The role of MRI in predicting Ki-67 in breast cancer: preliminary results from a prospective study

Abstract

Purpose:

In the last decade contrast-enhanced magnetic resonance imaging (MRI) has gained a growing role as a complementary tool for breast cancer diagnosis. Currently the relationship between the kinetic features of a breast lesion and pathologic prognostic factors has become a popular field of research. Our aim is to verify whether breast MRI could be considered a useful tool to predict Ki-67 score, thus resulting as a breast cancer prognosis indicator.

Methods:

From June to December 2014, we enrolled patients with breast cancer who underwent preoperative dynamic contrast-enhanced MRI at the local health agency. We analyzed the time-signal intensity curves calculating the mean values of the following parameters: the basal enhancement (E_base), the enhancement ratio (ENH_ratio), the maximum enhancement (E_max), and the steepest slope of the contrast enhancement curve (S_max). Scatterplots and Pearson correlation test were used to investigate the eventual associations among these parameters.

Results:

A total of 27 patients underwent breast MRI during the study period. The mean ± SD Ki-67 percentage was 27.03 ± 16.8; the mean E_max, S_max, E_base, and ENH_ratio were 433.9 ± 120.2, 267.3 ± 96.8, 165.5 ± 77.1, and 187.1 ± 94.8, respectively. Scatterplots suggest a positive correlation between Ki-67 and both E_max and S_max. The correlation tests between Ki-67 and E_max, Ki-67 and S_max showed statistical significance.

Conclusions:

Our preliminary data suggest that enhancement pattern is closely linked to breast cancer proliferation, thus proving the relationship between more proliferating tumors and more rapidly enhanced lesions. This is hypothesis-generating for further studies aimed at promoting breast MRI in the early estimation of cancer prognosis and tumor in vivo response to chemotherapy.