To our knowledge, there are no previously published cases of enteroviral infection complicated by pityriasis lichenoides et varioliformis acuta (PLEVA). A 30-year-old woman is reported with a severe form of PLEVA, preceded by hand, foot and mouth disease. Immunosuppressive treatment with cyclosporin A resulted in rapid clinical improvement.
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LawenA.Biosynthesis of cyclosporins and other natural peptidyl prolyl cis/trans isomerase inhibitors.Biochim Biophys Acta2015; 1850: 2111–2120.
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UzomaM.A., WilkersonM.G., CarrV.L., WesthovenG.S., RaimerS.A.Pentoxifylline and cyclosporine in the treatment of febrile ulceronecrotic Mucha-Habermann disease.Pediatr Dermatol2014; 31: 525–527.
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LipskerD., SauratJ.H.A new concept: paraviral eruptions.Dermatology2005; 211: 309–311.
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MardivirinL., Valeyrie-AllanoreL., Branlant-RedonE.Amoxicillin-induced fare in patients with DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms): report of seven cases and demonstration of a direct effect of amoxicillin on human herpesvirus 6 replication in vitro.Eur J Dermatol2010; 20: 68–73.
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Zetina-TunH., de la Cerda-BelmontG.A., Lezama-UrtechoC.A., Careaga-ReynaG.Mucha-Habermann disease and orthotopic heart transplant. Case report.Rev Med Inst Mex Seguro Soc2013; 51: 456–458.
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YangE.V., Webster MarketonJ., ChenM., LoK.W., KimS.J., GlaserR.Glucocorticoids activate Epstein Barr virus lytic replication through the upregulation of immediate early BZLF1 gene expression.Brain Behav Immun2010; 24: 1089–1096.