Sage Journals: Discover world-class research

Open access

Research article

First published 2020-4

Safety,tolerability,and pharmacokinetics of the selective prostacyclin receptor agonist ralinepag in single and multiple dosing studies of an immediate-release oral formulation in healthy volunteers

John S. Grundy, Christopher D. King, John W. Adams [...]

Pulmonary Circulation

Retricted access

Research article

First published 1997-6

Safety,Tolerability,and Pharmacokinetics of Sumatriptan in Healthy Subjects Following Ascending Single Intranasal Doses and Multiple Intranasal Doses

KHP Moore, EK Hussey, S Shaw [...]

Cephalalgia

Retricted access

Research article

First published 2018-2

Safety and pharmacodynamics of venetoclax (ABT-199) in a randomized single and multiple ascending dose study in women with systemic lupus erythematosus

P Lu, R Fleischmann, C Curtis [...]

Lupus

Free access

Research article

First published 2021-1

Pharmacokinetics,safety and tolerability of single- and multiple-ascending doses of JNJ-64530440,a novel hepatitis B virus capsid assembly modulator,in healthy volunteers

Thomas N Kakuda, Jeysen Z Yogaratnam, Christopher Westland [...]

Antiviral Therapy

Open access

Research article

First published 2017-12

A double-blind,placebo-controlled,single ascending-dose study of remyelinating antibody rHIgM22 in people with multiple sclerosis

Andrew Eisen, Benjamin M Greenberg, James D Bowen [...]

Multiple Sclerosis Journal – Experimental,Translational and Clinical

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Research article

First published 2012-8

Orexin receptor antagonism: an ascending multiple-dose study with almorexant

Petra Hoever, Sanne L de Haas, Georg Dorffner [...]

Journal of Psychopharmacology

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Research article

First published 2024-03-19

First-In-Human Safety,Tolerability,and Pharmacokinetics of Single and Multiple Doses of AZP2006,A Synthetic Compound for the Treatment of Alzheimer’s Disease and Related Diseases

Philippe Verwaerde, Cecilia Estrella, Stéphane Burlet [...]

Journal of Alzheimer’s Disease

Retricted access

Research article

First published 2016-4-12

Two Phase 2 Multiple Ascending–Dose Studies of Vanutide Cridificar (ACC-001) and QS-21 Adjuvant in Mild-to-Moderate Alzheimer’s Disease

Florence Pasquier, Carl Sadowsky, Ann Holstein [...]

Journal of Alzheimer’s Disease

Free access

Research article

First published 2018-10

Phase I Study on Safety and Pharmacokinetics of a Novel Influenza Endonuclease Inhibitor,AL-794 (JNJ-64155806),following Single- and Multiple-Ascending doses in Healthy Adults

Thomas N Kakuda, Jeysen Yogaratnam, Jennifer Rito [...]

Antiviral Therapy

Open access

Research article

First published 2021-08

Safety,Tolerability,and Pharmacokinetics of RT234 (Vardenafil Inhalation Powder): A First-in-Human,Ascending Single- and Multiple-Dose Study in Healthy Subjects

Michael A. Eldon, Edwin L. Parsley, Mari Maurer [...]

Journal of Aerosol Medicine and Pulmonary Drug Delivery

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