Abstract
Objective
To investigate whether topical agents of herbal origin used in traditional Chinese medicine (TCM) have real biological effects on limb swelling and tissue healing.
Methods
Formation of an innovative formula was achieved through a literature screening of over 200 herbs. The herbs selected have been reported to be anti-inflammatory, promoting circulation and supporting tissue/bone healing. In vitro and in vivo tests were done to investigate the biological effects of the herbs.
Results
Topical agent for tissue swelling: (a) The herbs were found to facilitate the transport of a chemical through an artificial membrane and porcine skin in a diffusion chamber; (b) the herbal bath was found to positively reduce hand and foot swelling. Topical agent for fracture healing: (a) In vitro tests showed positive anti-inflammatory, circulation promotion and tissue healing effects of a six herbs formula; (b) treated animals showed bigger callus, higher serum bone specific alkaline phosphatase and better mechanical strength; (c) liquid chromatography-mass spectrometry testing showed that there was a real transport of chemical markers across the skin.
Conclusion
TCM herbal agents used topically for hand swelling and tissue healing do have demonstrable scientific basis. Further research is justified.