Abstract
The immediate early gene, c-fos encodes a nuclear phos-phoprotein, Fos which has been proposed to be a third messenger to regulate the expression of specific target genes. The present work demonstrated the coexistence of Fos protein and proopiomelanocortin (POMC) mRNA in the hypothalamic arcuate nucleus (Arc) using techniques of in situ hybridization and inununocytochemistry. The results suggest the activation of β-endorphinergic (β-EP) neurons in the Arc by eletroacupuncture (EA) and the possible involvement of Fos in modulating POMC expression.
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