Sage Journals: Discover world-class research

Abstract

The influence of orphanin FQ (OFQ) (a newly discovered 17-amino acid peptide) on acupuncture analgesia (AA) was assessed in rat tail-flick model. Intraccrebroventricular (icv) injection of OFQ(l μg) elicited a significant decrement of pain threshold which was abolished by the repeated pretrcatmenl with anliscnse oligonucleotide (ASO) to OFQ receptor. Eleclroacupuncturc (EA) induced an obvious analgesic effect; when OFQ was used combined with EA, it showed a dose-dependent effect on antagonizing the EA analgesia. When rat was repeatedly icv injected with ASO to block the synthesis of OFQ receptor, the EA analgesia was enhanced markedly. In this instance, the OFQ did not show antagonistic effect on EA analgesia any more. The results suggest that the OFQ play its antagonistic role on EA analgesia via activating OFQ receptor.

Keywords

Acupuncture Angina pectoris Lifestyle Shiatsu

Get full access to this article

View all access options for this article.

References

Involvement of endogenous opioid peptides in acupuncture analgesia. Pain, 31,99–121, 1987.

Zhu

C.B.

Jin

and Xu

S.F.

Accelerated release of enkephalin and g -endorphin in rat brain by droperidol during electroacupuncture analgesia. Chin, J. Physiol. Sci., 11,123–128, 1995.

Zhang

A.Z.

Huang

D.K.

Zeng

D.Y.

Zhang

L.M.

and Wang

D.L.

The changes of endorphins in perfusate of certain brain nuclei in rabbits during acupuncture analgesia. Acta Physiol Sin., 33,8–16,1981.

S.F.

Cao

X.D.

W.Y.

Z.B.

and Pan

Y.Y.

Effect of combination of drugs with acupuncture on analgesic efficacy. Acupuncture & Electrotherapeutics Res., Int. J., 221,103–113,1989.

Zhou

Y.Q.

and Xu

S.F.

Effect of opiate agonists on acupuncture analgesia. Acia Acad. Med- Primae Shanghai. 12,219–222,1985.

Han

J.S.

The role of CCK in electroacupuncture analgesia and electroacupuncture tolerance. In: Dourish C.T., et al. eds. Multiple CCK receptors in CNS. New York: Oxford Univ. Press, 480–502,1992.

Wang

K.W.

and Han

J.S.

Evidences of angiotensin II Involved in the electroacupuncturc tolerance. Chin. J. Prac, Physiol., 5, 32–36,1989.

Mollereau

Parmentier

Mailleux

Butour

J.L.

Moisand

Chalon

Caput

Vassart

, and Meunier

J.C.

a novel member of the opioid receptor family cloning, functional expression and localization. FEBS Lett., 341,33–38, 1994.

Bunzow

J.R.

Saez

Mortrud

Bouvier

Williams

J.T.

Low

and Grandy

D.K.

Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type. FEBS Lett., 347,284–288, 1994.

10.

Fukude

Kato

Mori

Nishi

Takeshima

Iwabe

Miyata

Houtani

and Sugimoto

cDAN cloning and regional distribution of a novel member of the opioid receptor family. FEBS Lett. 342,42–46, 1994.

11.

Wang

J.B.

Johnson

P.S.

Imai

, Persico

A.M.

, Ozenberger

B.A.

, Eppler

C.M.

and Uhl

G.R.

, cDNA cloning of an orphan opiate receptor gene family member and its splice variant. FEBS Lett., 348.75-79, 1994.

12.

Reinscheid

k., Nothacker

H.P.

, Bourson

, Ardati

, Henningsen R.A., Bunzow, JR., Grandy

D.K.

, Langen, IL, Monsma

F.J.

, and Civelli, 0., Orphanin

: A neuropeptide that activates an opioid like G-protein-coupled receptor. Science. 270, 792–794.1995.

13.

Meunier

J.C.

Mollereau

Toll

Suaudeau

Molsand

Alvincrle

Butour

J.L.

Guilemot

J.C.

Ferrara

Monsarrat

Mazargull

Vassart

Parmentler

, and Costentln

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature. 377. 532–535, 1995.

14.

Yang

H.L.

Luo

R.S.

Wang

L.X.

Zhu

D.X.

Chi

C.W.

Primary structure and disulfide bridge location of arrowhead double-headed proteinase inhibitors. J Biochem., 111,537–545, 1992.

15.

W.F.

Tao

W.K.

Gong

Z.Z.

and Chi

C.W.

cDNA and genomic structures of arrowhead proteinase inhibitors., J Biochem., 113,153–158, 1993.

16.

Zimmermann

Ethical guidelines for investigations of experimental pan in conscious animals. Pain. 16,109–110, 1983.

17.

Zhu

C.B.

Liu

Y. H.

and Xu

S.F.

Increase in opioid receptor binding sites in rat brain during acupuncture analgesia enhanced by droperidol: an autoradiographic study. Chin. J. Neurosci. 2, 7–13, 1995.

Antagonistic Action of Orphanin FQ on Acupuncture Analgesia in Rat Brain

Abstract

Keywords

Get full access to this article

References