Hepatocyte Isolation and Transplantation in the Pig

Chen S. C. ; Hewitt W. R. ; Watanabe F. D. ; Eguchi S. ; Kahaku E. ; Middleton Y. ; Rozga J. ; Demetriou A. A. Clinical experience with a porcine hepatocyte-based liver support system. Int. J. Artif. Organs 19: 664–669; 1996.

Fox I. J. ; Chowdhury J. R. ; Kaufman S. S. ; Goertzen T. C. ; Chowdhury N. R. ; Warkentin P. I. ; Dorko K. ; Sauter B. V. ; Strom S. C. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N. Engl. J. Med. 338: 1422–1426; 1998.

Grompe M. Therapeutic liver repopulation for the treatment of metabolic liver diseases. Hum. Cell 12: 171–180; 1999.

Grossman M. ; Rader D. J. ; Muller D. W. ; Kolansky D. M. ; Kozarsky K. ; Clark B. J. 3rd ; Stein E. A. ; Lupien P. J. ; Brewer H. B. Jr. ; Raper S. E. A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia. Nat. Med. 1: 1148–1154; 1995.

Harrison S. J. ; Guidolin A. ; Faast R. ; Crocker L. A. ; Giannakis C. ; D'Apice A. J. ; Nottle M. B. ; Lyons I. Efficient generation of alpha (1, 3) galactosyltransferase knockout porcine fetal fibroblasts for nuclear transfer. Transgenic Res. 11: 143–150; 2002.

Ho D. W. ; Fan S. T. ; To J. ; Woo Y. H. ; Zhang Z. ; Lau C. ; Wong J. Selective plasma filtration for treatment of fulminant hepatic failure induced by D-galactosamine in a pig model. Gut 50: 869–876; 2002.

Kalpana K. ; Ong H. S. ; Soo K. C. ; Tan S. Y. ; Prema Raj J. An improved model of galactosamine-induced fulminant hepatic failure in the pig. J. Surg. Res. 82: 121–130; 1999.

Kobayashi N. ; Fujiwara T. ; Westerman K. A. ; Inoue Y. ; Sakaguchi M. ; Noguchi H. ; Miyazaki M. ; Cai J. ; Tanaka N. ; Fox I. J. ; Leboulch P. Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes. Science 287: 1258–1262; 2000.

Martin U. ; Kiessig V. ; Blusch J. H. ; Haverich A. ; von der Helm K. ; Herden T. ; Steinhoff G. Expression of pig endogenous retrovirus by primary porcine endothelial cells and infection of human cells. Lancet 352: 692–694; 1998.

Paradis K. ; Langford G. ; Long Z. ; Heneine W. ; Sandstrom P. ; Switzer W. M. ; Chapman L. E. ; Lockey C. ; Onions D. ; Otto E. Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. The XEN 111 Study Group. Science 285: 1236–1241; 1999.

Patience C. ; Takeuchi Y. ; Weiss R. A. Infection of human cells by an endogenous retrovirus of pigs. Nat. Med. 3: 282–286; 1997.

Rambhatla L. ; Chiu C-P. ; Kundu P. ; Peng Y. ; Carpenter M. K. Generation of hepatocyte-like cells from human embryonic stem cells. Cell Transplant. 12: 1–11; 2003.

Schwartz R. E. ; Reyes M. ; Koodie L. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J. Clin. Invest. 109: 1291–1302; 2002.

Suzuki A. ; Zheng Y-W. ; Kondo R. Flow-cytometric separation and enrichment of hepatic progenitor cells in the developing mouse liver. Hepatology 32: 1230–1239; 2002.

Thomson J. A. ; Itukovitz-Eldor J. ; Shapiro S. S. Embryonic stem cell lines derived from human blastocysts. Science 282: 1145–1147; 1998.

Watanabe F. D. ; Mullon C. J. P. ; Hewitt W. R. ; Arkadopoulos N. ; Kahaku E. ; Eguchi S. ; Khalili T. ; Arnaout W. ; Shackleton C. R. ; Rozga J. ; Solomon B. ; Demetriou A. A. Clinical experience with a bioartificial liver in the treatment of severe liver failure. A phase I clinical trial. Ann. Surg. 225: 484–493; 1997.

Wilson C. A. ; Wong S. ; Muller J. ; Davidson C. E. ; Rose T. M. ; Burd P. Type C retrovirus released from porcine primary peripheral blood mononuclear cells infects human cells. J. Virol. 72: 3082–3087; 1998.

Zhou X-D. ; Tokiwa T. ; Kano J. ; Kodama M. Isolation and primary culture of adult pig hepatocytes. Methods Cell Sci. 19: 277–284; 1998.