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Case report

First published 2013-5

Optimizing Drug Development Programs

Zoran Antonijevic, Martin Kimber, David Manner [...]

Therapeutic Innovation & Regulatory Science

Open access

Research article

First published 2020-4

Two-Step Optimization to Develop a Transdermal Film Loaded With Dapoxetine Nanoparticles: A Promising Technique to Improve Drug Skin Permeation

Tarek A. Ahmed, Asmaa M. S. Alay, Solomon Z. Okbazghi [...]

Dose-Response

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Review article

First published 1998-5

Book Reviews : Optimizing the Development of Antipsychotic Drugs

Brett Broster, Serdar Dursun

Journal of Psychopharmacology

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Research article

First published 2020-11

Pharmacological Optimization for Successful Traumatic Brain Injury Drug Development

Samuel M. Poloyac, Richard J. Bertz, Lee A. McDermott [...]

Journal of Neurotrauma

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Research article

First published 2024-6

Current issues in dose-finding designs: A response to the US Food and Drug Adminstration’s Oncology Center of Excellence Project Optimus

Peter F Thall, Elizabeth Garrett-Mayer, Nolan A Wages [...]

Clinical Trials

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Research article

First published 2017-1

Methodological Extensions of Phase 2 Trial Designs Based on Program-Level Considerations

James Bolognese, Jaydeep Bhattacharyya, Chris Assaid [...]

Therapeutic Innovation & Regulatory Science

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Research article

First published 2017-12

The SPOTS System: An Ocular Scoring System Optimized for Use in Modern Preclinical Drug Development and Toxicology

Joshua Seth Eaton, Paul E. Miller, Ellison Bentley [...]

Journal of Ocular Pharmacology and Therapeutics

Open access

Research article

First published 2021-6

A method for systematically ranking therapeutic drug candidates using multiple uncertain screening criteria

Xubiao Peng, Ebrima Gibbs, Judith M Silverman [...]

Statistical Methods in Medical Research

Open access

Research article

First published 2007

Lead Optimization in Discovery Drug Metabolism and Pharmacokinetics/Case study: The Hepatitis C Virus (HCV) Protease Inhibitor SCH 503034

K.-C. Cheng, Walter A. Korfmacher, Ronald E. White [...]

Perspectives in Medicinal Chemistry

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Research article

First published 2013-9

A Modeling and Simulations Framework to Support Global Regulatory Strategies for Pediatric Drug Development Programs

Jean-Francois Marier, Barry Mangum, Betsy Reid [...]

Therapeutic Innovation & Regulatory Science

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