Intraoperative Floppy Iris Syndrome Associated with Risperidone Intake

Abstract

Purpose

Intraoperative floppy iris syndrome (IFIS) has been strongly associated with intake of selective α₁ adrenergic blockers, particularly tamsulosin. Intraoperative floppy iris syndrome has also been linked to the use of other drugs with some a antagonist activity.

Methods

We identified patients on long-term treatment with the antipsychotic agent risperidone who showed typical features of IFIS during cataract surgery.

Results

We report 3 eyes in 2 patients taking risperidone in which typical features of IFIS were noted during cataract surgery.

Conclusions

Risperidone is a widely prescribed drug in psychiatric practice and has α-blocking actions as well as strong affinity for serotonin 2A receptors. Ophthalmologists should be aware of the possible association with IFIS when performing cataract surgery on patients taking risperidone.