Peritoneal carcinomatosis from hepatocellular carcinoma is well regarded as a poorly treatable malignant disease with rapid decline. Over the past decade, new modalities that combine cytoreductive surgery with perioperative hyperthermic intraperitoneal chemotherapy have been shown to be aggressive local-regional treatments with improved survival. We present a case of a 67-year-old non-cirrhotic woman with peritoneal metastases from hepatocellular caracinoma who was treated with cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy. Consideration remains individualized, but it can be considered in patients with adequate preservation of liver function, management of their primary hepatocellular caracinoma as well as the localized nature of their peritoneal metastases.
UkaK., AikataH., TakakiS.. Similar effects of recombinant interferon-α-2b and natural interferon-α when combined with intra-arterial 5-fluorouracil for the treatment of advanced hepatocellular carcinoma. Liver Int.2007; 27: 1209–1216.
2.
MatsukumaS., SatoK.Peritoneal seeding of hepatocellular carcinoma: clinicopathological characteristics of 17 autopsy cases. Pathol Int.2011. 61: 356–362.
3.
NatsuizakaM., OmuraT., AkaikeT.. Clinical features of hepatocellular carcinoma with extrahepatic metastases. J Gastroenterol Hepatol.2005; 20: 1781–1787.
4.
HungM.C., WuH.S., LeeY.T., HsuC.H., ChouD.A., HuangM.H.Intraperitoneal metastasis of hepatocellular carcinoma after spontaneous rupture: a case report. World J Gastroenterol.2008; 14: 3927.
5.
OkusakaT., OkadaS., IshiiH.. Prognosis of hepatocellular carcinoma patients with extrahepatic metastases. Hepatogastroenterol.1996; 44: 251–257.
6.
SaltiG.I., AilabouniL., UndeviaS.Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for the treatment of peritoneal sarcomatosis. Ann Surg Oncol.2012; 19: 1410–1415.
7.
LinC.C., LiangH.P., LeeH.S.. Clinical manifestations and survival of hepatocellular carcinoma patients with peritoneal metastasis. J Gastroenterol Hepatol.2009; 24: 815–820.
8.
LaiE.C., LauW.Y.Spontaneous rupture of hepatocellular carcinoma: a systematic review. Arch Surg.2006; 141: 191–198.
9.
NatsuizakaM., OmuraT., AkaikeT.. Clinical features of hepatocellular carcinoma with extrahepatic metastases. J Gastroenterol Hepatol.2005; 20: 1781–1787.
KwakM.S., LeeJ.H., YoonJ.H.. Risk factors, clinical features, and prognosis of the hepatocellular carcinoma with peritoneal metastasis. Dig Dis Sci.2012; 57: 813–819.
12.
HashimotoM., SasakiK., MoriyamaJ., MatsudaM., WatanabeG.Resection of peritoneal metastases in patients with hepatocellular carcinoma. Surgery.2013; 153: 727–731.
13.
NakashimaT., OkudaK., KojiroM.. Pathology of hepatocellular carcinoma in Japan: 232 consecutive cases autopsied in ten years. Cancer.1983; 51: 863–877.
14.
EsquivelJ., SticcaR., SugarbakerP.. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Ann Surg Oncol.2007; 14: 128–133.
15.
ChuaT.C., MorrisD.L.Exploring the role of resection of extrahepatic metastases from hepatocellular carcinoma. Surg Oncol.2012; 21: 95–101.
16.
DingJ.H., ChuaT.C., Al-MohaimeedK., MorrisD.L.Hepatocellular carcinoma peritoneal metastases: report of three cases and collective review of the literature. Ann Acad Med, Singapore.2010; 39: 734–734.
KoppeM.J., BoermanO.C., OyenW.J., BleichrodtR.P.Peritoneal carcinomatosis of colorectal origin: incidence and current treatment strategies. Ann Surg.2006; 243: 212–222.
19.
El-KarehA.W., SecombT.W.A theoretical model for intraperitoneal delivery of cisplatin and the effect of hyperthermia on drug penetration distance. Neoplasia.2004; 6: 117–127.
20.
TabrizianP., ShragerB., JibaraG.. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis: outcomes from a single tertiary institution. J Gastrointest Surg.2014; 18: 1024–1031.
