In this article we report on the current role of radiotherapy in the management of non-muscle invasive as well as in muscle invasive bladder cancer.
Radiotherapy seems to have no role in non-muscle invasive bladder cancer.
In muscle invasive bladder tumors, the role of radiotherapy is under investigation in view of new radiotherapy techniques and novel cytotoxic and biological agents.
WolfH., OlsenP.R., HøjgaardK.Urothelial dysplasia concomitant with bladder tumours: a determinant for future new occurrences in patients treated by full-course radiotherapy. Lancet.1985 May 4; 1(8436): 1005–8.
2.
RödelC., DunstJ., GrabenbauerG.G., KühnR., PapadopoulosT., SchrottK.M., SauerR.Radiotherapy is an effective treatment for high-risk T1-bladder cancer. Strahlenther Onkol.2001 Feb; 177(2): 82–8.
3.
HarlandS.J., KynastonH., GrigorK., WallaceD.M., BeacockC., KockelberghR., ClawsonS., BarlowT., ParmarM.K., GriffithsG.O.A randomized trial of radical radiotherapy for the management of pT1G3 NXM0 transitional cell carcinoma of the bladder. J Urol.2007 Sep; 178: 807–13.
4.
FossaS.D., AassN., OusS., WaehreH., IlnerK., HannisdalE.Survival after curative treatment of muscle-invasive bladder cancer. Acta Oncol.1996; 35 Suppl 8: 59–65.
5.
CookeP.W., DunnJ.A., LatiefT., BathersS., JamesN.D., WallaceD.M.Long-term risk of salvage cystectomy after radiotherapy for muscle-invasive bladder cancer. Eur Urol.2000 Sep; 38(3): 279–86.
6.
DæhlinL., HaukaasS., Maartmann-Moe, MedbyP.C.Survival after radical treatment for transitional cell carcinoma of the bladder. Eur J Surg Oncol.1999; 25: 66–70.
PosF.J., HartG., SchneiderC., SminiaP.Radical radiotherapy for invasive bladder cancer: What dose and fractionation schedule to choose?Int J Radiat Oncol Biol Phys.2006 Mar 15;64(4): 1168–73.
KobD., ArndtJ., KriesterA., SchwenkM., KloetzerK.H.Results of percutaneous radiotherapy of bladder cancer using 1 and 2 series of irradiation. Strahlentherapie.1985 Nov; 161(11): 673–7.
11.
NieuwenhuijzenJ.A., PosF., MoonenL.M., HartA.A., HorenblasS.Survival after bladder-preservation with brachytherapy versus radical cystectomy; a single institution experience. Eur Urol.2005; 48: 239–45.
12.
PosF, HorenblasS., DomP, MoonenL., BartelinkH.Organ preservation in invasive bladder cancer: brachytherapy, an alternative to cystectomy and combined modality treatment?Int J Radiat Oncol Phys.2005; 61: 678–86.
13.
TesterW., PorterA., AsbellS., CoughlinC., HeaneyJ., KrallJ., MartzK., VennerP., HammondE.Combined modality program with possible organ preservation for invasive bladder carcinoma: results of RTOG protocol 85-12. Int J Radiat Oncol Biol Phys.1993 Apr 2; 25(5): 783–90.
14.
DanesiD.T., ArcangeliG., CrucianiE., AltavistaP., MecozziA., SaracinoB., OreficiF.Coppin CM, Conservative treatment of invasive bladder carcinoma by transurethral resection, protracted intravenous infusion chemotherapy, and hyperfractionated radiotherapy: long term results. Cancer.2004 Dec 1; 101(11): 2540–8.
15.
GospodarowiczM.K., JamesK., TannockI.F., ZeeB., CarsonJ., PaterJ., SullivanL.D.Improved local control of invasive bladder cancer by concurrent cisplatin and preoperative or definitive radiation. The National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol.1996 Nov; 14(11): 2901–7.
16.
JamesN.D., HussainS.A., HallE., JenkinsP, TremlettJ., RawlingsC., CrundwellM., SizerB., SreenivasanT., HendronC., LewisR., WatersR., HuddartRA; BC2001 Investigators. Radiotherapy with or without chemotherapy in muscle-invasive bladder cancer. N Engl J Med.2012 Apr 19; 366(16): 1477–88.
17.
WeissC., and RödelC.Chemoradiation superior in muscle invasive bladder cancer. Nat Rev Clin Oncol.2012; 9: 374–375.