Is It Time to Say Good Bye to Blow-By?

Everard ML , Clark AR , Milner AD . Drug delivery from holding chambers with attached facemask. Arch Dis Child, 1992; 67(5):580–585.

Everard ML , Clark AR , Milner AD . Drug delivery from jet nebulisers. Arch Dis Child, 1992; 67(5):586–591.

Rubin BK , Fink JB . Aerosol therapy for children. Respir Care Clin N Am, 2000; 7(2):175–213.

Salmon B , Wilson NM , Silverman M . How much aerosol reaches the lungs of wheezy infants and toddlers?. Arch Dis Child, 1990; 65(4):401–403.

Newhouse MT . Pulmonary drug targeting with aerosols: principles and clinical applications in adults and children. Am J Asthma Allergy Pediatr, 1993; 7(1):23–25.

Chua HL , Collis GG , Newbury AM , Chan K , Bower GD , Sly PD , LeSouef PN . The influence of age on aerosol deposition in children with cystic fibrosis. Eur Respir J, 1994; 7(12):2185–2291.

Newhouse MT , Dolovich M . Aerosol therapy in children. In: Chernick V , Mellins RB , editors. Basic mechanisms of pediatric respiratory disease: cellular and integrative. Philadelphia: Decker; 1991:409–417.

Fok TF , Monkman S , Dolovich M , Gray S , Coates G , Paes B . Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia. Pediatr Pulmonol, 1996; 21(5):301–309.

Anhoj J , Thorsson L , Bisgaard H . Lung deposition of inhaled drug increases with age. Am J Respir Crit Care Med, 2000; 162(5):1819–1822.

Amirav I , Newhouse MT . Aerosol therapy with valved holding chambers in young children: importance of the facemask seal. Pediatrics, 2001; 108(2):389–394.

Iles R , Lister P , Edmunds AT . Crying significantly reduces absorption of aerosolized drug in infants. Arch Dis Child, 1999; 81(2):163–165.

Lin HL , Restrepo RD , Gardenhire DS , Rau JL . Effect of face mask design on inhaled mass of nebulized albuterol, using a pediatric breathing model. Respir Care, 2007; 52(8):1021–1026.

Restrepo RD , Dickson SK , Rau JL , Gardenhire DS . An investigation of nebulized bronchodilator delivery using a pediatric lung model of spontaneous breathing. Respir Care, 2006; 51(1):56–61.

Rubin BK . Bye-bye, blow by. Respir Care, 2007; 52(8):981.

Sangwan S , Gurses BK , Smaldone GC . Facemasks and facial deposition of aerosols. Pediatr Pulmonol, 2004; 37(5):447–452.

Smaldone GC , Berg E , Nikander K . Variation in pediatric aerosol delivery: importance of facemask. J Aerosol Med, 2005; 18(3):354–363.

Mansour MM , Smaldone GC . Blow-by as potential therapy for uncooperative children: an in-vitro study. Respir Care, 2012; 57(12):2004–2011.