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Research article

First published 2026-4

Conjugated Antisense Oligonucleotides for Skipping of Duchenne Muscular Dystrophy Exon 53: A Cautionary Study

Emma T. Groenwold, Alicia Montulet, Tiberiu Stan [...]

Nucleic Acid Therapeutics

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Review article

First published 2002-04

Oligonucleotide Conjugates as Potential Antisense Drugs with Improved Uptake,Biodistribution,Targeted Delivery,and Mechanism of Action

Muthiah Manoharan

Nucleic Acid Therapeutics

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Research article

First published 2019-10

Lipid Conjugates Enhance Endosomal Release of Antisense Oligonucleotides Into Cells

Shiyu Wang, Nickolas Allen, Thazha P. Prakash [...]

Nucleic Acid Therapeutics

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Research article

First published 2018-02

Cholesterol–GalNAc Dual Conjugation Strategy for Reducing Renal Distribution of Antisense Oligonucleotides

Fumito Wada, Tsuyoshi Yamamoto, Tetsuya Ueda [...]

Nucleic Acid Therapeutics

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Research article

First published 2012-10

Potent Antibacterial Antisense Peptide–Peptide Nucleic Acid Conjugates Against Pseudomonas aeruginosa

Anubrata Ghosal, Peter E. Nielsen

Nucleic Acid Therapeutics

Open access

Research article

First published 2023-02

Integrated Assessment of Phase 2 Data on GalNAc 3 -Conjugated 2′- O -Methoxyethyl-Modified Antisense Oligonucleotides

Brenda F. Baker, Shuting Xia, Wesley Partridge [...]

Nucleic Acid Therapeutics

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Brief report

First published 2017-08

Gene Silencing Activity and Hepatic Accumulation of Antisense Oligonucleotides Bearing Cholesterol-Conjugated Thiono Triester at the Gap Region

Mado Nakajima, Takeshi Kasuya, Shinnichi Yokota [...]

Nucleic Acid Therapeutics

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Research article

First published 2016-12

Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys

Rosie Z. Yu, Rudy Gunawan, Noah Post [...]

Nucleic Acid Therapeutics

Open access

Research article

First published 2024-02

Safety and Tolerability of GalNAc 3 -Conjugated Antisense Drugs Compared to the Same-Sequence 2′- O -Methoxyethyl-Modified Antisense Drugs: Results from an Integrated Assessment of Phase 1 Clinical Trial Data

Brenda F. Baker, Shuting Xia, Wesley Partridge [...]

Nucleic Acid Therapeutics

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Research article

First published 2021-08

Interspecies Scaling of Human Clearance and Plasma Trough Exposure for Antisense Oligonucleotides: A Retrospective Analysis of GalNAc3-Conjugated and Unconjugated-Antisense Oligonucleotides

Charvi Nanavati, Gina Mcmullen, Rosie Yu [...]

Nucleic Acid Therapeutics

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