Patho-Physiology of Acupuncture Effects,Acth and Morphine-Like Substances,Pain,Phantom Sensations (Phantom Pain,Itch and Coldness),Brain Micro-Circulation,and Memory

Abstract

Acupuncture is being gradually integrated by many physicians into their daily practice of medicine in the U.S. but claims are still being made by influential scientists, physicians and academicians that acupuncture has no scientific basis or is only a form of hypnosis without adequately studying the phenomenon before making their statements. A narrow approach to acupuncture research limits itself to study of the nervous system, although there are equally important effects and subsequent implications in the circulatory and endocrine systems. The author has found that acupuncture effects on the micro-circulatory system can normally be classified into 3 consecutively changing phases: vaso-constriction, quasi-control, & vaso-dilation of mainly capillaries and arterioles. Vaso-dilation effects are often accompanied by other significant blood chemistry and CBC changes, most of which resemble ACTH administration-like effects. Such changes as generalized vaso-dilation effects, particularly vaso-dilation effects of brain micro-circulatory networks, can give various degrees of improvement in such areas as insomnia, irritability, impaired learning, memory, and brain circulation. Pain threshold to electrical stimulation is often enhanced by acupuncture in the acupunctured area, without respiratory depressant effect characteristics of opiates. The “Gate Control Theory” of Melzack & Wall made a great contribution in the study of pain, and its many difficulties and contradictions are discussed. Also discussed is the subject of pain, phantom pain & itch, memory, and their relation to the “Gate Control theory.” The question is raised why some people develop phantom pain or itch and others do not. The author has proposed a concept of “coded stored memory molecules” for chronic pain and phantom sensation, using examples of “phantom pain,” “phantom itch,” and “phantom coldness.” The inter-relationship of the effects of morphine derivatives & their analogues & antagonists and acupuncture is discussed, along with release of an endogenous morphine-like substance and an ACTH-like substance with opiate-like characteristics.

Keywords

Acupuncture micro-circulatory system blood chemistry CBC vaso-constriction vaso-dilation brain micro-circulation insomnia irritability learning memory “gate control theory”phantom pain & itch “coded stored memory molecules”morphine derivatives and antagonists naloxone morphine-like substance methodone prostaglandins Système micro-circulatoire Chimie sanguine Vaso-constriction Vaso-dilatation micro-circulation du cerveau Insomnie Irritabilité Facultés intellectuelles Mémoire Théorie de “Gate Control”Fantôme de la douleur de la démangeaison & de la froidure “Molécules de mémoire amassées et codifiées”Dérivatifs et antagonistes de la morphine Naloxone Substances semblables à la morphine Méthadone Prostaglandins Akupunktur Mikrozirkulation Blutchemie Blutbild (CBC)Gefäßverengung Gefäßerweiterung Mikrozirkulation des Gehirns Schlaflosigkeit Aufregung Lernfähigkeit Gedächtnis “Torkontrolltheorie”Phantomschmerz -juckreiz und -kältegefühl Morphiumderivate und -antagonisten Morphiumähnliche Substanzen Methadone Prostaglandine

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References

Omura and Lee

, Applications of ultra-miniature photoelectric Plethysmographic sensors with a very short response time to the non-traumatic study of the circulatory system, presented at the annual meeting of the American Society for Artificial Internal Organs on April 20, 1971, at Palmer House, Chicago, and published in Trans. Am. Soc. Artif. Internal Organs, 17,392–404,1971.

Omura , The effects of acupuncture on the cardio-vascular system: studies on essential hypertension and blood chemistry, in Abstracts of the Third World Congress of Acupuncture, pp. 208–209, Seoul, South Korea, September 25–27,1973.

Omura , The effects of acupuncture on the nervous system: studies on threshold stimulation and conduction velocities of motor and sensory nerve fibers, in Abstracts of the Third World Congress of Acupuncture, pp. 209–210, Seoul, South Korea, September 25–27,1973.

Peng

A.T.C.

, Omura

, Cheng

H.C.

, Blancato

L.S.

, Acupuncture for relief of chronic pain and surgical analgesia, Am. Surgeon, 40,50–53,1974.

Omura , The relationship between the transmembrane action potential and the voitage-time-dependent, negative resistant characteristics of the voltage-current curves of excitable pacemaker and non-pacemaker cell membrane, presented at the New York Academy of Sciences, as guest speaker of Biophysics Division, onMay23, 1968, and published in the Trans. N.Y. Acad. Sci., Series II, 33,467–504, & Appendix i-xiv, 1971.

Omura , Cardio-vascular responses to acupuncture, abstract of a one-hour talk given as a guest speaker of the Symposium, in Proc. First World Symp. Acupuncture and Chinese Medicine, San Francisco, September 1973; also in the Am. J. Chinese Med., 2,112–113,1974.

Omura , The effects of acupuncture on circulatory system (especially on high blood pressure and triglyceride lowering effects) and a concept of ‘vaso-neuro-muscular functional unit system’, in the Abstracts of the Sixth Int. Cong, of Pharmacology, Helsinki, Finland, July 20–25,1975.

Omura , Patho-physiology of acupuncture treatment: effects of acupuncture on cardiovascular and nervous systems. Acupuncture & Electro-therapeut. Res. The International Journal. 1,51–142,1975.

Omura , Editorial: Some historical aspects of acupuncture and important problems to be considered in acupuncture and electro-therapeutic research, Acupuncture & Electro-Therapeut. Res, Int. J., 1,3–44,1975.

10.

Omura , Electro-acupuncture; its electro-physiological basis and criteria for effectiveness and safety-part I, Acupuncture & Electro-therapeut. Res. Int. J., 1,157–182,1975.

11.

Omura , Electro-acupuncture for drug addiction withdrawal syndrome, particularly methadone & individualized acupuncture treatment for the withdrawal syndromes of drug addictions and compulsive habits of excessive eating, drinking alcohol and smoking. Acupuncture & Electro-therapeut. Res., Int. J., 1,231–233,1975.

12.

Melzack and Wall

P.D.

, pain mechanisms: a new theory, Science, N. Y. 150, 971–979.

13.

Melzack , The Puzzle of Pain, Basic Books, New York, 1973.

14.

Wall

P.D.

and J. Cronly-Dillon, Pain, Itch and Vibration, Arch. Neurol, 2,365–375,1960.

15.

Wall

P.D.

and Sweet

W.H.

, Temporary, abolition of pain in man, Sciewce, N.Y. 155,108–109,1967.

16.

Shealy

C.N.

, Taslitz

, Mortimer

J.T.

, Becker

D.P.

, Electrical inhibition of pain; experimental evaluation, Anesthes. Analg. Curr. Res., 46,299–305,1967.

17.

Wageneder

F.W.

, St. Schuy, (Eds.), Electrotherapeutic Sleep and Electro-anesthesia, Vol. II, Excerpta Medica, Amsterdam, 1970.

18.

Manaka , Theories and Ways of Thinking in Acupuncture-Moxibustion (book written in Japanese), Sou-Gen-Sha, Osaka, Japan, 1971.

19.

Presman

A.S.

, Electromagnetic Fields and Life (translation editor: Frank

Brown A

, Jr., translated from Russian by F.L. Sinclair), Plenum Press, New York & London, 1970.

20.

Casey

K.L.

, The neurophysiologic basis of pain. Postgrad. Med. 53,58–63,1973.

21.

Pearson

A.A.

, Role of Gelatinous substance of spinal cord in conduction of pain. Arch. Neurol. Psychiat. 68,515–529,1952.

22.

Mayer

D.J.

, Pain inhibition by electrical brain stimulation: comparison to morphine. Neurosciences Res. Prog. Bull, 13, 94–100, 1975.

23.

de Wied, Ohus

, Gispen

W.H.

, I. Urban and Tj.B. van Wimersma Greidanus, Pituitary peptides on motivational, learning and memory processes, Proc. 6th Int. Cong. Pharmacology, Helsinki, Finland, July 20–25, 1975. Pergamon Press, Oxford, 1976.

24.

Cutting

W.C.

, Handbook of Pharmacology: The Actions and Uses of Drugs, 5th edn., Appletcn-Century Crofts, New York, 1972.

25.

Goodman

L.S.

and Oilman

, eds. The Pharmacological Basis of Therapeutics, Macmillan, 5th ed., 1975.

26.

Hubbard

J.I.

, The Biological Basis of Mental Activity, Addison-Wesley, Reading, Mass. 1975.

27.

Ramwell

P.W.

, (Ed.) The Prostaglandins, Vols. I & II, Plenum Press, New York, 1974.

28.

E.W. Horton, Prostaglandins: Monographs on Endocrinology, Vol. 7, Springer-Verlag, Berlin, 1972.

29.

Gordon

B.L.

II, Essentials of Immunology, 2nd edn., F.A. DAvis, 1974.

30.

Goldstein eds. The Opiate Narcotics: Neurochemical Mechanisms in Analgesia and Dependence, Proceedings of the International Narcotic Research Club Conference, May 21–24, 1975, Airlie House, Va., Pergamon Press, New York, 1975.

31.

Omura , Clinical applications and limitations of acupuncture (with special emphasis on the management of pain) and its pathophysiological basis, as a chapter in the new edition of the book. Management of pain, (edited by John Bonica), Lea & Febiger, Philadelphia (in press).

32.

Omura , Acupuncture Medicine, Vols. I, II & III, Basic Principles, Clinical Applications and Limitations of Manual and Electrical Acupuncture, Japan Publications Trading Co., Inc., San Francisco, New York, U.S.A. and Tokyo, Japan (in press).

33.

Omura , Patho-Physiology of the acupuncture treatment: the effects of acupuncture on the cardiovascular and nervous systems. Chapter 6, pp.87–121 in the book. Handbook of Medical Acupuncture, edited by Warren

, Van Nostrand-Reinhold, New York, 1976.

34.

Brodie

B.B.

and Bressler

, (Eds.), Minireviews of the Neuroseiences, from Life Sciences, Vols. 13 14, Pergamon Press, 1975.

35.

Omura , Smith

, Wong

, Appfel

, Taft

, Ν. Mintz, Mehter

, Lefkowitz

, Murphy

, et. al. Improved acupuncture treatment for withdrawal syndrome of drug addiction and compulsive habits of drinking alcohol and smoking. Am. J. Chinese Med. III, Supplement No. 1, 43–44,1975. Abstract of paper presented during the Third World Symp. on Acupuncture and Chinese Medicine, held in New York, March 21-26, 1975.

36.

Reynolds

D.V.

, Surgery in rat during electrical analgesia induced by focal brain stimulation. Science, N.Y., 164,444–445, 1968

37.

Mayer

D.J.

, Wolfle

T.L.

, H, Akill, B. Carder and Liebeskind

J.C.

, Analgesia from electrical stimulation in the brainstem of the rat. Science, N. Y., 174,1351–1354,1971.

38.

Bonica

J.J.

, Some recent advances in pain research and therapy. Acupuncture & Electro-Therapeutics Res., Int. J., 2,1976.

39.

Omura , Critical evaluation of the methods of measurement of ‘tingling threshold,’ ‘pain threshold,’ and ‘pain tolerance’ by electrical stimulation. Acupuncture & Electro-Therapeutics Res., Int. J., 2, 1976.

40.

Clark

W.C.

and Yang

J.C.

, Experimental pain following analgesic, placebo and acupuncture: an introduction to signal detection theory. Acupunctured Electro-Therapeutics Res., Int. J., 2,1976.