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Retricted access

Research article

First published 2015-4

Understanding responder neurobiology in schizophrenia using a quantitative systems pharmacology model: Application to iloperidone

Hugo Geerts, Patrick Roberts, Athan Spiros [...]

Journal of Psychopharmacology

Open access

Review article

First published 2017

Linear-In-Flux-Expressions Methodology: Toward a Robust Mathematical Framework for Quantitative Systems Pharmacology Simulators

Sean T McQuade, Ruth E Abrams, Jeffrey S Barrett [...]

Gene Regulation and Systems Biology

Free access

Research article

First published 2016-7

A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine

Andrew M. Stern, Mark E. Schurdak, Ivet Bahar [...]

Journal of Biomolecular Screening

Open access

Research article

First published 2017

A Quantitative Systems Pharmacology Platform to Investigate the Impact of Alirocumab and Cholesterol-Lowering Therapies on Lipid Profiles and Plaque Characteristics

Jeffrey E Ming, Ruth E Abrams, Derek W Bartlett [...]

Gene Regulation and Systems Biology

Free access

Research article

First published 2013-11

Phenotypic Screening of the Prestwick Library for Treatment of Parkinson's Tremor Symptoms using a Humanized Quantitative Systems Pharmacology Platform

Athan Spiros, Patrick Roberts, Hugo Geerts

Journal of Parkinson’s Disease

Retricted access

Research article

First published 2020-10-27

Simulating the Effects of Common Comedications and Genotypes on Alzheimer’s Cognitive Trajectory Using a Quantitative Systems Pharmacology Approach

Hugo Geerts, Athan Spiros

Journal of Alzheimer’s Disease

Retricted access

Research article

First published 2021-11

Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors

Manush Saydmohammed, Anupma Jha, Vineet Mahajan [...]

Experimental Biology and Medicine

Open access

Review article

First published 2021-11-23

Computational Approaches for Supporting Combination Therapy in the Post-Aducanumab Era in Alzheimer’s Disease

Hugo Geerts, Piet van der Graaf

Journal of Alzheimer's Disease Reports

Open access

Research article

First published 2017

Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses

Lisl KM Shoda, Christina Battista, Scott Q Siler [...]

Gene Regulation and Systems Biology

Open access

Research article

First published 2018-11

Predicting parkinsonism side-effects of antipsychotic polypharmacy prescribed in secondary mental healthcare

Giouliana Kadra, Athan Spiros, Hitesh Shetty [...]

Journal of Psychopharmacology

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