Successful Treatment of Rapidly Progressing Severe Fever with Thrombocytopenia Syndrome with Neurological Complications using Intravenous Immunoglobulin and Corticosteroid
Free accessCase reportFirst published online October, 2016
Successful Treatment of Rapidly Progressing Severe Fever with Thrombocytopenia Syndrome with Neurological Complications using Intravenous Immunoglobulin and Corticosteroid
Since the first report of severe fever with thrombocytopenia syndrome (SFTS) in China, diagnostic methods have evolved. Despite definitive diagnoses, SFTS management has focused on prevention and supportive care. Although conservative treatment is effective for mild cases, there is an urgent need for an effective therapeutic modality to treat severe cases because of the high mortality associated with these. In this study, we report two cases of SFTS with neurological manifestations that fully recovered after a combination treatment consisting of intravenous immunoglobulin and corticosteroid.
References
1.
XuB., LiuL., HuangX.Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus.PLoS Pathog2011; 7: e1002369.
2.
YuX.J., LiangM.F., ZhangS.Y.Fever with thrombocytopenia associated with a novel bunyavirus in China.N Engl J Med2011; 364: 1523–1532.
3.
DengB., ZhouB., ZhangS.Clinical features and factors associated with severity and fatality among patients with severe fever with thrombocytopenia syndrome Bunyavirus infection in Northeast China.PLoS ONE2013; 8: e80802.
4.
LiuW., LuQ.B., CuiN.Case-fatality ratio and effectiveness of ribavirin therapy among hospitalized patients in China who had severe fever with thrombocytopenia syndrome.Clin Infect Dis2013; 57: 1292–1299.
5.
OhW.S., HeoS.T., KimS.H.Plasma exchange and ribavirin for rapidly progressive severe fever with thrombocytopenia syndrome.Int J Infect Dis2014; 18: 84–86.
6.
LiuS., ChaiC., WangC.Systematic review of severe fever with thrombocytopenia syndrome: virology, epidemiology, and clinical characteristics.Rev Med Virol2014; 24: 90–102.
CuiN., LiuR., LuQ.B.Severe fever with thrombocytopenia syndrome bunyavirus-related human encephalitis.J Infect2015; 70: 52–59.
9.
GaiZ.T., ZhangY., LiangM.F.Clinical progress and risk factors for death in severe fever with thrombocytopenia syndrome patients.J Infect Dis2012; 206: 1095–1102.
10.
Tasdelen FisginN., ErgonulO., DoganciL., TulekN.The role of ribavirin in the therapy of Crimean-Congo hemorrhagic fever: early use is promising.Eur J Clin Microbiol Infect Dis2009; 28: 929–933.
11.
HugginsJ W.. Prospects for treatment of viral hemorrhagic fevers with ribavirin, a broad-spectrum antiviral drug.Rev Infect Dis1989; 11Suppl 4: S750–S761.
12.
LuQ.B., ZhangS.Y., CuiN.Common adverse events associated with ribavirin therapy for severe fever with thrombocytopenia syndrome.Antiviral Res2015; 119: 19–22.
13.
SunL., HuY., NiyonsabaA.Detection and evaluation of immunofunction of patients with severe fever with thrombocytopenia syndrome.Clin Exp Med2014; 14: 389–395.
14.
ZhangY.Z., HeY.W., DaiY.A.Hemorrhagic fever caused by a novel Bunyavirus in China: pathogenesis and correlates of fatal outcome.Clin Infect Dis2012; 54: 527–533.
15.
ErduranE., BahadirA., PalanciN., GedikY.The treatment of Crimean-Congo hemorrhagic fever with high-dose methylprednisolone, intravenous immunoglobulin, and fresh frozen plasma.J Pediatr Hematol Oncol2013; 35: e19–e24.
