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Research article

First published 2025-12

A Workflow for Transcriptome-Wide Assessment of Antisense Oligonucleotide Selectivity

Sagar S. Damle, Andy Watt, Steven Kuntz [...]

Nucleic Acid Therapeutics

Open access

Research article

First published 2022-10

The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2′- O -Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs

Lingdi Zhang, Xue-Hai Liang, Cheryl Li de Hoyos [...]

Nucleic Acid Therapeutics

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Research article

First published 2018-02

Cholesterol–GalNAc Dual Conjugation Strategy for Reducing Renal Distribution of Antisense Oligonucleotides

Fumito Wada, Tsuyoshi Yamamoto, Tetsuya Ueda [...]

Nucleic Acid Therapeutics

Open access

Research article

First published 2022-06

Differential Uptake of Antisense Oligonucleotides in Mouse Hepatocytes and Macrophages Revealed by Simultaneous Two-Photon Excited Fluorescence and Coherent Raman Imaging

Prabuddha Mukherjee, Edita Aksamitiene, Aneesh Alex [...]

Nucleic Acid Therapeutics

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Research article

First published 2018-08

Chronic Toxicity Assessment of 2′- O -Methoxyethyl Antisense Oligonucleotides in Mice

Thomas A. Zanardi, Tae-Won Kim, Lijiang Shen [...]

Nucleic Acid Therapeutics

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Research article

First published 2021-12

Investigation of the Activity of Antisense Oligonucleotides Targeting Multiple Genes by RNA-Sequencing

Sven Michel, Richard Klar, Frank Jaschinski

Nucleic Acid Therapeutics

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Research article

First published 1994-3

Selection of Antisense Oligonucleotides on the Basis of Genomic Frequency of the Target Sequence

Jian Han, Zhou Zhu, Chuancheih Hsu [...]

Nucleic Acid Therapeutics

Open access

Research article

First published 2020-08

Likelihood of Nonspecific Activity of Gapmer Antisense Oligonucleotides Is Associated with Relative Hybridization Free Energy

Andrew T. Watt, Grant Swayze, Eric E. Swayze [...]

Nucleic Acid Therapeutics

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Research article

First published 2006-12

Suppression of Tumor Growth Using Antisense Oligonucleotide Against Survivin in an Orthotopic Transplant Model of Human Hepatocellular Carcinoma in Nude Mice

Yuning Sun, Ruxian Lin, Jinming Dai [...]

Nucleic Acid Therapeutics

Open access

Review article

First published 2018

Antisense oligonucleotides in neurological disorders

Claudia D. Wurster, Albert C. Ludolph

Therapeutic Advances in Neurological Disorders

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