Can Albuterol Be Blamed for Lactic Acidosis?

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References

Vernon

, Letourneau

. Lactic acidosis: recognition, kinetics, and associated prognosis. Crit Care Clin, 2010; 26(2):255–283.

Mishra

, Radhi

, Nugent

. A 20-year-old woman with severe asthma refractory to primatene mist. Chest, 2010; 138(5):1253–1255.

Mountain

. Acid-base disturbances in acute asthma. Chest, 1990; 98(3):651–655.

Gevers

, Dowdle

. The effect of pH on glycolysis in vitro. Clin Sci, 1963; 25:343–349.

Relman

. Metabolic consequences of acid-base disorders. Kidney Int, 1972; 1(5):347–359.

Eldridge

, Salzer

. Effect of respiratory alkalosis on blood lactate and pyruvate in humans. J Appl Physiol, 1967; 22(3):461–468.

Freedman

, Cooke

, Moxham

. Production of lactic acid by respiratory muscles. Thorax, 1983; 38(1):50–54.

Liem

, Mnookin

, Mahla

. Albuterol-induced lactic acidosis. Anesthesiology, 2003; 99(2):505–506.

Manthous

. Lactic acidosis in status asthmaticus: three cases and review of the literature. Chest, 2001; 119(5):1599–1602.

10.

Braden

. Lactic acidosis associated with the therapy of acute bronchospasm. N Engl J Med, 1985; 313(14):890–891.

11.

Corbridge

, Hall

. The assessment and management of adults with status asthmaticus. Am J Respir Crit Care Med, 1995; 151(5):1296–1316.

12.

Haffner

, Kendall

. Metabolic effects of beta 2-agonists. J Clin Pharm Ther, 1992; 17(3):155–164.

13.

Kovacevic

, Schwahn

, Schuster

. Hyperlactic acidosis as metabolic side-effect of albuterol and theophylline in acute severe asthma. Klin Padiatr, 2010; 222(4):271–272.

14.

Richards

, Chang

, Stempel

. Hyperlactacidemia associated with acute ritodrine infusion. Am J Obstet Gynecol, 1983; 146(1):1–5.

15.

Cotton

. The effects of terbutaline on acid base, serum electrolytes, and glucose homeostasis during the management of preterm labor. Am J Obstet Gynecol, 1981; 141(6):617–624.

16.

Tobin

, Pellizzer

, Santamaria

. Mechanisms by which systemic salbutamol increases ventilation. Respirology, 2006; 11(2):182–187.

17.

Maury

. A paradoxical effect of bronchodilators. Chest, 1997; 111(6):1766–1767.

18.

Creagh-Brown

, Ball

. An under-recognized complication of treatment of acute severe asthma. Am J Emerg Med, 2008; 26(4):514.e1–e3.

19.

Tobin

. Intravenous salbutamol: too much of a good thing?. Crit Care Resusc, 2005; 7(2):119–127.

20.

Rabbat

. Hyperlactatemia during acute severe asthma. Intensive Care Med, 1998; 24(4):304–312.

21.

Rodrigo

, Rodrigo

. Elevated plasma lactate level associated with high dose inhaled albuterol therapy in acute severe asthma. Emerg Med J, 2005; 22(6):404–408.

22.

Stratakos

. Transient lactic acidosis as a side effect of inhaled salbutamol. Chest, 2002; 122(1):385–386.