Search results: Sage Journals

Open accessResearch articleFirst published July, 2026

An evaluation of designs for Phase I/IIa dose-finding studies in Tuberculosis

Alessandra Serra, Pavel Mozgunov, Patrick PJ Phillips [...]

Statistical Methods in Medical Research

Free accessResearch articleFirst published January, 2009

The Liver Toxicity Biomarker Study: Phase I Design and Preliminary Results

Robert N. Mcburney, Wade M Hines, Linda S. Von Tungeln [...]

Toxicologic Pathology

Restricted accessReview articleFirst published January, 2012

Flexible Phase I Study Designs

David Underwood

Therapeutic Innovation & Regulatory Science

Restricted accessResearch articleFirst published October, 1989

Challenges in the Design of Phase I and Early Phase II Studies

George S. Hughes

Therapeutic Innovation & Regulatory Science

Restricted accessResearch articleFirst published July, 1997

From Mouse to Man: The Early Clinical Testings

Kimberly T. Perry

Therapeutic Innovation & Regulatory Science

Restricted accessResearch articleFirst published December, 2019

Sequential or combined designs for Phase I/II clinical trials? A simulation study

Caroline Rossoni, Aurélie Bardet, Birgit Geoerger [...]

Clinical Trials

Restricted accessResearch articleFirst published January, 2015

Incorporating Historical Data in Bayesian Phase I Trial Design

Kentaro Takeda, Satoshi Morita

Therapeutic Innovation & Regulatory Science

Restricted accessResearch articleFirst published June, 2024

The 3 + 3 design in dose-finding studies with small sample sizes: Pitfalls and possible remedies

Cody Chiuzan, Hakim-Moulay Dehbi

Clinical Trials

Open accessResearch articleFirst published January, 2026

Joint time-to-event partial order continual reassessment method and Joint time-to-event Bayesian logistic regression model: Statistical designs for dual agent phase I/II dose finding studies with late-onset toxicity and activity outcomes

Helen Barnett, Oliver Boix, Dimitris Kontos [...]

Statistical Methods in Medical Research

Free accessResearch articleFirst published February, 2012

Pharmacokinetics and Antiviral Activity of Phx1766,a Novel HCV Protease Inhibitor,Using An Accelerated Phase I Study Design

Daphne M Hotho, Joep de Bruijne, A Marie O'Farrell [...]

Antiviral Therapy

Open accessResearch articleFirst published July, 2026

An evaluation of designs for Phase I/IIa dose-finding studies in Tuberculosis

Alessandra Serra, Pavel Mozgunov, Patrick PJ Phillips [...]

Statistical Methods in Medical Research

Free accessResearch articleFirst published January, 2009

The Liver Toxicity Biomarker Study: Phase I Design and Preliminary Results

Robert N. Mcburney, Wade M Hines, Linda S. Von Tungeln [...]

Toxicologic Pathology

Restricted accessReview articleFirst published January, 2012

Flexible Phase I Study Designs

David Underwood

Therapeutic Innovation & Regulatory Science

Restricted accessResearch articleFirst published October, 1989

Challenges in the Design of Phase I and Early Phase II Studies

George S. Hughes

Therapeutic Innovation & Regulatory Science

Restricted accessResearch articleFirst published July, 1997

From Mouse to Man: The Early Clinical Testings

Kimberly T. Perry

Therapeutic Innovation & Regulatory Science

Restricted accessResearch articleFirst published December, 2019

Sequential or combined designs for Phase I/II clinical trials? A simulation study

Caroline Rossoni, Aurélie Bardet, Birgit Geoerger [...]

Clinical Trials

Restricted accessResearch articleFirst published January, 2015

Incorporating Historical Data in Bayesian Phase I Trial Design

Kentaro Takeda, Satoshi Morita

Therapeutic Innovation & Regulatory Science

Restricted accessResearch articleFirst published June, 2024

The 3 + 3 design in dose-finding studies with small sample sizes: Pitfalls and possible remedies

Cody Chiuzan, Hakim-Moulay Dehbi

Clinical Trials

Open accessResearch articleFirst published January, 2026

Joint time-to-event partial order continual reassessment method and Joint time-to-event Bayesian logistic regression model: Statistical designs for dual agent phase I/II dose finding studies with late-onset toxicity and activity outcomes

Helen Barnett, Oliver Boix, Dimitris Kontos [...]

Statistical Methods in Medical Research

Free accessResearch articleFirst published February, 2012

Pharmacokinetics and Antiviral Activity of Phx1766,a Novel HCV Protease Inhibitor,Using An Accelerated Phase I Study Design

Daphne M Hotho, Joep de Bruijne, A Marie O'Farrell [...]

Antiviral Therapy