More people are using electronic cigarettes (e-cigarettes) and fewer people are smoking conventional tobacco cigarettes. A wide variety of e-cigarettes are available and there is emerging evidence that they may help with smoking cessation. This evidence-based clinical review summarises the latest evidence regarding use of e-cigarettes as smoking cessation aids. The ongoing debate surrounding the safety and regulation of e-cigarettes is also discussed.
BrittonJ. Death, disease, and tobacco. Lancet2017; 389: 1861–2.
2.
Ash. Use of E-Cigarettes Among Adults in Great BritainLondon: ASH; 2017.
3.
Royal College of Physicians. Nicotine Without Smoke: Tobacco Harm ReductionLondon: Royal College of Physicians; 2016.
4.
McNeillA, BroseLS, CalderR. Evidence Review of E-Cigarettes and Heated Tobacco Products 2018London: Public Health England;2018.
5.
GlantzSA, BarehamDW. E-cigarettes: use, effects on smoking, risks, and policy implications. Annu Rev Public Health2018; 39: 215–35.
6.
KosmiderL, SobczakA, FikM. Carbonyl compounds in electronic cigarette vapors: effects of nicotine solvent and battery output voltage. Nicotine Tob Res2014; 16: 1319–26.
7.
HuangJ, DuanZ, KwokJ. Vaping versus JUULing: how the extraordinary growth and marketing of JUUL transformed the US retail e-cigarette market. Tob Control2018.
National Institute of Health and Care Excellence. Stop smoking interventions and services. 2018. https://www.nice.org.uk/guidance/ng92 (accessed 10/08/2018).
19.
BeardE, WestR, MichieS. Association between electronic cigarette use and changes in quit attempts, success of quit attempts, use of smoking cessation pharmacotherapy, and use of stop smoking services in England: time series analysis of population trends. BMJ2016; 354: i4645.
20.
SimonaviciusE, McNeillA, ArnottD. What factors are associated with current smokers using or stopping e-cigarette use?Drug Alcohol Depend2017; 173: 139–43.
21.
BrownJ, BeardE, KotzD. Real-world effectiveness of e-cigarettes when used to aid smoking cessation: a cross-sectional population study. Addiction2014; 109: 1531–40.
22.
HajekP. Electronic cigarettes have a potential for huge public health benefit. BMC Med2014; 12:225.
23.
PisingerC. Why public health people are more worried than excited over e-cigarettes. BMC Med2014; 12:226.
24.
FairchildAL, BayerR, ColgroveJ. The renormalization of smoking? E-cigarettes and the tobacco ‘'endgame'’. N Engl J Med2014; 370: 293–5.
El DibR, SuzumuraEA, AklEA. Electronic nicotine delivery systems and/or electronic non-nicotine delivery systems for tobacco smoking cessation or reduction: a systematic review and meta-analysis. BMJ Open2017; 7: e012680.
27.
KhoudigianS, DevjiT, LytvynL. The efficacy and short-term effects of electronic cigarettes as a method for smoking cessation: a systematic review and a meta-analysis. Int J Public Health2016; 61: 257–67.
28.
BullenC, HoweC, LaugesenM. Electronic cigarettes for smoking cessation: a randomised controlled trial. Lancet2013; 382: 1629–37.
29.
CaponnettoP, CampagnaD, CibellaF. Efficiency and safety of an electronic cigarette (ECLAT) as tobacco cigarettes substitute: a prospective 12-month randomized control design study. PLoS One2013; 8: e66317.
30.
HalpernSD, HarhayMO, SaulsgiverK. A pragmatic trial of e-cigarettes, incentives, and drugs for smoking cessation. N Engl J Med2018; 378: 2302–10.
KalkhoranS, GlantzSA. E-cigarettes and smoking cessation in real-world and clinical settings: a systematic review and metaanalysis. Lancet Respir Med2016; 4: 116–28.
33.
NHS Health Scotland. Consensus Statement on E-Cigarettes. Edinburgh: NHS Health Scotland; 2017.
34.
National Academies of Sciences, Engineering, and Medicine. Public Health Consequences of E-Cigarette. Washington, DC: The National Academies Press; 2018.
35.
HackshawA, MorrisJK, BonifaceS. Low cigarette consumption and risk of coronary heart disease and stroke: meta-analysis of 141 cohort studies in 55 study reports. BMJ2018; 360: j5855.
36.
PopeCA, BurnettRT, KrewskiD. Cardiovascular mortality and exposure to airborne fine particulate matter and cigarette smoke: shape of the exposure-response relationship. Circulation2009; 120: 941–8.
37.
AlzahraniT, PenaI, TemesgenN. association between electronic cigarette use and myocardial infarction. Am J Prev Med2018; 55: 455–61.
38.
ScottA, LuggST, AldridgeK. Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages. Thorax2018; 73: 1161–9.
39.
FultonE, GokalK, GriffithsS. More than half of adolescent e-cigarette users had never smoked a cigarette: findings from a study of school children in the UK. Public Health2018; 161: 33–5.
40.
Ash. Use of E-Cigarettes Among Young People in Great BritainLondon: ASH; 2018.
41.
SonejiS, Barrington-TrimisJL, WillsTA. Association between initial use of e-cigarettes and subsequent cigarette smoking among adolescents and young adults: a systematic review and meta-analysis. JAMA Pediatr2017; 171: 788–97.
42.
KennedyRD, AwopegbaA, De LeonE. Global approaches to regulating electronic cigarettes. Tob Control2017; 26: 440–5.