Have We Found the Panacea to Covid-19 with Remdesivir,An Old but Newly Packaged Drug?

worldometers. COVID-19 Coronavirus Pandemic 2020, 14 May 2020. https://www.worldometers.info/coronavirus/ (accessed 12/05/20).

Dörnemann J , Burzio C , Ronsse A . First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease. Journal Infect Dis 2017; 215: 171–4.

Mulangu S , Dodd LE , Davey RT . A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics. New Engl J Med 2019; 381: 2293–303.

Sheahan TP , Sims AC , Graham RL . Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Sci Transl Med 2017; 9: eaal3653.

Wang M , Cao R , Zhang L . Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 2020; 30: 269–71.

de Wit E , Feldmann F , Cronin J . Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection. Proc Natl Acad Sci USA 2020; 117: 6771–6.

Meng L , Qiu H , Wan L . Intubation and Ventilation amid the COVID-19 Outbreak: Wuhan's Experience. Anesthesiology 2020; 132: 1317–32.

Richardson S , Hirsch JS , Narasimhan M . Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA 2020: e206775 [Epub ahead of print 22/04/20].

Grein J , Ohmagari N , Shin D . Compassionate Use of Remdesivir for Patients with Severe Covid-19. N Engl J Med 2020: NEJMoa2007016 [Epub ahead of print 10/04/20].

Manja V , Lakshminrusimha S . Epidemiology and Clinical Research Design, Part 1: Study Types. Neoreviews 2014; 15: e558-e69.

National Institutes of Health: NIH clinical trial shows remdesivir accelerates recovery from advanced COVID-19 [Press release]. 2020 April 29. https://www.nih.gov/news-events/news-releases/nih-clinical-trial-shows-remdesivir-accelerates-recovery-advanced-covid-19 (accessed 12/05/20).

Wang Y , Zhang D , Du G . Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet 2020. 2020 Apr 29 doi: 10.1016/ S0140-6736(20)31022-9.

U.S. national Library of Medicine. ClinicalTrials.gov. A trial of remdesivir in adults with severe COVID-19 2020, April 15. https://clinicaltrials.gov/ct2/show/study/NCT04257656 (accessed 12/5/20).