We report the case of a Gabonese HIV-patient who presented with haemoptysis, weight loss, fulminant diarrhoea and subsequent ileus and elevated CD4+ T-cell counts. He was diagnosed with Strongyloides stercoralis and human T-lymphotrophic virus type-1 infection. After treatment of the strongyloides hyperinfection syndrome, his CD4+ T-cell counts dropped greatly. The initially elevated CD4+ T-cell counts were misleading to the clinicians with regard to decision-making on antiretroviral therapy initiation.
References
1.
MejiaR., NutmanT.B.Screening, prevention, and treatment for hyperinfection syndrome and disseminated infections caused by Strongyloides stercoralis.Curr Opin Infect Dis2012; 25: 458–463.
2.
FardetL., GenereauT., PoirotJ.L., GuidetB., KettanehA., CabaneJ.Severe strongyloidiasis in corticosteroid-treated patients: case series and literature review. J Infect2007; 54: 18–27.
3.
SiegelM.O., SimonG.L.Is human immunodeficiency virus infection a risk factor for Strongyloides stercoralis hyperinfection and dissemination. PLoS Negl Trop Dis20126: e1581.
4.
SindhuS., TomaE., CordeiroP., AhmadR., MorissetR., MenezesJ.Relationship of in vivo and ex vivo levels of TH1 and TH2 cytokines with viremia in HAART patients with and without opportunistic infections. J Med Virol2006; 78: 431–439.
5.
CarvalhoE.M., Da FonsecaP.A.Epidemiological and clinical interaction between HTLV-1 and Strongyloides stercoralis. Parasite Immunol2004; 26: 487–497.
6.
PortoA.F., NevaF.A., BittencourtH.HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis. Parasite Immunol2001; 23: 503–507.
7.
MontesM., SanchezC., VerdonckK.Regulatory T cell expansion in HTLV-1 and Stronyloidiasis co-infection is associated with reduced IL-5 responses to Strongyloides stercoralis antigen. PLoS Negl Trop Dis2009; 3: e456.
8.
JonesK.S., Petrow-SadowskiC., HuangY.K., BertoletteD.C., RuscettiF W.Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4+ T cells. Nat Med2008; 14: 429–436.