TO describe breast cancer as a source of choroidal metastasis in men and highlight the diagnostic and treatment modalities.
Methods
Retrospective, noncomparative case series of male patients with breast cancer metastatic to the choroid. A literature review of the previously reported cases was also conducted.
Results
Three cases of breast cancer metastatic to the choroid in male patients from one institution are described. All 3 patients eventually underwent treatment with radiotherapy.
Conclusions
Breast cancer is a rare cause of choroidal metastases in men. Radiotherapy is effective as a palliative treatment for choroidal metastases.
DieingA., SchulzC.O., SchmidP.Orbital metastases in breast cancer: report of two cases and review of the literature. J Cancer Res Clin Oncol2004; 130: 745–8.
3.
MewisL., YoungS.E.Breast carcinoma metastatic to the choroid: analysis of 67 patients. Ophthalmology1982; 89: 147–51.
4.
NelsonC.C., HertzbergB.S., KlintworthG.K.A histopathologic study of 716 unselected eyes in patients with cancer at the time of death. Am J Ophthalmol1983; 95: 788–93.
5.
GiordanoS.H., BuzdarA.U., HortobagyiG.N.Breast cancer in men [see comment]. Ann Intern Med2002; 137: 678–87.
6.
WeissL.Comments on hematogenous metastatic patterns in humans as revealed by autopsy. Clin Exp Metastasis1992; 10: 191–9.
7.
FerryA.P., FontR.L.Carcinoma metastatic to the eye and orbit: I: a clinicopathologic study of 227 cases. Arch Ophthalmol1974; 92: 276–86.
8.
AlbertD.M., ZimmermannA.W.Jr., ZeidmanI.Tumor metastasis to the eye: 3: the fate of circulating tumor cells to the eye. Am J Ophthalmol1967; 63: 733–8.
9.
KreuselK.M., HeimannH., WiegelT., BornfeldN., FoersterM.H.Choroidal metastasis in men with metastatic breast cancer. Am J Ophthalmol1999; 128: 253–5.
10.
DemirciH., ShieldsC.L., ChaoA.N., ShieldsJ.A.Uveal metastasis from breast cancer in 264 patients. Am J Ophthalmol2003; 136: 264–71.
11.
CohenV.M., MoosaviR., HungerfordJ.L.Tamoxifen-induced regression of a choroidal metastasis in a man. Arch Ophthalmol2005; 123: 1153–4.
12.
ChenY.R., LinT.H., ChanS.M.Bilateral choroidal metastases as the initial presentation of a small breast carcinoma: a case report. Zhonghua Yi Xue Za Zhi1998; 61: 99–103.
13.
WilliamsN.J., LerisA.C., KouriefsC., MokbelK.M., HungerfordJ., CarpenterR.Choroidal metastasis-the initial presentation of breast carcinoma. Eur J Surg Oncol2000; 26: 817–8.
14.
FerryA.P.Metastatic carcinoma of the eye and ocular adnexa. Int Ophthalmol Clin1967; 7: 615–58.
15.
WiegelT., KreuselK.M., BornfeldN.Frequency of asymptomatic choroidal metastasis in patients with disseminated breast cancer: results of a prospective screening programme. Br J Ophthalmol1998; 82: 1159–61.
16.
AlbertD.M., RubensteinR.A., ScheieH.G.Tumor metastasis to the eye: I: incidence in 213 adult patients with generalized malignancy. Am J Ophthalmol1967; 63: 723–6.
17.
MerrillC.F., KaufmanD.I., DimitrovN.V.Breast cancer metastatic to the eye is a common entity. Cancer1991; 68: 623–7.
18.
PaoliD.Regression of choroidal metastasis from a carcinoma of the male breast: case report. Ophthalmologica1998; 212(Suppl 1): S74–6.
19.
ShomeD., JayadevC., GadgilD., NatarajanS., JainV.Systemic chemotherapy and tamoxifen induced regression of choroidal metastasis from a breast carcinoma in a male. Indian J Ophthalmol2007; 55: 475–7.
20.
ThatcherN., ThomasP.R.Choroidal metastases from breast carcinoma: a survey of 42 patients and the use of radiation therapy. Clin Radiol1975; 26: 549–53.
WiegelT., BottkeD., KreuselK.M.External beam radiotherapy of choroidal metastases: final results of a prospective study of the German Cancer Society (ARO 95–08). Radiother Oncol2002; 64: 3–18.
23.
RudolerS.B., CornB.W., ShieldsC.L.External beam irradiation for choroid metastases: identification of factors predisposing to long-term sequelae. Int J Radiat Oncol Biol Phys1997; 38: 251–6.
24.
ShieldsC.L., ShieldsJ.A., De PotterP.Plaque radiotherapy for the management of uveal metastasis. Arch Ophthalmol1997; 115: 203–9.
25.
BrownG.C., ShieldsJ.A., SanbornG., AugsburgerJ.J., SchatzN.J., SavinoP.J.Radiation retinopathy. Trans Pa Acad Ophthalmol Otolaryngol1981; 34: 144–51.
26.
MonroeA.T., BhandareN., MorrisC.G., MendenhallW.M.Preventing radiation retinopathy with hyperfractionation. Int J Radiat Oncol Biol Phys2005; 61: 856–64.
27.
PillatA.Ueber Auftreten und Verlauf von Aderhautmetastasen bei Brustkrebs des Mannes. Wiener Klinische Wochenschrift1952; 64: 222–4.
28.
GreerC.H.Choroidal carcinoma metastatic from the male breast. Br J Ophthalmol1954; 38: 312–5.
29.
WeisingerH.Bilateral uveal metastasis from carcinoma of the breast. South Med J1966; 59: 1199–202.
30.
LakhanpalV., KareshJ., SchocketS., NirankariV.S.Bilateral choroidal metastases from male breast carcinoma. Ann Ophthalmol1982; 14: 982–4.
31.
ReynardM., FontR.L.Two cases of uveal metastasis from breast carcinoma in men. Am J Ophthalmol1983; 95: 208–15.
32.
SchlaenN.D., NavesA.E.Orbital and choroidal metastases from carcinoma of the male breast. Arch Ophthalmol1986; 104: 1344–6.
33.
GonversM., ZografosL.Choroidal metastasis and rhegmatogenous retinal detachment. Retina1991; 11: 426–9.
34.
O'BrienJ., WielandM., FilerR.Breast cancer metastatic to the choroid in a male patient. Retina2000; 20: 214–6.
35.
LamA., ShieldsC.L., ShieldsJ.A.Uveal metastases from breast carcinoma in three male patients. Ophthalmic Surg Lasers Imaging2006; 37: 320–3.
36.
SilvestrisN., Di CosimoS., FerrettiG.Breast cancer metastatic to the choroid in a male patient: case report. Tumori2003; 89: 333–5.
37.
SinghM., KotagiriA.K., TeimoryM.Choroidal and optic disc metastases in a man with metachronous and metastatic breast carcinoma [comment]. Acta Ophthalmol Scand2007; 85: 688–9.
