. Estimating Radiogenic Cancer Risks. EPA Report 402-R-00–003. Environmental Protection Agency, Washington, DC.

Ethier S.P. Ullrich R.L. , 1984. Factors influencing expression of mammary ductal dysplasia in cell dissociation-derived murine mammary outgrowths. Cancer Res. 44, 4523–4527.

Evans H.H. Horng M.F. Ricanati M. Diaz-Insua M. Jordan R. Schwartz J.L. , 2001. Diverse delayed effects in human lymphoblastoid cells surviving exposure to high-LET 56Fe particles or low-LET 137Cs gamma radiation. Radiat. Res. 156, 259–271.

Fearson E. Vogelstein B. , 1990. A genetic model for colorectal tumorigenesis. Cell 61, 759–767.

Fei P. El-Deiry W.S. , 2003. P53 and radiation responses. Oncogene 22, 5774–5783.

Feijoo C. Hall-Jackson C. Wu R. , 2001. Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing. J. Cell Biol. 154, 913–923.

Ferguson D.O. Sekiguchi J.M. Chang S. , 2000. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc. Natl. Acad. Sci. USA 97, 6630–6633.

Fernandez-Capetillo O. Chen H.T. Celeste A. , 2002. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat. Cell Biol. 4, 993–997.

Finkel M.P. Biskis B.O. , 1968. Experimental induction of osteosarcomas. Prog. Exp. Tumor Res. 10, 72–111.

Fodde R. Smits R. Clevers H. , 2001. APC, signal transduction and genetic instability in colorectal cancer. Nat. Rev. Cancer 1, 55–67.

Folkard M. Schettino G. Vojnovic B. , 2001. A focused ultrasoft x-ray microbeam for targeting cells individually with submicrometer accuracy. Radiat. Res. 156, 796–804.

Foray N. Marot D. Gabriel A. , 2003. A subset of ATM and ATR-dependent phosphorylation events requires the BRCA1 protein. EMBO J. 22, 2860–2871.

Foulds S.L. , 1975. Neoplastic Development. Academic Press, New York, NY.

Frank K.M. Sekiguchi J.M. Seidl K.J. , 1998. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature 396, 173–177.

Frank-Vaillant M. Marcand S. , 2001. NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the Ligase IV pathway. Genes Dev. 15, 3005–3012.

Fry R.J.M. , 1992. The role of animal experiments in estimates of radiation risks. In: Lett J.T. Sinclair W.K. (Eds.), Advances in Radiation Research. Academic Press, New York, NY, pp. 181–197.

Fry S.A. , 1998. Studies of US radium dial workers: an epidemiological classic. Radiat. Res. 150, S21–S29.

Fry R.J.M. Storer J.B. , 1987. External radiation carcinogenesis. Adv. Radiat. Biol. 13, 31.

Fry R.J.M. Ainsworth E.J. Williamson F.S. , 1977. Age-dependency of radiation-induced late effects. Radiat. Res. 70, 609.

Fugmann S.D. Lee A.I. Shockett P.E. Villey I.J. Schatz D.G. , 2000. The RAG proteins and V(D)J recombination: complexes, ends, and transposition. Annu. Rev. Immunol. 18, 495–527.

Fukushima T. Takata M. Morrison C. , 2001. Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S-G2 phase DNA double-strand break repair. J. Biol. Chem. 276, 44413–44418.

Furuya K. Carr A.M. , 2003. DNA checkpoints in fission yeast. J. Cell Sci. 116, 3847–3848.

Gardner M.J. Snee M.P. Hall A.J. Powell C.A. Downes S. Terrell J.D. , 1990. Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. BMJ 300, 423–429.

Gellert M. , 2002. V(D)J recombination: RAG proteins, repair factors, and regulation. Annu. Rev. Biochem. 71, 101–132.

Gilbert E.S. , 2002. The risk of cancer from exposure to plutonium. Radiat. Res. 158, 783–784.

Gilbert R.O. Mart E.I. Denham D.H. Strenge D.L. Miley T.B. , 1996. Uncertainty of historical measurements of 1311 in Hanford-area vegetation. Health Phys. 70, 160–170.

Girard P.-M. Riballo E. Begg A. Waugh A. Jeggo P.A. , 2002. Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest. Oncogene 21, 4191–4199.

Goldberg M. Stucki M. Falck J. , 2003. MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature 421, 952–956.

Goodarzi A.A. Block W.D. Lees-Miller S.P. , 2003. The role of ATM and ATR in DNA damage-induced cell cycle control. Prog. Cell Cycle Res. 5, 393–411.

Goodhead D.T. , 1994. Initial events in the cellular effects of ionising radiations: clustered damage in DNA. Int. J. Radiat. Biol. 65, 7–17.

Gould M.N. Watanabe H. Kamiya K. Clifton K.H. , 1987. Modification of expression of the malignant phenotype in radiation-initiated cells. J. Radiat. Biol. 51, 1081–1090.

Goyette M.C. Cho K. Fasching C.L. , 1992. Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer. Mol. Cell Biol. 12, 1387–1395.

Grahn D. Hamilton K.F. , 1964. Influence of sex, environment + radiation factors on life shortening + tumor incidence in C3Hf mice. Radiat. Res. 22, 191.

Grahn D. Sacher G.A. , 1957. Chronic radiation mortality in mice after single whole-body exposure to 250-Kvp, 135-Kvp, and 80-Kvp x-rays. Radiat. Res. 7, 319.

Grahn D. Sacher G.A. , 1958. Chronic radiation mortality in mice after single whole-body exposure to 250-Kvp, 135-Kvp, and 80-Kvp x-rays. Radiat. Res. 8, 187–194.

Grahn D. Sacher G.A. Hamilton K.F. , 1963. A uniformity of life-shortening among genetically different mice under daily gamma radiation. Radiat. Res. 19, 239.

Grawunder U. Wilm M. Wu X. , 1997. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature 388, 492–495.

Grawunder U. Zimmer D. Lieber M.R. , 1998. DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains. Curr. Biol. 8, 873–876.

Griem M.L. Kleinerman R.A. Boice J.D. Jr. Stovall M. Shefner D. Lubin J.H. , 1994. Cancer following radiotherapy for peptic ulcer. J. Natl. Cancer Inst. 86, 842–849.

Griffin C.S. Stevens D.L. Savage J.R.K. , 1996. Ultrasoft 1.5 keV aluminum K x rays are efficient producers of complex chromosome exchange aberrations as revealed by fluorescence in situ hybridization. Radiat. Res. 146, 144–150.

Grogan H.A. Sinclair W.K. Voilleque P.G. , 2001. Risks of fatal cancer from inhalation of 239,240 plutonium by humans: a combined four-method approach with uncertainty evaluation. Health Phys. 80, 447–461, Erratum in: Health Phys. 2002; 82, 404.

Grosovsky A.J. de Boer G. De Jong P.J. Drobetsky E.A. Glickman B.W. , 1988. Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutations in mammalian cells. Proc. Natl. Acad. Sci. USA 85, 185–188.

Grosovsky A.J. Parks K.K. Giver C.R. Nelson S.L. , 1996. Clonal analysis of delayed karyotypic abnormalities and gene mutations in radiation-induced genetic instability. Mol. Cell. Biol. 16, 6252–6262.

Gu Y.S. Seidl K.J. Rathbun G.A. , 1997. Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity 7, 653–665.

Gulston M. de Lara C. Jenner T. Davis E. O'Neill P. , 2004. Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation. Nucleic Acids Res. 32, 1602–1609.

Haenszel W. Kurihara M. , 1968. Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States. J. Natl. Cancer Inst. 40, 43–68.

Haines J. Dunford R. Moody J. Ellender M. Cox R. Silver A. , 2000. Loss of heterozygosity in spontaneous and X-ray-induced intestinal tumors arising in FI hybrid Min mice: evidence for sequential loss of Apc(+) and Dpc4 in tumor development. Genes Chromosom. Cancer 28, 387–394.

Hallahan D.E. Sukhatme V.P. Sherman M.L. Virudachalam S. Kufe D. Weichselbaum R.R. , 1991. Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGRI and JUN. Proc. Natl. Acad. Sci. USA 87, 5663–5666.

Hanahan D. Weinberg R.A. , 2000. The hallmarks of cancer. Cell 100, 57–70.

Hanson W.R. Fry R.J.M. Sallese A.R. Frischer H. Ahmad T. Ainsworth E.J. , 1987. Comparison of intestine and bone-marrow radiosensitivity of the Balb/C and the C57B1/6 mouse strains and their B6Cf1 offspring. Radiat. Res. 110, 340–352.

Hartley K.O. Gell D. Smith G.C.M. , 1995. DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82, 849–856.

Harvey E.B. Boice J.D. Jr. Honeyman M. Flannery J.T. , 1985. Prenatal x-ray exposure and childhood cancer in twins. N. Engl. J. Med. 312, 541–545.

Hei T.K. Wu L-J. Liu S-X. Vannais D. Waldren C.A. Randers-Pehrson G. , 1997. Mutagenic effects of a single and an exact number of α particles in mammalian cells. Proc. Natl. Acad. Sci. USA 94, 3765–3770.

Helleday T. , 2003. Pathways for mitotic homologous recombination in mammalian cells. Mutat. Res. 532, 103–115.

Hendry J.H. Potten C.S. Chadwick C. Bianchi M. , 1982. Cell death (apoptosis) in the mouse small intestine after low doses: effects of dose-rate, 14.7 MeV neutrons, and 600 MeV (maximum energy) neutrons. Int. J. Radiat. Biol. 42, 611–620.

Hesslein D.G. Schatz D.G. , 2001. Factors and forces controlling V(D)J recombination. Adv. Immunol. 78, 169–232.

Hoel D.G. Li P. , 1998. Threshold models in radiation carcinogenesis. Health Phys. 75, 241–250.

Holmberg K. Fair S. Johansson A. Lambert B. , 1993. Clonal chromosome aberrations and genomic instability in x-irradiated human T-lymphocyte cultures. Mutat. Res. 286, 321–330.

Hoshino H. Tanooka H. , 1975. Interval effect of beta-irradiation and subsequent 4-nitroquinoline 1-oxide painting on skin tumor induction in mice. Cancer Res. 35, 3663–3666.

Howe G.R. , 1995. Lung cancer mortality between 1950 and 1987 after exposure to fractionated moderate-dose-rate ionizing radiation in the Canadian fluoroscopy cohort study and a comparison with lung cancer mortality in the atomic bomb survivors study. Radiat. Res. 142, 295–304.

Howe G.R. McLaughlin J. , 1996. Breast cancer mortality between 1950 and 1987 after exposure to fractionated moderate-dose-rate ionizing radiation in the Canadian fluoroscopy cohort study and a comparison with breast cancer mortality in the atomic bomb survivors study. Radiat. Res. 145, 694–707.

Howell R.W. Bishayee A. , 2002. Bystander effects caused by nonuniform distributions of DNA-incorporated (125)I. Micron 33, 127–132.

Howlett N.G. Taniguchi T. Olson S. , 2002. Biallelic inactivation of BRCA2 in Fanconi anemia. Science 297, 606–609.

Hulse E.V. Mole R.H. , 1969. Skin tumour incidence in Cba mice given fractionated exposures to low energy beta particles. Br. J. Cancer 23, 452–463.

Huo L. Nagasawa H. Little J.B. , 2001. HPRT mutants induced in bystander cells by very low fluences of alpha particles result primarily from point mutations. Radiat. Res. 156, 521–525.

IAEA, 1989. Safety Series 100. Evaluating the Reliability of Predictions Made Using Environmental Transfer Models. International Atomic Energy Agency, Vienna.

IARC, 2000. Monographs on the Evaluation of Carcinogenic Risks to Humans. Vol. 75, Ionizing Radiation, Part 1: X- and Gamma Radiation and Neutrons. IARC, Lyon.

IARC, 2001. Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 78. Ionizing Radiation, Part 2: Some Internally Deposited Radionuclides. IARC Press, Lyon, France.

ICRP, 1991. 1990 Recommendations of the International Commission on Radiological Protection. ICRP Publication 60, Ann. ICRP 21 (1–3).

ICRP, 2003. Biological effects after prenatal irradiation (embryo and fetus), ICRP Publication 90. Ann. ICRP 33 (1/2).

ICRP, 2003. Biological effects after prenatal irradiation (embryo and fetus). ICRP Publication 90, Ann. ICRP 21 (1/2).

ICRP, 2006. Human alimentary tract model for radiological protection. ICRP Publication 100, Ann. ICRP 36 (1/2).

Ikushima T. Aritomi H. Morisita J. , 1996. Radioadaptive response: efficient repair of radiation-induced DNA damage in adapted cells. Mutat. Res. 358, 193–198.

Iliakis G. Wang Y. Guan J. Wang H. , 2003. DNA damage checkpoint control in cells exposed to ionizing radiation. Oncogene 22, 5834–5847.

Inskip P.D. Monson R.R. Wagoner J.K. , 1990. Cancer mortality following radium treatment for uterine bleeding. Radiat. Res. 123, 331–344.

Ishii K. Watanabe M. , 1996. Participation of gap-junctional cell communication on the adaptive response in human cells induced by low dose of x-rays. Int. J. Radiat. Biol. 69, 291–299.

Ishii K. Hosoi Y. Yamada S. Ono T. Sakamoto K. , 1996. Decreased incidence of thymic lymphoma in AKR mice as a result of chronic, fractionated low-dose total-body X irradiation. Radiat. Res. 146, 582–585.

International Nijmegen Breakage Syndrome Study Group, 2000. Nijmegen breakage syndrome. The International Nijmegen Breakage Syndrome Study Group. Arch. Dis. Child 82, 400–406.

Iyer R. Lehnert B.E. , 2002. Alpha-particle-induced increases in the radioresistance of normal human bystander cells. Radiat. Res. 157, 3–7.

Izumi S. Koyama K. Soda M. Suyama A. , 2003. Cancer incidence in children and young adults did not increase relative to parental exposure to atomic bombs. Br. J. Cancer 89, 1709–1713.

Jackson S. , 2002. Sensing and repairing DNA double strand breaks. Carcinogenesis 23, 687–696.

Jaffe D. Bowden G.T. , 1987. Ionizing radiation as an initiator — effects of proliferation and promotion time on tumor-incidence in mice. Cancer Res. 47, 6692–6696.

Jamali M. Trott K.R. , 1996. Persistent increase in the rates of apoptosis and dicentric chromosomes in surviving V79 cells after X-irradiation. Int. J. Radiat. Biol. 70, 705–709.

Jeggo P.A. , 1998. DNA breakage and repair. Adv. Genet. 38, 185–211.

Jeggo P.A. Concannon P. , 2001. Immune diversity and genomic stability: opposite goals but similar paths. J. Photochem. Photobiol. B 65, 88–96.

Jeggo P.A. O'Neill P. , 2002. The Greek goddess, Artemis, reveals the secrets of her cleavage. DNA Rep. 67, 1–7.

Jimenez G.S. Bryntesson F. Torres-Arzayus M.I. , 1999. DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage. Nature 400, 81–83.

Johzuka K. Ogawa H. , 1995. Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae . Genetics 139, 1521–1532.

Joiner M-C. Lambin P. Malaise E.P. , 1996. Hypersensitivity to very-low single radiation doses: its relationship to radioadaptive response and induced resistance. Mutat. Res. 358, 171–183.

Joiner M.C. Marples B. Lambin P. Short S.C. Turesson I. , 2001. Low-dose hypersensitivity: current status and possible mechanisms. Int. J. Radiat. Oncol. Biol. Phys. 49, 379–389.

Kadhim M.A. MacDonald D.A. Goodhead D.T. Lorimore S.A. Marsden S.J. Wright E.G. , 1992. Transmission of chromosomal aberrations and genomic instability after plutonium alpha particle irradiation. Nature 355, 738–740.

Kadhim M.A. Lorimore S.A. Townsend K.M. Goodhead D.T. Buckle V.J. Wright E.G. , 1995. Radiation-induced genomic instability: delayed cytogenetic aberrations and apoptosis in primary human bone marrow cells. Int. J. Radiat. Biol. 67, 287–293.

Kadhim M.A. Marsden S.J. Wright E.G. , 1998. Radiation-induced chromosomal instability in human fibroblasts: temporal effects and the influence of radiation quality. Int. J. Radiat. Biol. 73, 143–148.

Kadhim M.A. Marsden S.J. Goodhead D.T. , 2001. Long-term genomic instability in human lymphocytes induced by single-particle irradiation. Radiat. Res. 155, 122–126.

Kadim M.A. Macdonald D.A. Goodhead D.T. Lorimore S.A. Marsden S.J. Wright E.G. , 1991. Transmission of chromosomal instability after plutonium α -particle irradiation. Nature 355, 738–740.

Kanaar R. Hoeijmakers J.H. van Gent D.C. , 1998. Molecular mechanisms of DNA double strand break repair. Trends Cell Biol. 8, 483–489.

Kang C-M. Park K-P. Cho C-K. , 2002. Hspa4 (HSP70) is involved in the radioadaptive response: results from mouse splenocytes. Radiat. Res. 157, 650–655.

Kaplan H.S. , 1964. The role of radiation in experimental leukemogenesis. Natl. Cancer Inst. Monog. 14, 207–220.

Kaplan H.S. , 1967. On the natural history of murine leukemias. Cancer Res. 27, 1325–1340.

Karanjawala Z.E. Grawunder U. Hsieh C.L. Lieber M.R. , 1999. The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts. Curr. Biol. 9, 1501–1504.

Kastan M.B. Onyekewere O. Sidransky D. Vogelstein B. Craig R.W. , 1991. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51, 6304–6311.

Kastan M.B. Zhan Q. El-Deiry W.S. , 1992. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71, 587–597.

Kegel A. Sjostrand J.O. Astrom S.U. , 2001. Nej1p, a cell type-specific regulator of nonhomologous end joining in yeast. Curr. Biol. 11, 1611–1617.

Kellerer A.M. , 1985. Fundamentals of microdosimetry. In: Kase K.R. Bjarngard B.E. Attix F.H. (Eds.), The Dosimetry of Ionizing Radiation. Academic Press, New York, NY, pp. 77–162.

Kelsey K.T. Memisoglu A. Frenkel D. Liber H. , 1991. Human lymphocytes exposed to low doses of X-rays are less susceptible to radiation-induced mutagenesis. Mutat. Res. 263, 197–201.

Kemp L.M. Jeggo P.A. , 1986. Radiation-induced chromosome damage in X-ray-sensitive mutants (xrs) of the Chinese hamster ovary cell line. Mutat. Res. 166, 255–263.

Kemp C.J. Wheldon T. Balmain A. , 1994. P53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nat. Genet. 8, 66–69.

Kennedy A.R. Little J.B. , 1984. Evidence that a second event in x-ray induced oncogenic transformation in vitro occurs during cellular proliferation. Radiat. Res. 99, 228–248.

Kennedy A.R. Fox M. Murphy G. Little J.B. , 1980. Relationship between x-ray exposure and malignant transformation in C3H 10T1/2 cells. Proc. Natl. Acad. Sci. USA 77, 7262–7266.

Kennedy A.R. Cairns J. Little J.B. , 1984. Timing of the steps in transformation of C3H 10T1/2 cells by x-irradiation. Nature 307, 85–86.

Khanna K.K. Keating K.E. Kozlov S. , 1998. ATM associates with and phosphorylates p53: mapping the region of interaction. Nat. Genet. 20, 398–400.

Khokhrykov V. Suslova K. Aladova E. , 2000. Development of an improved dosimetry system for the workers at the Mayak Production Association. Health Phys. 79, 72–76.

Kim S.T. Xu B. Kastan M.B. , 2002. Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev. 16, 560–570.

Knudson A. , 2001. Two genetic hits (more or less) to cancer. Nat. Rev. Cancer 1, 157–162.

Ko L.J. Prives C. , 1996. p53: puzzle and paradigm. Genes Dev. 10, 1054–1072.

Kobayashi J. Tauchi H. Sakamoto S. , 2002. NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain. Curr. Biol. 12, 1846–1851.

Kocher D.C. Apostoaei A.I. Hoffman F.O. , 2002. Radiation Effectiveness Factors (REFs) for Use in Calculating Probability of Causation of Radiogenic Cancers. Draft report submitted by SENES Oak Ridge, Inc., Oak Ridge, TN to the National Institute of Occupational Safety and Health. Available at: http://www.cdc.gov/niosh/ocas/pdfs/irepref.pdf.

Kopecky K.J. Nakashima E. Yamamoto T. Kato H. , 1986. Lung Cancer, Radiation, and Smoking Among A-bomb Survivors, Hiroshima and Nagasaki. TR 13–86. Radiation Effects Research Foundation, Hiroshima and Nagasaki.

Kubbutat M.H. Ludwig R.L. Ashcroft M. Vousden K.H. , 1998. Regulation of Mdm2-directed degradation by the C terminus of p53. Mol. Cell Biol. 18, 5690–5698.

Kuhne M. Rothkamm K. Lobrich M. , 2002. Physical and biological parameters affecting DNA double strand break misrejoining in mammalian cells. Radiat. Prot. Dosim. 99, 129–132.

Kysela B. Doherty A.J. Chovanec M. , 2003. Ku stimulation of DNA ligase IV-dependent ligation requires inward movement along the DNA molecule. J. Biol. Chem. 278, 22466–22474.

Lakin N.D. Jackson S.P. , 1999. Regulation of p53 in response to DNA damage. Oncogene 18, 7644–7655.

Land C.E. , 1980. Cancer risks from low doses of ionizing radiation. Science 209, 1197–1203.

Land C. , 2002. Uncertainty, low-dose extrapolation and the threshold hypothesis. J. Radiol. Prot. 22, A129–A135.

Land C.E. Boice J.D. Jr. Shore R.E. Norman J.E. Tokunaga M. , 1980. Breast cancer risk from low-dose exposures to ionizing radiation: results of parallel analysis of three exposed populations of women. J. Natl. Cancer Inst. 65, 353–376.

Land C.E. Hayakawa N. Machado S. , 1994. A case-control interview study of breast cancer among Japanese A-bomb survivors. II. Interactions between epidemiological factors and radiation dose. Cancer Causes Control 5, 167–176.

Land C.E. Tokunaga M. Koyama K. , 2003. Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950–1990. Radiat. Res. 160, 707–717.

Latre L. Tusell L. Martin M. , 2003. Shortened telomeres join to DNA breaks interfering with their correct repair. Exp. Cell Res. 287, 282–288.

Lee J.M. Bernstein A. , 1993. p53 mutations increase resistance to ionizing radiation. Proc. Natl. Acad. Sci. USA 90, 5742–5746.

Lee J.S. Collins K.M. Brown A.L. Lee C.H. Chung J.H. , 2000. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 404, 201–204.

Lee Y-J. Park G-H Cho H-N. , 2002. Induction of adaptive response by low-dose radiation in RIF cells transfected with Hspb1 (Hsp25) or inducible Hspa (Hsp70). Radiat. Res. 157, 371–377.

Lees-Miller S.P. Meek K. , 2003. Repair of DNA double strand breaks by non-homologous end joining. Biochimie 85, 1161–1173.

Le X.C. Xing J.Z. Lee J. Leadon S.A. Weinfeld M. , 1998. Inducible repair of thymine glycol detected by an ultrasensitive assay for DNA damage. Science 280, 1066–1069.

Lehnert B. Goodwin E.H. , 1997. Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells. Cancer Res. 57, 2164–2171, Erratum in: Cancer Res. (2003) 63, 1439.

Lesher S. Hamilton K. Grahn D. Sacher G. , 1960. The causes of death for Laf1 mice exposed to low dose, daily, Co-60 gamma-irradiation. Radiat. Res. 12, 451.

Lesher S. Sacher G.A. Grahn D. Hamilton K. Sallese A. , 1965. Survival of mice under duration-of-life exposure to gamma rays. 2. Pathologic effects. Radiat. Res. 24, 239–277.

Leskov K.S. Criswell T. Antonio S. , 2001. When x-ray-inducible proteins meet DNA double strand break repair. Semin. Radiat. Oncol. 11, 352–372.

Lewis E.B. , 1957. Leukemia and ionizing radiation. Science 125, 965–972.

Lewis E.B. , 1963. Leukemia, multiple myeloma, and aplastic anemia in American radiologists. Science 142, 1492–1494.

Lewis D.A. Mayhugh B.M. Qin Y. Trott K. Mendonca M.S. , 2001. Production of delayed death and neoplastic transformation in CGL1 cells by radiation-induced bystander effects. Radiat. Res. 156, 251–258.

Lieber M.R. Ma Y. Pannicke U. Schwarz K. , 2003. Mechanism and regulation of human nonhomologous DNA end-joining. Nat. Rev. Mol. Cell Biol. 4, 712–720.

Li C-Y. Yandell D.W. Little J.B. , 1992. Evidence for coincident mutations in human lymphoblast clones selected for functional loss of a thymidine kinase gene. Mol. Carcinogen 5, 270–277.

Li Z. Otevrel T. Gao Y. , 1995. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell 83, 1079–1089.

Limoli C.L. Hartmann A. Shepard L. , 1998. Apoptosis, reproductive failure and oxidative stress in Chinese hamster ovary cells with compromised genomic integrity. Cancer Res. 58, 3712–3718.

Limoli C.L. Corcoran J.J. Milligan J.R. Ward J.F. Morgan W.F. , 1999. Critical target and dose and dose-rate responses for the induction of chromosomal instability by ionizing radiation. Radiat. Res. 151, 677–685.

Limoli C.L. Ponnaiya B. Corcoran J. J. , 2000. Genomic instability by high and low LET ionizing radiation. Adv. Space Res. 25, 2107–2117.

Limoli C.L. Kaplan M.I. Giedzinski E. Morgan W.F. , 2001. Attenuation of radiation-induced genomic instability by free radical scavengers and cellular proliferation. Free Radic. Biol. Med. 31, 10–19.

Lindahl T. Sedgwick B. Sekiguchi M. Nakabeppu Y. , 1988. Regulation and expression of the adaptive response to alkylating agents. Ann. Rev. Biochem. 57, 133–157.

Lindberg S. Karlsson P. Arvidsson B. Holmberg E. Lunberg L.M. Wallgren A. , 1995. Cancer incidence after radiotherapy for skin haemangioma during infancy. Acta Oncol. 34, 735–740.

Little J.B. , 1968. Delayed initiation of DNA synthesis in irradiated human diploid cells. Nature 146, 1064–1065.

Little J.B. , 1998. Radiation-induced genomic instability. Int. J. Radiat. Biol. 6, 663–671.

Little M.P. , 2002. Comments on the paper: Microsatellite instability in acute myelocytic leukaemia developed from A-bomb survivors. Int. J. Radiat. Biol. 78, 441–443.

Little J.B. , 2003. Genomic instability and bystander effects: a historical perspective. Oncogene 22, 6978–6987.

Little M.P. Boice J.D. Jr. , 1999. Comparison of breast cancer incidence in the Massachusetts tuberculosis fluoroscopy cohort and in the Japanese atomic bomb survivors. Radiat. Res. 151, 218–224.

Little M.P. Muirhead C.R. , 2000. Derivation of low dose extrapolation factors from analysis of curvature in the cancer incidence dose response in Japanese atomic bomb survivors. Int. J. Radiat. Biol. 76, 939–953.

Little J.B. Gorgojo L. Vetrovs H. , 1990. Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells. Int. J. Radiat. Oncol. Biol. Phys. 19, 1425–1429.

Little J.B. Nagasawa H. Pfenning T. Vetrovs H. , 1997. Radiation-induced genomic instability: delayed mutagenic and cytogenetic effects of X-rays and alpha particles. Radiat. Res. 148, 299–307.

Little J.B. Nagasawa H. Li G.C. Chen D.J. , 2003. Involvement of the nonhomologous end joining DNA repair pathway in the bystander effect for chromosomal aberrations. Radiat. Res. 159, 262–267.

Little M.P. Cox R. Edwards A.A. , 2003. Comments on the paper: Microsatellite instability in acute myelocytic leukaemia developed from A-bomb survivors. Reply to Plumb. Int. J. Radiat. Biol. 79, 371–374.

Liu Y. Masson J.Y. Shah R. O'Regan P. West S.C. , 2004. RAD51C is required for Holliday junction processing in mammalian cells. Science 303, 243–246.

Lloyd D.C. Edwards A.A. Leonard A. , 1992. Chromosomal aberrations in human lymphocytes induced in vitro by very low doses of X-rays. Int. J. Radiat. Biol. 61, 335–343.

Löbrich M. Rief N. Kuhne M. , 2005. In vivo formation and repair of DNA double-strand breaks after computed tomography examinations. Proc. Natl. Acad. Sci. USA 102, 8984–8989.

Loeb L.A. , 1991. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 51, 3075–3079.

Loeb L.A. , 2001. A mutator phenotype in cancer. Cancer Res. 61, 3230–3239.

Loeb L.A. Loeb K.R. Anderson J.P. , 2003. Multiple mutations and cancer. Proc. Natl. Acad. Sci. USA 100, 776–781.

Lo A.W. Sprung C.N. Fouladi B. , 2002a. Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells. Mol. Cell. Biol. 22, 4836–4850.

Lo A.W. Sabatier L. Fouladi B. Pottier L. Ricoul M. Murnane J.P. , 2002b. DNA amplification by breakage/fusion/bridge cycles initiated by spontaneous telomere loss in a human cancer cell line. Neoplasia 4, 531–538.

Lohrer H.D. Braselmann H. Richter H.E. , 2001. Instability of microsatellites in radiation-associated thyroid tumours with short latency periods. Int. J. Radiat. Biol. 77, 891–899.

Lord B.I. Woolford L.B. Want L. , 1998. Tumour induction by methyl-nitroso-urea following preconceptional paternal contamination with plutonium-239. Br. J. Cancer 78, 301–311.

Lorimore S.A. Wright E.G. , 2003. Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review. Int. J. Radiat. Biol. 79, 15–25.

Lorimore S. Kadhim M. Pocock D. , 1998. Chromosomal instability in the descendants of unirradiated surviving cells after α-particle irradiation. Proc. Natl. Acad. Sci. USA 95, 5730–5733.

Lorimore S.A. Coates P.J. Scobie G.E. Milne G. Wright E.G. , 2001. Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects? Oncogene 20, 7085–7095.

Lou Z. Chini C.C. Minter-Dykhouse K. Chen J. , 2003. MDC1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. J. Biol. Chem. 278, 13599–13602.

Lu X. Lane D.P. , 1993. Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?. Cell 75, 765–778.

Lubin J.H. Steindorf K. , 1995. Cigarette use and the estimation of lung cancer attributable to radon in the United States. Radiat. Res. 141, 79–85.

Lundell M. Hakulinen T. Holm L.E. , 1994. Thyroid cancer after radiotherapy for skin hemangioma in infancy. Radiat. Res. 140, 334–339.

Lyng F.M. Seymour C.B. Mothersill C. , 2001. Oxidative stress in cells exposed to low levels of ionizing radiation. Biochem. Soc. Trans. 29, 350–353.

Lyng F.M. Seymour C.B. Mothersill C. , 2002. Initiation of apoptosis in cells exposed to medium from the progeny of irradiated cells: a possible mechanism for bystander-induced genomic instability?. Radiat. Res. 157, 365–370.

Macdonald D. Boulton E. Pocock D. Goodhead D. Kadhim M. Plumb M. , 2001. Evidence of genetic instability in 3 Gy X-ray-induced mouse leukaemias and 3 Gy X-irradiation haemopoietic stem cells. Int. J. Radiat. Biol. 77, 1023–1031.

MacMahon B. , 1962. Prenatal X-ray exposure and childhood cancer. J. Natl. Cancer Inst. 28, 1173–1191.

Ma Y. Pannicke U. Schwarz K. Lieber M.R. , 2002. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 108, 781–794.

Malkin D. Li F.P. Strong L.C. , 1990. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250, 1233–1238.

Manke I.A. Lowery D.M. Nguyen A. Yaffe M.B. , 2003. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science 302, 636–639.

Marder B.A. Morgan W.F. , 1993. Delayed chromosomal instability induced by DNA damage. Mol. Cell Biol. 13, 6667–6677.

Marples B. Joiner M.C. , 2000. Modification of survival by DNA repair modifiers: a probable explanation for the phenomenon of increased radioresistance. Int. J. Radiat. Biol. 76, 305–312.

Matanoski G.M. Seltser R. Sartwell P.E. Diamond E.L. Elliott E. A. , 1975. The current mortality rates of radiologists and other physician specialists: specific causes of death. Am. J. Epidemiol. 101, 199–210.

Matasumoto H. Hayashi S. Hatashita M. , 2001. Induction of radioresistance by a nitric oxide-mediated bystander effect. Radiat. Res. 155, 387–396.

McCarthy E.E. Celebi J.T. Baer R. Ludwig T. , 2003. Loss of Bard1, the heterodimeric partner of the Brca1 tumour suppressor, results in early embryonic lethality and chromosomal instability. Mol. Cell Biol. 23, 5056–5063.

McIlrath J. Lorimore S.A. Coates P.J. Wright E.G. , 2003. Radiation-induced genomic instability in immortalized haemopoietic stem cells. Int. J. Radiat. Biol. 79, 27–34.

Meek D.W. Knippschild U. , 2003. Posttranslational modification of MDM2. Mol. Cancer Res. 1, 1017–1026.

Merkle D. Douglas P. Moorhead G.B. , 2002. The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation. Biochemistry 41, 12706–12714.

Merritt A.J. Potten C.S. Watson A.J. , 1995. Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia. J. Cell Sci. 108, 2261–2271.

Metting N.F. Koehler A.M. Nagasawa H. Nelson J.M. Little J.B. , 1995. Design of a benchtop alpha particle irradiator. Health Phys. 68, 710–715.

Mettler F.A. Jr. Upton A.C. , 1995. Medical Effects of Ionizing Radiation, 2nd ed. Saunders, Philadelphia, PA.

Miki Y. Swensen J. Shattuck-Eidens D. , 1994. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66–71.

Mills K.D. Ferguson D.O. Alt F.W. , 2003. The role of DNA breaks in genomic instability and tumorigenesis. Immunol. Rev. 194, 77–95.

Mitchel R.E. Jackson J.S. McCann R.A. Boreham D.R. , 1999. The adaptive response modifies latency for radiation-induced myeloid leukemia in CBA/H mice. Radiat. Res. 152, 273–279.

Mitchel R.E. Jackson J.S. Morrison D.P. Carlisle S.M. , 2003. Low doses of radiation increase the latency of spontaneous lymphomas and spinal osteosarcomas in cancer-prone, radiation-sensitive Trp53 heterozygous mice. Radiat. Res. 159, 320–327.

Mochan T.A. Venere M. DiTullio R.A. Jr. Halazonetis T.D. , 2003. 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Res. 63, 8586–8591.

Mohan A.K. Hauptmann M. Linet M.S. , 2002. Breast cancer mortality among female radiologic technologists in the United States. J. Natl. Cancer Inst. 94, 943–948.

Mohan A.K. Hauptmann M. Freedman D.M. , 2003. Cancer and other causes of mortality among radiologic technologists in the United States. Int. J. Cancer 103, 259–267.

Mole R.H. Major I.R. , 1983. Myeloid-leukemia frequency after protracted exposure to ionizing-radiation — experimental confirmation of the flat dose-response found in ankylosing-spondylitis after a single treatment course with x-rays. Leukem. Res. 7, 295–300.

Mole R.H. Papworth D.G. Corp M.J. , 1983. The dose-response for x-ray induction of myeloid-leukemia in male Cba/H mice. Br. J. Cancer 47, 285–291.

Momand J. Zambetti G.P. Olson D.C. George D. Levine A.J. , 1992. The mdm2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69, 1237–1245.

Monson R.R. MacMahon B. , 1984. Prenatal x-ray exposure and cancer in children. In: Boice J.D. Jr. Fraumeni J.F. Jr. (Eds.), Radiation Carcinogenesis: Epidemiology and Biological Significance. Raven Press, New York NY, pp. 97–105.

Morgan W.F. , 2003a. Review. Non-targeted and delayed effects of exposure to ionizing radiation. I. Radiation-induced genomic instability and bystander effects in vitro. Radiat. Res. 159, 567–580.

Morgan W.F. , 2003b. Review. Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation?. Oncogene 22, 7094–7099.

Morgan W.F. Day J.P. Kaplan M.I. McGhee E.M. Limoli C.L. , 1996. Genomic instability induced by ionizing radiation. Radiat. Res. 146, 247–258.

Mori N. Matsumoto Y. Okumoto M. Suzuki N. Yamate J. , 2001. Variations in Prkdc encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and susceptibility to radiation-induced apoptosis and lymphomagenesis. Oncogene 20, 3609–3619.

Morris T. Thacker J. , 1993. Formation of large deletions by illegitimate recombination in the HPRT gene of primary human fibroblasts. Proc. Natl. Acad. Sci. USA 90, 1392–1396.

Morris T. Thacker J. , 1993. Analysis of large deletions in the HPRT gene of primary human fibroblasts using the polymerase chain reaction. Proc. Natl. Acad. Sci. USA 90, 1392–1396.

Morris T. Masson W. Singleton B. Thacker J. , 1993. Somat. Cell Molec. Genet. 19, 9–19.

Moshous D. Callebaut I. de Chasseval R. , 2001. Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell 105, 177–186.

Mothersill C. Seymour C. , 1997. Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival or unirradiated cells. Int. J. Radiat. Biol. 71, 421–427.

Mothersill C. Seymour C.B. , 1998. Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal kidney keratinocytes: evidence for release during irradiation of a signal controlling survival into the medium. Radiat. Res. 149, 252–262.

Mothersill C. Seymour C. , 2001. Radiation-induced bystander effects: past history and future directions. Radiat. Res. 155, 759–767.

Mothersill C. Seymour C.B. Joiner M.C. , 2002. Relationship between radiation-induced low-dose hypersensitivity and the bystander effect. Radiat. Res. 157, 526–532.

Moynahan M.E. Chiu J.W. Koller B.H. Jasin M. , 1999. Brca1 controls homology-directed DNA repair. Mol. Cell 4, 511–518.

Moynahan M.E. Pierce A.J. Jasin M. , 2001. BRCA2 is required for homology-directed repair of chromosomal breaks. Mol. Cell 7, 263–272.

Muirhead C.R. Goodill A.A. Haylock R.G.E. , 1999. Occupational radiation exposure and mortality: second analysis of the National Registry for Radiation Workers. J. Radiol. Prot. 19, 3–26.

Mulcahy R.T. Gould M.N. Clifton K.H. , 1984. Radiogenic initiation of thyroid-cancer — a common cellular event. Int. J. Radiat. Biol. 45, 419–426.

Nagar S. Smith L.E. Morgan W.F. , 2003. Characterization of a novel epigenetic effect of ionizing radiation: the death-inducing effect. Cancer Res. 63, 324–328.

Nagasawa H. Little J.B. , 1992. Induction of sister chromatid exchanges by extremely low doses of alpha particles. Cancer Res. 52, 6394–6396.

Nagasawa H. Little J.B. , 1999. Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: evidence for a bystander effect. Radiat. Res. 152, 552–557.

Nagasawa H. Cremesti A. Kolesnick R. Fuks Z. Little J.B. , 2002. Involvement of membrane signaling in the bystander effect in irradiated cells. Cancer Res. 62, 2531–2534.

Nagasawa H. Huo L. Little J.B. , 2003. Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells. Int. J. Radiat. Biol. 79, 35–41.

Nakanishi M. Tanaka K. Shintani T. Takahashi T. Kamada N. , 1999. Chromosomal instability in acute myelocytic leukemia and myelodysplastic syndrome patients among atomic bomb survivors. J. Radiat. Res. 40, 159–167.

Nakanishi M. Tanaka K. Takahashi T. , 2001. Microsatellite instability in acute myelocytic leukaemia developed from A-bomb survivors. Int. J. Radiat. Biol. 77, 687–694. Also see comments in: Int. J. Radiat. Biol. 2002, 78, 441–445.

Narayanan P. Goodwin E. Lehnert B. , 1997. Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells. Cancer Res. 57, 3963–3971.

Narayanan P.K. LaRue K.E.A. Goodwin E.H. Lehnert B.E. , 1999. Alpha particles biological production of Il-8 in human cells. Radiat. Res. 152, 57–63.

NAS/NRC, 1980. Committee on the Biological Effects of Exposure to Low Levels of Ionizing Radiation: BEIR III. National Academy Press, Washington, DC.

NAS/NRC, 1999. Committee on Health Effects of Exposure to Radon. Health Effects of Exposure to Radon: BEIR VI. National Academy Press, Washington, DC.

NAS/NRC, 2000. Committee on an Assessment of Centers for Disease Control and Prevention Radiation Studies from DOE Contractor Sites: Subcommittee to Review the Radioepidemiology Tables. A Review of the Draft Report of the NCI-CDC Working Group to Revise the ‘1985 Radioepidemiological Tables’. National Research Council, Board on Radiation Effects Research, Washington, DC.

NCI/CDC, 2003. Report of the NCI-CDC Working Group to revise the 1985 NIH Radioepidemiological Tables. NIH Publication No. 03–5387. US Dept. of Health and Human Services, National Institutes of Health, National Cancer Institute, Bethesda, MD.

NCI/CDC, 2003. Report of the NCI/CDC Working Group to Revise the 1985 NIH Radioepidemiological Tables. NIH Publication No. 03–5387. US Dept. of Health and Human Services, National Institutes of Health, National Cancer Institute, Bethesda, MD.

NCRP, 1980. Influence of Dose and its Distribution in Time on Dose-response Relationships for Low-LET Radiations. NCRP Report No. 64. National Council on Radiation Protection and Measurements, Washington, DC.

NCRP, 1980. Influence of Dose and its Distribution in Time on Dose-response Relationships for Low-LET Radiations. NCRP Report No. 64. National Council on Radiation Protection and Measurements, Bethesda, MD.

NCRP, 1993. Limitation of Exposure to Ionizing Radiation. NCRP Report No. 116. National Council on Radiation Protection and Measurements, Bethesda, MD.

NCRP, 1996. A Guide for Uncertainty Analysis in Dose and Risk Assessments Related to Environmental Contamination. NCRP Commentary No. 14. National Council on Radiation Protection and Measurements, Bethesda, MD.

NCRP, 1997. Uncertainties in Fatal Cancer Risk Estimates Used in Radiation Protection. NCRP Report No. 126. National Council on Radiation Protection and Measurements, Bethesda, MD.

NCRP, 2000. Radiation Protection Guidance for Activities in Low-Earth Orbit. NCRP Report 132. National Council on Radiation Protection and Measurements, Bethesda, MD.

NCRP, 2001. Evaluation of the linear-nonthreshold dose-response model for ionizing radiation. NCRP Report No. 136. National Council on Radiation Protection and Measurements, Bethesda, MD.

Nekolla E.A. Kellerer A.M. Kuse-Isingschulte M. Eder E. Spiess H. , 1999. Malignancies in patients treated with high doses of radium-224. Radiat. Res. 152, S3–S7.