Here, we report a case of chronic granulomatous tubulo-interstitial nephritis related to atazanavir crystals in a HIV type-1-infected patient. Renal function in this patient was partially recovered after atazanavir withdrawal and steroid therapy. Many reports have described atazanavir-associated urolithiasis, but this is the first case that describes chronic granulomatous nephropathy.
References
1.
ChangH.R., PellaP.M.Atazanavir urolithiasis. N Engl J Med2006; 355: 2158–2159.
2.
CouzigouC., DaudonM., MeynardJ.L.Urolithiasis in HIV-positive patients treated with atazanavir. Clin Infect Dis2007; 45: e105–e108.
3.
Chan-TackK.M., TruffaM.M., StrubleK.A., BirnkrantD.B.Atazanavir associated nephrolithiasis: cases from the US Food and Drug Administration's Adverse Event Reporting System. AIDS2007; 21: 1215–1218.
4.
BrewsterU.C., PerazellaM.A.Acute interstitial nephritis associated with atazanavir, a new protease inhibitor. Am J Kidney Dis2004; 44: e81–e84.
5.
IzzedineH.M'rad MB, Bardier A, Daudon M, Salmon D. Atazanavir crystal nephropathy. AIDS2007; 21: 2357–2358.
6.
KirkO., MocroftA., ReissP.Chronic kidney disease and exposure to ART in a large cohort with long-term follow-up: the EuroSIDA study.17th Conference on Retroviruses and Opportunistic Infections. 16–19 February 2010, San Francisco, CA, USA. Abstract 107LB.
7.
SchmidS., OpravilM., ModdelM.Acute interstitial nephritis of HIV-positive patients under atazanavir and tenofovir therapy in a retrospective analysis of kidney biopsies. Virchows Arch2007; 450: 665–670.
