Exchange arthroplasty remains the gold standard of treatment of established prosthetic joint infection. This can be achieved using a one or two stage approach. The ENDO-Klinik, in Hamburg, has pioneered the one-stage technique since 1970 utilising antibiotic loaded acrylic cement (ALAC). This editorial discusses the relevant literature and describes the indications and surgical technique employed by the ENDO-Klinik Hamburg.
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