Background:

Short-acting reversible contraceptives (SACs) are birth control methods with proven additional benefits beyond contraception. Even so, specific evidence on which SAC formulation is the most effective for a particular noncontraceptive benefit is still lacking. This study aimed to investigate the superiority of specific SAC formulations over others for particular extracontraception benefits.

Materials and Methods:

A literature search of systematic reviews and/or meta-analyses providing data on the noncontraceptive clinical benefits of SAC versus other SAC formulations or SAC versus placebo or no treatment, including the period from 2014 to 2024, was conducted. Information was extracted as individual items and classified into predefined objective health benefits.

Results:

A total of 70 articles were included in the review, with 52 items describing additional benefits of SAC versus other SAC formulations and 86 items of SAC versus placebo or no treatment. Most of the items reported information on polycystic ovary syndrome, followed by androgenism and endometriosis. For consistency, the reported clinical benefits were reclassified into five broad categories: gynecological disorders, cancer protection, menstrual bleeding disorders, hyperandrogenic conditions, and miscellanea.

Conclusions:

The use of SAC is accompanied by a range of health benefits beyond contraception that should be taken into account when prescribing. Distinguishing the particular benefits of different SAC formulations may help support informed, women-centered prescription in clinical practice.

Search results

Beyond Contraception: Exploring Health Benefits of Short-Acting Reversible Contraceptives—A Narrative Review