To assess choroidal thickness in patients with migraine and compare them with healthy controls, using spectral-domain optical coherence tomography (OCT).
Methods
In this prospective case-control study, choroidal thicknesses of 20 newly diagnosed migraine patients and 20 age- and sex-matched healthy subjects were measured using a high-speed, high-resolution frequency domain (FD) OCT device (λ = 840 nm, 26.000 A-scans/s, 5 µm axial resolution). All patients underwent a complete ophthalmic examination before the measurements. OCT measurements were taken at the same time of day (9:00 AM), in order to minimize the effects of diurnal variation.
Results
There was a statistically significant difference in median choroidal thickness between the migraine patients (277.00 [interquartile range (IQR) 85.75] µm) and controls (301.00 [IQR 90.50] µm) (p = 0.012). There were significant differences at all measurement points (p<0.05 for all).
Conclusions
The decreased choroidal thickness of patients with migraine might be related to the vascular pathology of the disease. Further studies are needed to evaluate the etiopathologic relationship between choroidal thickness and migraine.
Get full access to this article
View all access options for this article.
References
1.
PanconesiABartolozziMLGuidiLMigraine pain: reflections against vasodilatation. J Headache Pain. 2009;10:317–25.
2.
ThieASpitzerKLachenmayerLKunzeKProlonged vasospasm in migraine detected by noninvasive transcranial Doppler ultrasound. Headache. 1988;28:183–6.
3.
KomatsuKFukutakeTHattoriTFingertip photoplethysmography and migraine. J Neurol Sci. 2003;15:17–21.
4.
AminFMAsgharMSHougaardAMagnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study. Lancet Neurol. 2013;12:454–61.
5.
CharlesAVasodilation out of the picture as a cause of migraine headache. Lancet Neurol. 2013;12:419–20.
6.
SugiyamaTAraieMRivaCESchmettererLOrgulSUse of laser speckle flowgraphy in ocular blood flow research. Acta Ophthalmol. 2010;88:723–9.
7.
PortmannNGugletaKKochkorovAPoluninaAFlammerJOrgulSChoroidal blood flow response to isometric exercise in glaucoma patients and patients with ocular hypertension. Invest Ophthalmol Vis Sci. 2011;52:7068–73.
8.
BillACirculation in the eye. InRenkinEMMichelCCedsHandbook in Physiology: Microcirculation, Part 2Bethesda, MD: The American Physiological Society1984;1001–35.
9.
ManjunathVTahaMFujimotoJGDukerJSChoroidal thickness in normal eyes measured using Cirrus-HD optical coherence tomography. Am J Ophthalmol. 2010;150:325–9.
10.
BranchiniLRegatieriCVFlores-MorenoIBaumannBFujimotoJGDukerJSReproducibility of choroidal thickness measurements across the three spectral domain optical coherence tomography systems. Ophthalmology. 2012;119:119–23.
11.
VanceSImamuraYFreundKBThe effects of sildenafil citrate on choroidal thickness as determined by enhanced depth imaging optical coherence tomography. Retina. 2011; 31 332–5.
12.
ManjunathVGorenJFujimotoJGDukerJSAnalysis of choroidal thickness in age-related macular degeneration using spectral-domain optical coherence tomography. Am J Ophthalmol. 2011;152:663–8.
13.
MaulEAFriedmanDSChangDSChoroidal thickness measured by spectral domain optical coherence tomography: factors affecting thickness in glaucoma patients. Ophthalmology. 2011;118:1571–9.
FujiwaraTImamuraYMargolisRSlakterJSSpaideRFEnhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes. Am J Ophthalmol. 2009;148:445–50.
17.
TanCSOuyangYRuizHSaddaSRDiurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2012;53:261–6.
18.
PolskaEPolakKLukschATwelve hour reproducibility of choroidal blood flow parameters in healthy subjects. Br J Ophthalmol. 2004;88:533–7.
19.
FitzgeraldMEWildsoetCFReinerATemporal relationship of choroidal blood flow and thickness changes during recovery from form deprivation myopia in chicks. Exp Eye Res. 2002;74:561–70.
20.
KimDYSilvermanRHChanRVPMeasurement of choroidal perfusion and thickness following systemic sildenafil (Viagra). Acta Ophthalmol. 2013;91:183–8.
21.
SogawaKNagaokaTTakahashiATananoITaniTIshibazawaARelationship between choroidal thickness and choroidal circulation in healthy young subjects. Am J Ophthalmol. 2012;153:1129–32.
IkunoYTanoYRetinal and choroidal biometry in highly myopic eyes with spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2009;50:3876–80.
24.
YeohJRahmanWChenFChoroidal imaging in inherited retinal disease using the technique of enhanced depth imaging optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2010;248:1719–28.
25.
SpaideRFAge-related choroidal atrophy. Am J Ophthalmol. 2009;147:801–10.
26.
ImamuraYFujiwaraTMargolisRSpaideRFEnhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy. Retina. 2009;29:1469–73.
27.
MarukoIIidaTSuganoYOjimaAOgasawaraMSpaideRFSubfoveal choroidal thickness after treatment of central serous chorioretinopathy. Ophthalmology. 2010;117:1792–9.
28.
MarukoIIidaTSuganoYSubfoveal choroidal thickness after treatment of Vogt-Koyanagi-Harada disease. Retina. 2011;31:510–7.
29.
HirookaKTenkumoKFujiwaraABabaTSatoSShiragaFEvaluation of peripapillary choroidal thickness in patients with normal-tension glaucoma. BMC Ophthalmol Epub. 2012Jul28.
30.
BroadwayDCDranceSMGlaucoma and vasospasm. Br J Ophthalmol. 1998;82:862–70.
