Selection of An M184V Mutation in the Cerebrospinal Fluid of a Treatment-Naive HIV-Infected Individual Starting Darunavir-Based Therapy

Abstract

Here, we describe a newly diagnosed HIV-1-infected patient, in whom shortly after the initiation of a darunavir- based regimen, the HIV-1 virus exclusively mutated in the cerebrospinal fluid (CSF), leading to an increase in CSF HIV-1 RNA load and neurological complaints.