Dexmedetomidine is a selective alpha-2 receptor agonist that possesses both sedative and analgesic properties, with minimal respiratory depression. We report the successful administration of dexmedetomidine on a 16-year-old primigravida woman that allowed the patient to tolerate application of bi-level positive airway pressure ventilation in treatment of acute hypoxemic respiratory failure.
McElhattonPR. The effects of benzodiazepine use during pregnancy and lactation. Reprod Toxicol, 1994; 8(6):461–475.
4.
ConstantinJM, SchneiderE, Cavot-ConstantinS, GuerinR, BannierF, FutierE, BazinJE. Remifentanil-based sedation to treat noninvasive ventilation failure: a preliminary study. Intensive Care Med, 2007; 33(1):82–87.
5.
LeeSK. Clinical use of dexmedetomidine in monitored anesthesia care. Korean J Anesthesiol, 2011; 61(6):451–452.
6.
Ala-KokkoTI, PienimäkiP, LampelaE, HollménAI, PelkonenO, VähäkangasK. Transfer of clonidine and dexmedetomidine across the isolated perfused placenta. Acta Anaesthesiol Scand, 1997; 41(2):313–319.
7.
TariqM, CernyV, ElfakiI, KhanHA. Effects of subchronic versus acute in utero exposure to dexmedetomidine on foetal developments in rats. Basic Clin Pharmacol Toxicol, 2008; 103(2):180–185.
8.
VasilevskisEE, MorandiA, BoehmL, PandharipandePP, GirardTD, JacksonJC, et al. Delirium and sedation recognition using validated instruments: reliability of bedside intensive care unit nursing assessments from 2007 to 2010. J Am Geriatr Soc, 2011; 59(Suppl 2):S249–S255.
9.
TakasakiY, KidoT, SembaK. Dexmedetomidine facilitates induction of noninvasive positive pressure ventilation for acute respiratory failure in patients with severe asthma. J Anesth, 2009; 23(1):147–50.
10.
AkadaS, TakedaS, YoshidaY, NakazatoK, MoriM, HongoT, et al. The efficacy of dexmedetomidine in patients with noninvasive ventilation: a preliminary study. Anesth Analg, 2008; 107(1):167–170.
11.
NeumannMM, DavioMB, MacknetMR, ApplegateRL2nd. Dexmedetomidine for awake fiberoptic intubation in a parturient with spinal muscular atrophy type III for cesarean delivery. Int J Obstet Anesth, 2009; 18(4):403–407.
12.
PalanisamyA, KlickovichRJ, RamsayM, OuyangDW, TsenLC. Intravenous dexmedetomidine as an adjunct for labor analgesia and cesarean delivery anesthesia in a parturient with a tethered spinal cord. Int J Obstet Anesth, 2009; 18(3):258–261.
13.
ToyamaH, WagatsumaT, EjimaY, MatsubaraM, KurosawaS. Cesarean section and primary pulmonary hypertension: the role of intravenous dexmedetomidine. Int J Obstet Anesth, 2009; 18(3):262–267.
14.
Abu-HalawehSA, Al OweidiAK, Abu-MaloohH, ZabalawiM, AlkazalehF, Abu-AliH, RamsayMA. Intravenous dexmedetomidine infusion for labour analgesia in patient with preeclampsia. Eur J Anaesthesiol, 2009; 26(1):86–87.